Q9CTN4 · RHBT3_MOUSE
- ProteinRho-related BTB domain-containing protein 3
- GeneRhobtb3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids611 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | Golgi apparatus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | GTPase activity | |
Molecular Function | small GTPase binding | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | male gonad development | |
Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process | |
Biological Process | regulation of proteolysis | |
Biological Process | retrograde transport, endosome to Golgi |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-related BTB domain-containing protein 3
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CTN4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000198965 | 1-611 | Rho-related BTB domain-containing protein 3 | |||
Sequence: MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMTSSFHGIRPPQLEQPEKMPVLKAEASHYHSDLNNLLLCCQCVDVVFYHPEVTGVVEAHKIVLCSVSHVFMLLFNVKSPADIQDSSIIRTTQDLFAINRDAVLPGASQEAPSNPPLPVIVKDALFCSCLSDILRFIYSGAFQWEELEEDVRRKLKDSGDVSDIIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-175 | Rho-like | ||||
Sequence: MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTEGIQLAKELGATYLEL | ||||||
Domain | 254-356 | BTB 1 | ||||
Sequence: VDVVFYHPEVTGVVEAHKIVLCSVSHVFMLLFNVKSPADIQDSSIIRTTQDLFAINRDAVLPGASQEAPSNPPLPVIVKDALFCSCLSDILRFIYSGAFQWEE | ||||||
Domain | 420-487 | BTB 2 | ||||
Sequence: ADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAG | ||||||
Region | 420-611 | Interaction with Rab9 | ||||
Sequence: ADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)69,208
- Last updated2009-10-13 v3
- ChecksumF053962BD8CA1CDF
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1Y7VMM2 | A0A1Y7VMM2_MOUSE | Rhobtb3 | 100 | ||
A0A1Y7VJQ5 | A0A1Y7VJQ5_MOUSE | Rhobtb3 | 88 | ||
Q8BV11 | Q8BV11_MOUSE | Rhobtb3 | 260 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 588 | in Ref. 3; BAB24689 | ||||
Sequence: N → H |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK129234 EMBL· GenBank· DDBJ | BAC98044.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK020938 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AK006650 EMBL· GenBank· DDBJ | BAB24689.1 EMBL· GenBank· DDBJ | mRNA | ||
AK139158 EMBL· GenBank· DDBJ | BAE23906.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466563 EMBL· GenBank· DDBJ | EDL37111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC005664 EMBL· GenBank· DDBJ | AAH05664.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
BC050836 EMBL· GenBank· DDBJ | AAH50836.1 EMBL· GenBank· DDBJ | mRNA |