Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition which in turn transiently unbalances hepatocytes cell cycle progression.
These results show a significant increase in renal TNFalpha expression after tunicamycin exposure and in the oedematogenic response in Tm7sf2(-/-) mice.
several genes involved in cell-cycle progression are downregulated in the liver of Tm7sf2((-/-)) mice whereas genes involved in xenobiotic metabolism are upregulated.
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