Q9CWG9 · BL1S2_MOUSE
- ProteinBiogenesis of lysosome-related organelles complex 1 subunit 2
- GeneBloc1s2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids143 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity).
In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198).
The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860).
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198).
The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860).
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon cytoplasm | |
Cellular Component | BLOC-1 complex | |
Cellular Component | BORC complex | |
Cellular Component | centrosome | |
Cellular Component | cytoplasmic side of lysosomal membrane | |
Cellular Component | cytosol | |
Cellular Component | gamma-tubulin complex | |
Cellular Component | mitochondrion | |
Cellular Component | recycling endosome | |
Molecular Function | gamma-tubulin binding | |
Biological Process | anterograde axonal transport | |
Biological Process | anterograde synaptic vesicle transport | |
Biological Process | endosomal transport | |
Biological Process | extrinsic apoptotic signaling pathway via death domain receptors | |
Biological Process | lysosome localization | |
Biological Process | melanosome organization | |
Biological Process | mitochondrial outer membrane permeabilization | |
Biological Process | neuron projection development | |
Biological Process | organelle transport along microtubule | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of endosome size | |
Biological Process | regulation of lysosome size |
Names & Taxonomy
Protein names
- Recommended nameBiogenesis of lysosome-related organelles complex 1 subunit 2
- Short namesBLOC-1 subunit 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CWG9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the centrosomes in a microtubule-dependent manner.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000234545 | 2-143 | Biogenesis of lysosome-related organelles complex 1 subunit 2 | |||
Sequence: AAAAEGVPATRREEQPPRDDAAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAELQPYLDQINMIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN (PubMed:15102850).
The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198).
Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity).
Interacts with gamma-tubulin (By similarity).
Interacts with IFT57 (PubMed:18188704).
The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198).
Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity).
Interacts with gamma-tubulin (By similarity).
Interacts with IFT57 (PubMed:18188704).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-36 | Disordered | ||||
Sequence: MAAAAEGVPATRREEQPPRDDAAVETAEEAKEPAEA | ||||||
Compositional bias | 12-36 | Basic and acidic residues | ||||
Sequence: RREEQPPRDDAAVETAEEAKEPAEA | ||||||
Coiled coil | 80-128 | |||||
Sequence: EMKDIAINISRNLKDLNQKYAELQPYLDQINMIEEQVAALEQAAYKLDA |
Sequence similarities
Belongs to the BLOC1S2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length143
- Mass (Da)16,300
- Last updated2001-06-01 v1
- Checksum4E1ED89D9F1E7A4C
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A494BAG7 | A0A494BAG7_MOUSE | Bloc1s2 | 104 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 12-36 | Basic and acidic residues | ||||
Sequence: RREEQPPRDDAAVETAEEAKEPAEA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK010745 EMBL· GenBank· DDBJ | BAB27155.1 EMBL· GenBank· DDBJ | mRNA | ||
AL928960 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC065806 EMBL· GenBank· DDBJ | AAH65806.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |