Q9CSR6 · Q9CSR6_MOUSE
- ProteinVery-long-chain 3-oxoacyl-CoA reductase
- GeneHsd17b12
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids130 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Catalytic activity
- (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H+ + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP+
- (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H+ + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP+
- (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H+ + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP+
- 3-oxooctadecanoyl-CoA + H+ + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP+
Pathway
Lipid metabolism; fatty acid biosynthesis.
Steroid biosynthesis; estrogen biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity | |
Biological Process | steroid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVery-long-chain 3-oxoacyl-CoA reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CSR6
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
PTM/Processing
Proteomic databases
Structure
Family & Domains
Sequence similarities
Family and domain databases
Sequence
- Sequence statusFragment
- Length130
- Mass (Da)14,715
- Last updated2001-06-01 v1
- Checksum4963686D3DE128B4
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V |