Q9CS72 · FLIP1_MOUSE
- ProteinFilamin-A-interacting protein 1
- GeneFilip1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1214 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | cytoplasm | |
Cellular Component | glutamatergic synapse | |
Cellular Component | nucleolus | |
Cellular Component | plasma membrane | |
Cellular Component | postsynapse | |
Cellular Component | postsynaptic actin cytoskeleton | |
Biological Process | modification of postsynaptic structure |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFilamin-A-interacting protein 1
- Short namesFILIP
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CS72
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000234541 | 1-1214 | Filamin-A-interacting protein 1 | |||
Sequence: MRSRNQGGESSSNGHVSCPKPSIISSDGGKGPSEDAKKNKANRKGEDDVMASGTVKRHLKPSGESEKKTKKPLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITYKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLSQRIEELEETNKSLQKAEEELQELRDKIAKGECGNSSLMAEVESLRKRVLEMEGKDEEITKTEAQCRELKKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSRSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKVELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYSLTKERDELMGKLRSEEERSCELSCSVDLLKKRLDGIEEVEREINRGRLCKGSEFTCPEDNKIRELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQMAKNKAIEKGEAVSQEAELRHRFRMEEAKSRDLQAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEETKNKNMGREVLNLTKELELSKRYSRALRPSGNGRRMVDVPVASTGVQTEAVCGDAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPMERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSAPQEKGPRPNQGTGHPGELVLAPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMSQKPKSADPTLGPERAMSPVTITTISREKSPEGGRGAFADRPASPIQIMTVSTSAAPPEIAVSPDSQEVPMGRTILKVTPEKQTVPTPMRKYNANANIITTEDNKIHIHLGSQFKRSPGPAAAEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGANKVTSTITITPVTTSSTRGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFQPRAETQSMKIELKKSAASSTASLGGGKG | ||||||
Modified residue | 138 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 979 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-20 | Polar residues | ||||
Sequence: MRSRNQGGESSSNGHVSCPK | ||||||
Region | 1-73 | Disordered | ||||
Sequence: MRSRNQGGESSSNGHVSCPKPSIISSDGGKGPSEDAKKNKANRKGEDDVMASGTVKRHLKPSGESEKKTKKPL | ||||||
Compositional bias | 31-73 | Basic and acidic residues | ||||
Sequence: GPSEDAKKNKANRKGEDDVMASGTVKRHLKPSGESEKKTKKPL | ||||||
Coiled coil | 192-581 | |||||
Sequence: DYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITYKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLSQRIEELEETNKSLQKAEEELQELRDKIAKGECGNSSLMAEVESLRKRVLEMEGKDEEITKTEAQCRELKKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSRSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKVELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYSLTKERDELMGKLRS | ||||||
Coiled coil | 624-778 | |||||
Sequence: PEDNKIRELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQMAKNKAIEKGEAVSQEAELRHRFRMEEAKSRDLQAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEETKNKNMGREVLNLTKELEL | ||||||
Region | 875-898 | Disordered | ||||
Sequence: KRENGPSAPQEKGPRPNQGTGHPG | ||||||
Compositional bias | 949-966 | Polar residues | ||||
Sequence: KPRITIIPSPNVMSQKPK | ||||||
Region | 949-976 | Disordered | ||||
Sequence: KPRITIIPSPNVMSQKPKSADPTLGPER | ||||||
Compositional bias | 1104-1160 | Polar residues | ||||
Sequence: VSTGTVLRSPRNHLSSRPGANKVTSTITITPVTTSSTRGTQSVSGQDGSSQRPTPTR | ||||||
Region | 1104-1192 | Disordered | ||||
Sequence: VSTGTVLRSPRNHLSSRPGANKVTSTITITPVTTSSTRGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFQPRAETQ |
Sequence similarities
Belongs to the FILIP1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,214
- Mass (Da)137,913
- Last updated2022-10-12 v3
- ChecksumA9520AE0804C5E4A
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8MPD6 | A0A5F8MPD6_MOUSE | Filip1 | 1178 | ||
G3UZB6 | G3UZB6_MOUSE | Filip1 | 225 | ||
A0A1L1SQQ4 | A0A1L1SQQ4_MOUSE | Filip1 | 51 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-20 | Polar residues | ||||
Sequence: MRSRNQGGESSSNGHVSCPK | ||||||
Compositional bias | 31-73 | Basic and acidic residues | ||||
Sequence: GPSEDAKKNKANRKGEDDVMASGTVKRHLKPSGESEKKTKKPL | ||||||
Compositional bias | 949-966 | Polar residues | ||||
Sequence: KPRITIIPSPNVMSQKPK | ||||||
Compositional bias | 1104-1160 | Polar residues | ||||
Sequence: VSTGTVLRSPRNHLSSRPGANKVTSTITITPVTTSSTRGTQSVSGQDGSSQRPTPTR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC140247 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC127318 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC125581 EMBL· GenBank· DDBJ | AAI25582.1 EMBL· GenBank· DDBJ | mRNA | ||
BC131965 EMBL· GenBank· DDBJ | AAI31966.1 EMBL· GenBank· DDBJ | mRNA | ||
AK017709 EMBL· GenBank· DDBJ | BAB30888.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |