Q9C6T1 · PMK_ARATH
- ProteinPhosphomevalonate kinase, peroxisomal
- GenePMK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids505 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
11.8 μM | (R)-5-phosphomevalonate |
kcat is 20.9 sec-1 with (R)-5-phosphomevalonate.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 177-187 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | ATP binding | |
Molecular Function | phosphomevalonate kinase activity | |
Biological Process | isopentenyl diphosphate biosynthetic process, mevalonate pathway | |
Biological Process | phosphorylation | |
Biological Process | sterol biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomevalonate kinase, peroxisomal
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9C6T1
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylalanine | |||
Chain | PRO_0000435609 | 2-505 | Phosphomevalonate kinase, peroxisomal | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 57-65 | Peroxisomal targeting signal PTS2 | |||
Sequence similarities
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9C6T1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length505
- Mass (Da)54,409
- Last updated2001-06-01 v1
- ChecksumB1CBA6CA338B3D63
Q9C6T1-2
- Name2
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 44 | in Ref. 3; BAD43274 | |||
Sequence conflict | 54 | in Ref. 3; BAD43274 | |||
Alternative sequence | VSP_058117 | 418-450 | in isoform 2 | ||
Alternative sequence | VSP_058118 | 451-505 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC079041 EMBL· GenBank· DDBJ | AAG50716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE31414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE31415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK175299 EMBL· GenBank· DDBJ | BAD43062.1 EMBL· GenBank· DDBJ | mRNA | ||
AK175308 EMBL· GenBank· DDBJ | BAD43071.1 EMBL· GenBank· DDBJ | mRNA | ||
AK175511 EMBL· GenBank· DDBJ | BAD43274.1 EMBL· GenBank· DDBJ | mRNA | ||
AK176723 EMBL· GenBank· DDBJ | BAD44486.1 EMBL· GenBank· DDBJ | mRNA | ||
AK176889 EMBL· GenBank· DDBJ | BAD44652.1 EMBL· GenBank· DDBJ | mRNA | ||
AK221797 EMBL· GenBank· DDBJ | BAD93949.1 EMBL· GenBank· DDBJ | mRNA |