Q9CYH2 · PXL2A_MOUSE

  • Protein
    Peroxiredoxin-like 2A
  • Gene
    Prxl2a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Involved in redox regulation of the cell (By similarity).
Acts as an antioxidant (By similarity).
Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity).
May affect bone resorption and help to maintain bone mass (By similarity).
Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).

Miscellaneous

The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.

Features

Showing features for active site.

121820406080100120140160180200
TypeIDPosition(s)Description
Active site74Redox-active
Active site77Redox-active

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentmitochondrion
Molecular Functionantioxidant activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-like 2A
  • Alternative names
    • Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
      (Protein PAMM
      )
    • Redox-regulatory protein FAM213A

Gene names

    • Name
      Prxl2a
    • Synonyms
      Fam213a
      , Pamm

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9CYH2

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Secreted
Note: Secreted from mature adipocytes but not from preadipocytes.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000195511-218Peroxiredoxin-like 2A

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in kidney, liver, skin, and brain (PubMed:19951071).
Widely expressed with highest levels detected in adipose tissue (PubMed:26438880).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region3-101Thioredoxin-like fold

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    24,395
  • Last updated
    2003-03-01 v2
  • Checksum
    A59CC8F53FACBC4C
MGMWSIGVGAVGAAAVALLLANTDMFLSKPRKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEQVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMFMGLIRLGVWYNSFRAWNGGFSGNLEGEGFILGGVFVIGSGKQGILLEHREKEFGDRVNPLSVLEAVKKIKLQTPASGRS

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q3U125Q3U125_MOUSEPrxl2a229
D3YYG8D3YYG8_MOUSEPrxl2a174
D3YWL4D3YWL4_MOUSEPrxl2a89
D3Z252D3Z252_MOUSEPrxl2a203
D3Z143D3Z143_MOUSEPrxl2a48
D3Z398D3Z398_MOUSEPrxl2a176
D3Z0A8D3Z0A8_MOUSEPrxl2a103

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK017688
EMBL· GenBank· DDBJ
BAB30875.2
EMBL· GenBank· DDBJ
mRNA
BC056635
EMBL· GenBank· DDBJ
AAH56635.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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