Q9CR75 · TNR12_MOUSE

  • Protein
    Tumor necrosis factor receptor superfamily member 12A
  • Gene
    Tnfrsf12a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Receptor for TNFSF12/TWEAK (By similarity).
Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentplasma membrane
Cellular Componentruffle
Biological Processangiogenesis
Biological Processcell adhesion
Biological Processcell differentiation
Biological Processextrinsic apoptotic signaling pathway
Biological Processpositive regulation of axon extension
Biological Processpositive regulation of extrinsic apoptotic signaling pathway
Biological Processregulation of angiogenesis
Biological Processsubstrate-dependent cell migration, cell attachment to substrate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tumor necrosis factor receptor superfamily member 12A
  • Alternative names
    • Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14)
    • Fibroblast growth factor-regulated protein 2
    • Tweak-receptor (TweakR)
  • CD Antigen Name
    • CD266

Gene names

    • Name
      Tnfrsf12a
    • Synonyms
      Fgfrp2, Fn14

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9CR75
  • Secondary accessions
    • Q3TVG8
    • Q9QZW3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain28-80Extracellular
Transmembrane81-101Helical
Topological domain102-129Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000003461228-129Tumor necrosis factor receptor superfamily member 12A
Disulfide bond36↔49
Disulfide bond52↔67
Disulfide bond55↔64

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in fetal heart, intestine, kidney, liver, lung and skin, and in adult heart and ovary. Intermediate expression in adult kidney, lung and skin.

Induction

By FGF-1.

Gene expression databases

Interaction

Subunit

Associates with TRAF1 and TRAF2, and probably also with TRAF3.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat36-67TNFR-Cys; atypical

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    129
  • Mass (Da)
    13,641
  • Last updated
    2001-06-01 v1
  • Checksum
    1665C68B4D9A9253
MASAWPRSLPQILVLGFGLVLMRAAAGEQAPGTSPCSSGSSWSADLDKCMDCASCPARPHSDFCLGCAAAPPAHFRLLWPILGGALSLVLVLALVSSFLVWRRCRRREKFTTPIEETGGEGCPGVALIQ

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PZT5E9PZT5_MOUSETnfrsf12a94
A0A3B2W7Y2A0A3B2W7Y2_MOUSETnfrsf12a139
A0A3B2W475A0A3B2W475_MOUSETnfrsf12a83

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict3-4in Ref. 1; AAF07882

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF156164
EMBL· GenBank· DDBJ
AAF07882.1
EMBL· GenBank· DDBJ
mRNA
AK005382
EMBL· GenBank· DDBJ
BAB23989.1
EMBL· GenBank· DDBJ
mRNA
AK005530
EMBL· GenBank· DDBJ
BAB24101.1
EMBL· GenBank· DDBJ
mRNA
AK160136
EMBL· GenBank· DDBJ
BAE35650.1
EMBL· GenBank· DDBJ
mRNA
BC025860
EMBL· GenBank· DDBJ
AAH25860.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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