Q9D2N4 · DTNA_MOUSE
- ProteinDystrobrevin alpha
- GeneDtna
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids746 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in synapse maturation and required for normal muscle function.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 243 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 246 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 258 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 261 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 267 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 270 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 280 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 284 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cell projection | |
Cellular Component | cytoplasm | |
Cellular Component | dystrobrevin complex | |
Cellular Component | extrinsic component of cytoplasmic side of plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | protein-containing complex | |
Cellular Component | sarcolemma | |
Cellular Component | synapse | |
Molecular Function | PDZ domain binding | |
Molecular Function | phosphatase binding | |
Molecular Function | zinc ion binding | |
Biological Process | synaptic signaling |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDystrobrevin alpha
- Short namesDTN-A
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9D2N4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000080037 | 1-746 | Dystrobrevin alpha | |||
Sequence: MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVARLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKMLARAAPAFLKGRGIQYSLNVADRLADEHVLIGLYVNMLRNDPPCMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDISFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQGTQGASSPRSSPSHTISRPIPMPIRSASACPTPTHTPQDSLTGVGGDVQEAFAQSSRRNLRSDLLVAADSITNTMSSLVKELNSEVASETESTVDSEFSRPQFEDLAPSPTSEKAFLAQIHSRKPGYIHGGAASTTHGDMVPEDGDPYTQPEDGNYENESVRQLENELQLEEYLKQKLQDEAYQVSLQG | ||||||
Modified residue | 666 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation of isoform 2 on tyrosine kinase substrate domain present in the C-terminus.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.
Developmental stage
Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later.
Gene expression databases
Interaction
Subunit
Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1. Interacts with MAGEE1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9D2N4 | Dtnbp1 Q91WZ8 | 3 | EBI-296019, EBI-643186 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, zinc finger, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-288 | Interaction with MAGEE1 | ||||
Sequence: MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVARLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKE | ||||||
Zinc finger | 238-294 | ZZ-type | ||||
Sequence: FHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKS | ||||||
Region | 397-447 | Syntrophin-binding region | ||||
Sequence: DRLADEHVLIGLYVNMLRNDPPCMLESSNRLDEEHRLIARYAARLAAESSS | ||||||
Coiled coil | 458-557 | |||||
Sequence: DISFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQ | ||||||
Region | 555-577 | Disordered | ||||
Sequence: LKQGTQGASSPRSSPSHTISRPI | ||||||
Compositional bias | 557-574 | Polar residues | ||||
Sequence: QGTQGASSPRSSPSHTIS | ||||||
Region | 646-667 | Disordered | ||||
Sequence: ETESTVDSEFSRPQFEDLAPSP | ||||||
Region | 684-721 | Disordered | ||||
Sequence: YIHGGAASTTHGDMVPEDGDPYTQPEDGNYENESVRQL |
Domain
The coiled coil domain mediates the interaction with dystrophin and utrophin.
Sequence similarities
Belongs to the dystrophin family. Dystrobrevin subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 7 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
Q9D2N4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length746
- Mass (Da)84,067
- Last updated2011-02-08 v2
- Checksum6AB7EF3B69250A09
Q9D2N4-2
- Name2
- SynonymsAlpha-dystrobrevin-1, Alpha-DB1
Q9D2N4-3
- Name3
- SynonymsAlpha-dystrobrevin-2B, Alpha-DB2B
Q9D2N4-4
- Name4
- SynonymsAlpha-dystrobrevin-2A, Alpha-DB2A
Q9D2N4-5
- Name5
- SynonymsAlpha-dystrobrevin-3, Alpha-DB3
Q9D2N4-6
- Name6
- SynonymsAlpha-dystrobrevin-3, Alpha-DB3
Q9D2N4-7
- Name7
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1Y7VLZ6 | A0A1Y7VLZ6_MOUSE | Dtna | 73 | ||
A0A1Y7VL34 | A0A1Y7VL34_MOUSE | Dtna | 746 | ||
A0A1Y7VJN9 | A0A1Y7VJN9_MOUSE | Dtna | 567 | ||
A0A1Y7VK79 | A0A1Y7VK79_MOUSE | Dtna | 35 | ||
Q8CFR5 | Q8CFR5_MOUSE | Dtna | 682 |
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 241 | in Ref. 1; CAA64519 | ||||
Sequence: V → L | ||||||
Sequence conflict | 251 | in Ref. 5; BAB31746 | ||||
Sequence: M → I | ||||||
Sequence conflict | 259 | in Ref. 4; AAD33915 | ||||
Sequence: Q → P | ||||||
Alternative sequence | VSP_004214 | 334 | in isoform 5 and isoform 7 | |||
Sequence: V → VDTW | ||||||
Alternative sequence | VSP_004215 | 363-419 | in isoform 2 and isoform 7 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_004216 | 364-371 | in isoform 5 and isoform 6 | |||
Sequence: PPKDSEVE → DGAHGGCV | ||||||
Alternative sequence | VSP_004217 | 372-746 | in isoform 5 and isoform 6 | |||
Sequence: Missing | ||||||
Sequence conflict | 416 | in Ref. 4; AAD33915/AAD33914 | ||||
Sequence: D → N | ||||||
Compositional bias | 557-574 | Polar residues | ||||
Sequence: QGTQGASSPRSSPSHTIS | ||||||
Alternative sequence | VSP_004218 | 559-567 | in isoform 4 and isoform 7 | |||
Sequence: TQGASSPRS → VSYVPYCRS | ||||||
Alternative sequence | VSP_004221 | 559-570 | in isoform 3 | |||
Sequence: TQGASSPRSSPS → VMHEIIPLEERT | ||||||
Alternative sequence | VSP_004220 | 560-561 | in isoform 2 | |||
Sequence: QG → R | ||||||
Alternative sequence | VSP_004219 | 568-746 | in isoform 4 and isoform 7 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_004222 | 571-746 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X95226 EMBL· GenBank· DDBJ | CAA64518.1 EMBL· GenBank· DDBJ | mRNA | ||
X95227 EMBL· GenBank· DDBJ | CAA64519.1 EMBL· GenBank· DDBJ | mRNA | ||
Z79787 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79788 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79789 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79790 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79791 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79792 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79793 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79794 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79795 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79796 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z79797 EMBL· GenBank· DDBJ | CAB02145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ009669 EMBL· GenBank· DDBJ | CAA08770.1 EMBL· GenBank· DDBJ | mRNA | ||
AF143544 EMBL· GenBank· DDBJ | AAD33915.1 EMBL· GenBank· DDBJ | mRNA | ||
AF143543 EMBL· GenBank· DDBJ | AAD33914.1 EMBL· GenBank· DDBJ | mRNA | ||
AF143542 EMBL· GenBank· DDBJ | AAD33913.1 EMBL· GenBank· DDBJ | mRNA | ||
AK019477 EMBL· GenBank· DDBJ | BAB31746.1 EMBL· GenBank· DDBJ | mRNA |