Q9CQ61 · UNC50_MOUSE
- ProteinProtein unc-50 homolog
- GeneUnc50
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids259 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Involved in the cell surface expression of neuronal nicotinic receptors (By similarity).
Binds RNA (By similarity).
Binds RNA (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | nuclear inner membrane | |
Molecular Function | RNA binding | |
Biological Process | protein localization to cell surface |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameProtein unc-50 homolog
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9CQ61
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Nucleus inner membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-82 | Cytoplasmic | ||||
Sequence: MLPSTSLSSSMHGNGVLNSRDAARHTAGAKRYKYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVYRNFHYRKQTKDQWARDDP | ||||||
Transmembrane | 83-103 | Helical | ||||
Sequence: AFLVLLSIWLCVSTIGFGFVL | ||||||
Topological domain | 104-112 | Lumenal | ||||
Sequence: DMGFFETIK | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: LLLWVVFIDCVGVGLLISTLM | ||||||
Topological domain | 134-163 | Cytoplasmic | ||||
Sequence: WFVSNKYLVKRQSRDYDVEWGYAFDVHLNA | ||||||
Transmembrane | 164-184 | Helical | ||||
Sequence: FYPLLVILHFIQLFFINHVIL | ||||||
Topological domain | 185-187 | Lumenal | ||||
Sequence: TDT | ||||||
Transmembrane | 188-208 | Helical | ||||
Sequence: FIGYLVGNTLWLIAVGYYIYV | ||||||
Topological domain | 209-222 | Cytoplasmic | ||||
Sequence: TFLGYSALPFLKNT | ||||||
Transmembrane | 223-243 | Helical | ||||
Sequence: VILLYPFAPLMVLYGLSLALG | ||||||
Topological domain | 244-259 | Lumenal | ||||
Sequence: WNFTHTLCSFYKYRVK |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000308962 | 1-259 | Protein unc-50 homolog | |||
Sequence: MLPSTSLSSSMHGNGVLNSRDAARHTAGAKRYKYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVYRNFHYRKQTKDQWARDDPAFLVLLSIWLCVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLLISTLMWFVSNKYLVKRQSRDYDVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYLVGNTLWLIAVGYYIYVTFLGYSALPFLKNTVILLYPFAPLMVLYGLSLALGWNFTHTLCSFYKYRVK | ||||||
Modified residue | 6 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in periodontal ligament and bone marrow, but not in gingival fibroblasts.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)30,429
- Last updated2001-06-01 v1
- ChecksumC11FD3CD95FBD4A6
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0A6YWQ8 | A0A0A6YWQ8_MOUSE | Unc50 | 86 | ||
A0A0A6YX35 | A0A0A6YX35_MOUSE | Unc50 | 170 | ||
D3YXX4 | D3YXX4_MOUSE | Unc50 | 214 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY017214 EMBL· GenBank· DDBJ | AAK08986.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003273 EMBL· GenBank· DDBJ | BAB22683.1 EMBL· GenBank· DDBJ | mRNA | ||
AK004433 EMBL· GenBank· DDBJ | BAB23302.1 EMBL· GenBank· DDBJ | mRNA | ||
AK132757 EMBL· GenBank· DDBJ | BAE21338.1 EMBL· GenBank· DDBJ | mRNA | ||
AK135885 EMBL· GenBank· DDBJ | BAE22715.1 EMBL· GenBank· DDBJ | mRNA | ||
BC019484 EMBL· GenBank· DDBJ | AAH19484.1 EMBL· GenBank· DDBJ | mRNA |