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Q9C7S0 · BZP60_ARATH

Function

function

Transcription factor involved in the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Plays a role in plant immunity and abiotic stress responses.

Miscellaneous

Expression and cleavage of bZIP60 in anthers observed in the absence of stress treatment, suggesting that the ER stress response functions in the normal development of active secretory cells.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionsequence-specific DNA binding
Biological Processendoplasmic reticulum unfolded protein response
Biological Processimmune system process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    bZIP transcription factor 60
  • Short names
    AtbZIP60

Gene names

    • Name
      BZIP60
    • ORF names
      F13A11.5
    • Ordered locus names
      At1g42990

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9C7S0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Isoform 1

Endoplasmic reticulum membrane ; Single-pass membrane protein

Isoform 2

Note: The bZIP domain is translocated into the nucleus in response to ER stress.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane224-244Helical

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype, but reduced induction of ER stress-responsive genes. Shows enhanced susceptibility to a bacterial pathogen.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 53 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003766201-295bZIP transcription factor 60

Proteomic databases

Expression

Tissue specificity

Expressed in seedlings, rosette and cauline leaves, stems, buds, flowers, siliques, immature seeds, anthers and pollen grains.

Induction

By tunicamycin, DTT and azetidine-2-carboxylate. Isoform 2 is induced by heat.

Gene expression databases

Interaction

Subunit

Interacts with BZIP28.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region101-154Disordered
Compositional bias110-126Basic and acidic residues
Domain140-203bZIP
Region142-162Basic motif
Region168-182Leucine-zipper

Domain

The C-terminal transmembrane domain is cleaved in response to ER stress and the N-terminal fragment containing the bZIP domain is sufficient for transcription activation.

Sequence similarities

Belongs to the bZIP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9C7S0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    bZIP60u
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    295
  • Mass (Da)
    33,174
  • Last updated
    2001-06-01 v1
  • MD5 Checksum
    80E6B56A81E05C15CB5FFBDF227A1EFB
MAEEFGSIDLLGDEDFFFDFDPSIVIDSLPAEDFLQSSPDSWIGEIENQLMNDENHQEESFVELDQQSVSDFIADLLVDYPTSDSGSVDLAADKVLTVDSPAAADDSGKENSDLVVEKKSNDSGSEIHDDDDEEGDDDAVAKKRRRRVRNRDAAVRSRERKKEYVQDLEKKSKYLERECLRLGRMLECFVAENQSLRYCLQKGNGNNTTMMSKQESAVLLLESLLLGSLLWLLGVNFICLFPYMSHTKCCLLRPEPEKLVLNGLGSSSKPSYTGVSRRCKGSRPRMKYQILTLAA

Q9C7S0-2

  • Name
    2
  • Synonyms
    bZIP60s
  • Note
    Potent transcriptional activator. Induced by IRE1-1 in response to endoplasmic reticulum stress. IRE1-1 cleaves a 23-bp fragment causing a frameshift of the mRNA transcript.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 219-295: LLLESLLLGSLLWLLGVNFICLFPYMSHTKCCLLRPEPEKLVLNGLGSSSKPSYTGVSRRCKGSRPRMKYQILTLAA → GFPALASGSKLHLPIPLYVPHKVLPPTSRTRKAGSKRARE

Features

Showing features for compositional bias, alternative sequence.

Type
IDPosition(s)Description
Compositional bias110-126Basic and acidic residues
Alternative sequenceVSP_046442219-295in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC068324
EMBL· GenBank· DDBJ
AAG51519.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE31935.1
EMBL· GenBank· DDBJ
Genomic DNA
AY045964
EMBL· GenBank· DDBJ
AAK76638.1
EMBL· GenBank· DDBJ
mRNA
AY133805
EMBL· GenBank· DDBJ
AAM91739.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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