Q9D385 · AR2BP_MOUSE

  • Protein
    ADP-ribosylation factor-like protein 2-binding protein
  • Gene
    Arl2bp
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmidbody
Cellular Componentmitochondrial intermembrane space
Cellular Componentnucleoplasm
Molecular FunctionGTPase regulator activity
Molecular Functiontranscription coactivator activity
Biological Processmaintenance of protein location in nucleus
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein

Enzyme and pathway databases

    • R-MMU-83936Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Names & Taxonomy

Protein names

  • Recommended name
    ADP-ribosylation factor-like protein 2-binding protein
  • Short names
    ARF-like 2-binding protein
  • Alternative names
    • Binder of ARF2 protein 1

Gene names

    • Name
      Arl2bp
    • Synonyms
      Bart, Bart1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D385
  • Secondary accessions
    • Q9CQW6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity).
The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002871151-163ADP-ribosylation factor-like protein 2-binding protein

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed, with most abundant activity in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, retina, spleen, muscle and heart (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with ARL2 may be required for targeting to cilia basal body (By similarity).
Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6 (By similarity).
Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the ARL2BP family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9D385-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    163
  • Mass (Da)
    18,754
  • Last updated
    2001-06-01 v1
  • Checksum
    AE489178C0382255
MDALEEESFALSFSSASDAEFDAVVGCLEDIIMDDEFQLLQRNFMDKYYQEFEDTEENKLTYTPIFNEYISLVEKYIEEQLLERIPGFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSTPASQNNLRH

Q9D385-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1D5RMA5A0A1D5RMA5_MOUSEArl2bp91

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0253201-11in isoform 2
Alternative sequenceVSP_02531912-13in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK006418
EMBL· GenBank· DDBJ
BAB24578.1
EMBL· GenBank· DDBJ
mRNA
AK006646
EMBL· GenBank· DDBJ
BAB24686.1
EMBL· GenBank· DDBJ
mRNA
AK018229
EMBL· GenBank· DDBJ
BAB31126.1
EMBL· GenBank· DDBJ
mRNA
AK155242
EMBL· GenBank· DDBJ
BAE33143.1
EMBL· GenBank· DDBJ
mRNA
AK161325
EMBL· GenBank· DDBJ
BAE36323.1
EMBL· GenBank· DDBJ
mRNA
CT010168
EMBL· GenBank· DDBJ
CAJ18376.1
EMBL· GenBank· DDBJ
mRNA
BC002131
EMBL· GenBank· DDBJ
AAH02131.1
EMBL· GenBank· DDBJ
mRNA
BC024708
EMBL· GenBank· DDBJ
AAH24708.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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