Q9CYH2 · PXL2A_MOUSE
- ProteinPeroxiredoxin-like 2A
- GenePrxl2a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids218 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in redox regulation of the cell (By similarity).
Acts as an antioxidant (By similarity).
Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity).
May affect bone resorption and help to maintain bone mass (By similarity).
Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
Acts as an antioxidant (By similarity).
Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity).
May affect bone resorption and help to maintain bone mass (By similarity).
Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
Miscellaneous
The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 74 | Redox-active | ||||
Sequence: C | ||||||
Active site | 77 | Redox-active | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | mitochondrion | |
Molecular Function | antioxidant activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended namePeroxiredoxin-like 2A
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CYH2
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000019551 | 1-218 | Peroxiredoxin-like 2A | |||
Sequence: MGMWSIGVGAVGAAAVALLLANTDMFLSKPRKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEQVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMFMGLIRLGVWYNSFRAWNGGFSGNLEGEGFILGGVFVIGSGKQGILLEHREKEFGDRVNPLSVLEAVKKIKLQTPASGRS |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 3-101 | Thioredoxin-like fold | ||||
Sequence: MWSIGVGAVGAAAVALLLANTDMFLSKPRKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAV |
Sequence similarities
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length218
- Mass (Da)24,395
- Last updated2003-03-01 v2
- ChecksumA59CC8F53FACBC4C
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK017688 EMBL· GenBank· DDBJ | BAB30875.2 EMBL· GenBank· DDBJ | mRNA | ||
BC056635 EMBL· GenBank· DDBJ | AAH56635.1 EMBL· GenBank· DDBJ | mRNA |