Q9D0T7 · GKN3_MOUSE

  • Protein
    Gastrokine-3
  • Gene
    Gkn3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Inhibits gastric epithelial cell proliferation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Biological Processnegative regulation of epithelial cell proliferation

Names & Taxonomy

Protein names

  • Recommended name
    Gastrokine-3

Gene names

    • Name
      Gkn3

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D0T7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis147Impaired secretion.
Mutagenesis171Impaired secretion.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-30
ChainPRO_000039447431-191Gastrokine-3
Glycosylation33N-linked (GlcNAc...) asparagine
Disulfide bond90↔147

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in stomach. Present in mucus cells at the base of antral glands, and Brunner glands of the duodenum. Present at lower levels in the mucus neck cell region of the fundus (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain63-155BRICHOS

Sequence similarities

Belongs to the gastrokine family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    191
  • Mass (Da)
    20,772
  • Last updated
    2001-06-01 v1
  • Checksum
    76D7DB4796AE8B4D
MPLHSLERDNMRRLIAPSILVTVFLVPALALTNTSDSYPLDGSVGTQTIHVDALRGVVSIRDNSVQSEWDGVMDYKNDLLAAKLFSKMACVLAKMDPAAFPSLDDITQALGKQASGHYPPTRGLTYTVLPSRIKNLAQYGVPIKDLCRAVPTYFARQQKEGTALTMDPDSCSELQLLSFMGLSICGEIPGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU220566
EMBL· GenBank· DDBJ
ADB22387.1
EMBL· GenBank· DDBJ
mRNA
FN600638
EMBL· GenBank· DDBJ
CBI70313.1
EMBL· GenBank· DDBJ
mRNA
AK004474
EMBL· GenBank· DDBJ
BAB23320.1
EMBL· GenBank· DDBJ
mRNA
CH466523
EMBL· GenBank· DDBJ
EDK99205.1
EMBL· GenBank· DDBJ
Genomic DNA
BC116955
EMBL· GenBank· DDBJ
AAI16956.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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