Q9C826 · ABA2_ARATH
- ProteinXanthoxin dehydrogenase
- GeneABA2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids285 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the biosynthesis of abscisic acid (PubMed:10972885, PubMed:12172025, PubMed:12417697, PubMed:9159947).
Catalyzes the conversion of xanthoxin to abscisic aldehyde (PubMed:12172025, PubMed:12417697, PubMed:9159947).
Catalyzes the conversion of xanthoxin to abscisic aldehyde (PubMed:12172025, PubMed:12417697, PubMed:9159947).
Miscellaneous
The biological substrate is probably 2-cis,4-trans-xanthoxin.
Catalytic activity
- 2-cis,4-trans-xanthoxin + NAD+ = 2-cis-+-abscisic aldehyde + H+ + NADHThis reaction proceeds in the forward direction.
- 2-trans,4-trans-xanthoxin + NAD+ = 2-trans-+-abscisic aldehyde + H+ + NADHThis reaction proceeds in the forward direction.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
19 μM | xanthoxin | |||||
10 mM | 3,5,5'-trimethylcyclohexanol |
no activity with xanthoxic acid, ethanol, isopropanol, butanol, cyclohexanol and 2,6-dimethylcyclohexanol.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | alcohol dehydrogenase (NAD+) activity | |
Molecular Function | identical protein binding | |
Molecular Function | xanthoxin dehydrogenase (NAD+) activity | |
Biological Process | abscisic acid biosynthetic process | |
Biological Process | proline biosynthetic process | |
Biological Process | regulation of abscisic acid biosynthetic process | |
Biological Process | response to fructose | |
Biological Process | response to heat | |
Biological Process | response to water deprivation | |
Biological Process | sugar mediated signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameXanthoxin dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9C826
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 28 | In aba2-12/sre1-2; reduced absicic acid synthesis. | ||||
Sequence: G → R | ||||||
Mutagenesis | 45 | In aba2-4/sis4-2; reduced absicic acid synthesis. | ||||
Sequence: A → V | ||||||
Mutagenesis | 145 | In gin1-2; reduced absicic acid synthesis. | ||||
Sequence: R → C | ||||||
Mutagenesis | 162 | In aba2-3/sis4-1; reduced absicic acid synthesis. | ||||
Sequence: G → R | ||||||
Mutagenesis | 176 | In aba2-13/san3-1; reduced absicic acid synthesis. | ||||
Sequence: S → F | ||||||
Mutagenesis | 236 | In isi4; reduced absicic acid synthesis. | ||||
Sequence: A → V | ||||||
Mutagenesis | 264 | In aba2-1; reduced absicic acid synthesis. | ||||
Sequence: S → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000282347 | 2-285 | Xanthoxin dehydrogenase | |||
Sequence: STNTESSSYSSLPSQRLLGKVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSLLRGESKETAFFIHGDVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNVKGAFLSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIRVNCVSPYAVATKLALAHLPEEERTEDAFVGFRNFAAANANLKGVELTVDDVANAVLFLASDDSRYISGDNLMIDGGFTCTNHSFKVFR |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Predominantly in roots and stems, and at lower levels in leaves and seeds.
Induction
Constitutively expressed and not up regulated by osmotic stress.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9C826 | ABA2 Q9C826 | 6 | EBI-4464299, EBI-4464299 | |
BINARY | Q9C826 | ABCI10 Q8H1R4 | 3 | EBI-4464299, EBI-17091580 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length285
- Mass (Da)30,272
- Last updated2001-06-01 v1
- Checksum8B555DAED7386DF4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC037424 EMBL· GenBank· DDBJ | AAG51536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE32789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT003412 EMBL· GenBank· DDBJ | AAO30075.1 EMBL· GenBank· DDBJ | mRNA | ||
AY099603 EMBL· GenBank· DDBJ | AAM20454.1 EMBL· GenBank· DDBJ | mRNA | ||
AY082344 EMBL· GenBank· DDBJ | AAL99237.1 EMBL· GenBank· DDBJ | mRNA | ||
AY082345 EMBL· GenBank· DDBJ | AAL99238.1 EMBL· GenBank· DDBJ | Genomic DNA |