Q9CPH0 · NAGZ_PASMU

Function

function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

Catalytic activity

  • Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
    EC:3.2.1.52 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan recycling.

Features

Showing features for binding site, site, active site.

135150100150200250300350
Type
IDPosition(s)Description
Binding site62substrate
Binding site70substrate
Binding site134substrate
Binding site164-165substrate
Site175Important for catalytic activity
Active site177Proton donor/acceptor
Active site249Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionbeta-N-acetylhexosaminidase activity
Molecular FunctionN-acetyl-beta-D-galactosaminidase activity
Biological Processcarbohydrate metabolic process
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processpeptidoglycan turnover
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GH3Glycoside Hydrolase Family 3

Names & Taxonomy

Protein names

  • Recommended name
    Beta-hexosaminidase
  • EC number
  • Alternative names
    • Beta-N-acetylhexosaminidase
    • N-acetyl-beta-glucosaminidase

Gene names

    • Name
      nagZ
    • Ordered locus names
      PM0071

Organism names

Accessions

  • Primary accession
    Q9CPH0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002107931-351Beta-hexosaminidase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    39,667
  • Last updated
    2001-05-04 v1
  • Checksum
    320783A173611205
MSTLLIDLQGQELSQEEVELLSHPLVAGLILFTRNFHDRAQMQALIQSIRQRVKKPLLITVDQEGGRVQRFREGFTQLPAMQAFACLIDDPVQQTNMAQQAGWQMAAEMTALGIDLSFAPVLDLGHQCQAIGDRSFHSQAEMTLNLASAFIDGMHQVGMAATGKHFPGHGHVIADSHLETPYDERPKQQIFAQDIQPFQQLIQQNMLNAIMPAHVIYSQCDPQPASGSAYWLKQVLRQQLGFNGAIFSDDLGMKGAGFMGNFVQRCEQSLQAGCDLLLLCNEREGVIQVLDNLKLSETEPHFALRQQRLQQLFKRKTIRWSELEATSRWLENRKILTALQQRWLDNKANKH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004439
EMBL· GenBank· DDBJ
AAK02155.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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