Q9D0K1 · PEX13_MOUSE

  • Protein
    Peroxisomal membrane protein PEX13
  • Gene
    Pex13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity).
The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity).
Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentperoxisomal importomer complex
Cellular Componentperoxisomal membrane
Cellular Componentperoxisome
Molecular Functionperoxisome targeting sequence binding
Molecular Functionprotein transmembrane transporter activity
Biological Processcellular response to reactive oxygen species
Biological Processcerebral cortex cell migration
Biological Processfatty acid alpha-oxidation
Biological Processlocomotory behavior
Biological Processmicrotubule-based peroxisome localization
Biological Processneuron migration
Biological Processprotein import into peroxisome matrix, docking
Biological Processprotein import into peroxisome matrix, translocation
Biological Processsuckling behavior

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisomal membrane protein PEX13
  • Alternative names
    • Peroxin-13

Gene names

    • Name
      Pex13

Organism names

  • Taxonomic identifier
  • Strains
    • 129/SvJ
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D0K1
  • Secondary accessions
    • Q3U5T1
    • Q8CCJ5
    • Q8CCW5
    • Q99MM2
    • Q9EPK1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-136Peroxisomal matrix
Transmembrane137-157Helical
Topological domain158-176Cytoplasmic
Transmembrane177-194Helical
Topological domain195-235Peroxisomal matrix
Transmembrane236-256Helical
Topological domain257-405Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002406621-405Peroxisomal membrane protein PEX13
Modified residue356Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex. Interacts with PEX19.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-15Pro residues
Region1-71Disordered
Region147-235Targeting to peroxisomes
Region177-198Interaction with PEX19
Domain274-338SH3

Sequence similarities

Belongs to the peroxin-13 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    44,610
  • Last updated
    2001-06-01 v1
  • Checksum
    4ABF0463211AA466
MASQPPPPPKPWESRRIPGAGPGPGSGPGPTYQSADLGPTLLTRPGQPTLTRVPPPILPRPSQQTGSNNVNTFRPAYSSFSSGYGAYGNSFYGSYSPYSYGYNGLGFNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMMGLRRGSENEDLWAESEGTVACLSAEDQATNSAKSWPIFLFFAVILGGPYLIWKLLSTHNDEVTDNTNWASGEDDHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRRGRKTIESSTMLKQQQSFTNPTLIKGVTTTNPLDEQEAAFESVFVETNKVSSAPDSTGKNGDKQDL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D6RH41D6RH41_MOUSEPex1340

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-15Pro residues
Sequence conflict177in Ref. 2; CAC20705
Sequence conflict200in Ref. 3; BAC27635
Sequence conflict203in Ref. 2; CAC20705
Sequence conflict206in Ref. 2; CAC20705
Sequence conflict227in Ref. 3; BAE31995
Sequence conflict239-241in Ref. 2; CAC20705
Sequence conflict291in Ref. 3; BAE31995

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF329877
EMBL· GenBank· DDBJ
AAK15313.2
EMBL· GenBank· DDBJ
mRNA
AJ304506
EMBL· GenBank· DDBJ
CAC20705.1
EMBL· GenBank· DDBJ
mRNA
AK011355
EMBL· GenBank· DDBJ
BAB27563.1
EMBL· GenBank· DDBJ
mRNA
AK029099
EMBL· GenBank· DDBJ
BAC26296.1
EMBL· GenBank· DDBJ
mRNA
AK029336
EMBL· GenBank· DDBJ
BAC26402.1
EMBL· GenBank· DDBJ
mRNA
AK031710
EMBL· GenBank· DDBJ
BAC27526.1
EMBL· GenBank· DDBJ
mRNA
AK031975
EMBL· GenBank· DDBJ
BAC27635.1
EMBL· GenBank· DDBJ
mRNA
AK032650
EMBL· GenBank· DDBJ
BAC27971.1
EMBL· GenBank· DDBJ
mRNA
AK153438
EMBL· GenBank· DDBJ
BAE31995.1
EMBL· GenBank· DDBJ
mRNA
AK169148
EMBL· GenBank· DDBJ
BAE40927.1
EMBL· GenBank· DDBJ
mRNA
BC023683
EMBL· GenBank· DDBJ
AAH23683.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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