Q9D0K1 · PEX13_MOUSE
- ProteinPeroxisomal membrane protein PEX13
- GenePex13
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids405 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity).
The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity).
Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity).
The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity).
Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | peroxisomal importomer complex | |
Cellular Component | peroxisomal membrane | |
Cellular Component | peroxisome | |
Molecular Function | peroxisome targeting sequence binding | |
Molecular Function | protein transmembrane transporter activity | |
Biological Process | cellular response to reactive oxygen species | |
Biological Process | cerebral cortex cell migration | |
Biological Process | fatty acid alpha-oxidation | |
Biological Process | locomotory behavior | |
Biological Process | microtubule-based peroxisome localization | |
Biological Process | neuron migration | |
Biological Process | protein import into peroxisome matrix, docking | |
Biological Process | protein import into peroxisome matrix, translocation | |
Biological Process | suckling behavior |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal membrane protein PEX13
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9D0K1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Peroxisome membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-136 | Peroxisomal matrix | ||||
Sequence: MASQPPPPPKPWESRRIPGAGPGPGSGPGPTYQSADLGPTLLTRPGQPTLTRVPPPILPRPSQQTGSNNVNTFRPAYSSFSSGYGAYGNSFYGSYSPYSYGYNGLGFNRLRVDDLPPSRFVQQAEESSRGAFQSIE | ||||||
Transmembrane | 137-157 | Helical | ||||
Sequence: SIVHAFASVSMMMDATFSAVY | ||||||
Topological domain | 158-176 | Cytoplasmic | ||||
Sequence: NSFRAVLDVANHFSRLKIH | ||||||
Transmembrane | 177-194 | Helical | ||||
Sequence: FTKVFSAFALVRTIRYLY | ||||||
Topological domain | 195-235 | Peroxisomal matrix | ||||
Sequence: RRLQWMMGLRRGSENEDLWAESEGTVACLSAEDQATNSAKS | ||||||
Transmembrane | 236-256 | Helical | ||||
Sequence: WPIFLFFAVILGGPYLIWKLL | ||||||
Topological domain | 257-405 | Cytoplasmic | ||||
Sequence: STHNDEVTDNTNWASGEDDHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRRGRKTIESSTMLKQQQSFTNPTLIKGVTTTNPLDEQEAAFESVFVETNKVSSAPDSTGKNGDKQDL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000240662 | 1-405 | Peroxisomal membrane protein PEX13 | |||
Sequence: MASQPPPPPKPWESRRIPGAGPGPGSGPGPTYQSADLGPTLLTRPGQPTLTRVPPPILPRPSQQTGSNNVNTFRPAYSSFSSGYGAYGNSFYGSYSPYSYGYNGLGFNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMMGLRRGSENEDLWAESEGTVACLSAEDQATNSAKSWPIFLFFAVILGGPYLIWKLLSTHNDEVTDNTNWASGEDDHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRRGRKTIESSTMLKQQQSFTNPTLIKGVTTTNPLDEQEAAFESVFVETNKVSSAPDSTGKNGDKQDL | ||||||
Modified residue | 356 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Pro residues | ||||
Sequence: MASQPPPPPKPWESR | ||||||
Region | 1-71 | Disordered | ||||
Sequence: MASQPPPPPKPWESRRIPGAGPGPGSGPGPTYQSADLGPTLLTRPGQPTLTRVPPPILPRPSQQTGSNNVN | ||||||
Region | 147-235 | Targeting to peroxisomes | ||||
Sequence: MMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMMGLRRGSENEDLWAESEGTVACLSAEDQATNSAKS | ||||||
Region | 177-198 | Interaction with PEX19 | ||||
Sequence: FTKVFSAFALVRTIRYLYRRLQ | ||||||
Domain | 274-338 | SH3 | ||||
Sequence: DDHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGK |
Sequence similarities
Belongs to the peroxin-13 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length405
- Mass (Da)44,610
- Last updated2001-06-01 v1
- Checksum4ABF0463211AA466
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D6RH41 | D6RH41_MOUSE | Pex13 | 40 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Pro residues | ||||
Sequence: MASQPPPPPKPWESR | ||||||
Sequence conflict | 177 | in Ref. 2; CAC20705 | ||||
Sequence: F → C | ||||||
Sequence conflict | 200 | in Ref. 3; BAC27635 | ||||
Sequence: M → K | ||||||
Sequence conflict | 203 | in Ref. 2; CAC20705 | ||||
Sequence: L → I | ||||||
Sequence conflict | 206 | in Ref. 2; CAC20705 | ||||
Sequence: G → S | ||||||
Sequence conflict | 227 | in Ref. 3; BAE31995 | ||||
Sequence: D → N | ||||||
Sequence conflict | 239-241 | in Ref. 2; CAC20705 | ||||
Sequence: FLF → ILS | ||||||
Sequence conflict | 291 | in Ref. 3; BAE31995 | ||||
Sequence: E → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF329877 EMBL· GenBank· DDBJ | AAK15313.2 EMBL· GenBank· DDBJ | mRNA | ||
AJ304506 EMBL· GenBank· DDBJ | CAC20705.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011355 EMBL· GenBank· DDBJ | BAB27563.1 EMBL· GenBank· DDBJ | mRNA | ||
AK029099 EMBL· GenBank· DDBJ | BAC26296.1 EMBL· GenBank· DDBJ | mRNA | ||
AK029336 EMBL· GenBank· DDBJ | BAC26402.1 EMBL· GenBank· DDBJ | mRNA | ||
AK031710 EMBL· GenBank· DDBJ | BAC27526.1 EMBL· GenBank· DDBJ | mRNA | ||
AK031975 EMBL· GenBank· DDBJ | BAC27635.1 EMBL· GenBank· DDBJ | mRNA | ||
AK032650 EMBL· GenBank· DDBJ | BAC27971.1 EMBL· GenBank· DDBJ | mRNA | ||
AK153438 EMBL· GenBank· DDBJ | BAE31995.1 EMBL· GenBank· DDBJ | mRNA | ||
AK169148 EMBL· GenBank· DDBJ | BAE40927.1 EMBL· GenBank· DDBJ | mRNA | ||
BC023683 EMBL· GenBank· DDBJ | AAH23683.1 EMBL· GenBank· DDBJ | mRNA |