Q9C7S0 · BZP60_ARATH
- ProteinbZIP transcription factor 60
- GeneBZIP60
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids295 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor involved in the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Plays a role in plant immunity and abiotic stress responses.
Miscellaneous
Expression and cleavage of bZIP60 in anthers observed in the absence of stress treatment, suggesting that the ER stress response functions in the normal development of active secretory cells.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | endoplasmic reticulum unfolded protein response | |
Biological Process | immune system process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namebZIP transcription factor 60
- Short namesAtbZIP60
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9C7S0
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Endoplasmic reticulum membrane ; Single-pass membrane protein
Isoform 2
Note: The bZIP domain is translocated into the nucleus in response to ER stress.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 224-244 | Helical | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype, but reduced induction of ER stress-responsive genes. Shows enhanced susceptibility to a bacterial pathogen.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 53 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000376620 | 1-295 | bZIP transcription factor 60 | ||
Proteomic databases
Expression
Tissue specificity
Expressed in seedlings, rosette and cauline leaves, stems, buds, flowers, siliques, immature seeds, anthers and pollen grains.
Induction
By tunicamycin, DTT and azetidine-2-carboxylate. Isoform 2 is induced by heat.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 101-154 | Disordered | |||
Compositional bias | 110-126 | Basic and acidic residues | |||
Domain | 140-203 | bZIP | |||
Region | 142-162 | Basic motif | |||
Region | 168-182 | Leucine-zipper | |||
Domain
The C-terminal transmembrane domain is cleaved in response to ER stress and the N-terminal fragment containing the bZIP domain is sufficient for transcription activation.
Sequence similarities
Belongs to the bZIP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9C7S0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsbZIP60u
- Length295
- Mass (Da)33,174
- Last updated2001-06-01 v1
- MD5 Checksum80E6B56A81E05C15CB5FFBDF227A1EFB
Q9C7S0-2
- Name2
- SynonymsbZIP60s
- NotePotent transcriptional activator. Induced by IRE1-1 in response to endoplasmic reticulum stress. IRE1-1 cleaves a 23-bp fragment causing a frameshift of the mRNA transcript.
- Differences from canonical
- 219-295: LLLESLLLGSLLWLLGVNFICLFPYMSHTKCCLLRPEPEKLVLNGLGSSSKPSYTGVSRRCKGSRPRMKYQILTLAA → GFPALASGSKLHLPIPLYVPHKVLPPTSRTRKAGSKRARE
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 110-126 | Basic and acidic residues | |||
Alternative sequence | VSP_046442 | 219-295 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC068324 EMBL· GenBank· DDBJ | AAG51519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE31935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY045964 EMBL· GenBank· DDBJ | AAK76638.1 EMBL· GenBank· DDBJ | mRNA | ||
AY133805 EMBL· GenBank· DDBJ | AAM91739.1 EMBL· GenBank· DDBJ | mRNA |