Q9D1S1 · Q9D1S1_MOUSE

  • Protein
    Ubiquitin-conjugating enzyme E2 D3
  • Gene
    Ube2d3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
    EC:2.3.2.23 (UniProtKB | ENZYME | Rhea)
  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.24 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification.

Features

Showing features for active site.

114720406080100120140
TypeIDPosition(s)Description
Active site85Glycyl thioester intermediate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functiontransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-conjugating enzyme E2 D3
  • EC number
  • Alternative names
    • (E3-independent) E2 ubiquitin-conjugating enzyme D3
    • E2 ubiquitin-conjugating enzyme D3
    • Ubiquitin carrier protein D3
    • Ubiquitin-protein ligase D3

Gene names

    • Name
      Ube2d3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D1S1

Organism-specific databases

Interaction

Subunit

Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1. Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-147UBC core

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    147
  • Mass (Da)
    16,629
  • Last updated
    2001-06-01 v1
  • Checksum
    9ED74A8A738EFFAA
MALKRINKELSDLARDPPAQCSAGPVGDGMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK003163
EMBL· GenBank· DDBJ
BAB22614.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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