Q9CZM9 · KCMB2_MOUSE
- ProteinCalcium-activated potassium channel subunit beta-2
- GeneKcnmb2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids235 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated potassium channel complex | |
Molecular Function | calcium-activated potassium channel activity | |
Molecular Function | potassium channel activity | |
Molecular Function | potassium channel regulator activity | |
Biological Process | detection of calcium ion | |
Biological Process | neuronal action potential |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-activated potassium channel subunit beta-2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CZM9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-46 | Cytoplasmic | ||||
Sequence: MFIWTSGRTSSSYRQDEKRNIYQKIRDHDLLDKRKTVTALKAGEDR | ||||||
Transmembrane | 47-67 | Helical; Name=1 | ||||
Sequence: AILLGLAMMVCSIMMYFLLGI | ||||||
Topological domain | 68-194 | Extracellular | ||||
Sequence: TLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGERLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSN | ||||||
Transmembrane | 195-215 | Helical; Name=2 | ||||
Sequence: VLFHSLFWPTCMMAGGVAIVA | ||||||
Topological domain | 216-235 | Cytoplasmic | ||||
Sequence: MVKLTQYLSLLCERIQRINR |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000187052 | 1-235 | Calcium-activated potassium channel subunit beta-2 | |||
Sequence: MFIWTSGRTSSSYRQDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQCALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGERLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR | ||||||
Glycosylation | 88 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 96 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 119 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
N-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-45 | Ball and chain | ||||
Sequence: MFIWTSGRTSSSYRQDEKRNIYQKIRDHDLLDKRKTVTALKAGED |
Domain
The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus (By similarity).
Sequence similarities
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length235
- Mass (Da)27,120
- Last updated2001-06-01 v1
- ChecksumF87D3D91C22BBDF2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0A6YXE4 | A0A0A6YXE4_MOUSE | Kcnmb2 | 181 | ||
B5BNW2 | B5BNW2_MOUSE | Kcnmb2 | 36 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY062429 EMBL· GenBank· DDBJ | AAL38982.1 EMBL· GenBank· DDBJ | mRNA | ||
AK012400 EMBL· GenBank· DDBJ | BAB28216.1 EMBL· GenBank· DDBJ | mRNA | ||
BC046227 EMBL· GenBank· DDBJ | AAH46227.1 EMBL· GenBank· DDBJ | mRNA | ||
BC058957 EMBL· GenBank· DDBJ | AAH58957.1 EMBL· GenBank· DDBJ | mRNA |