Q9C5W7 · TOM2A_ARATH
- ProteinTobamovirus multiplication protein 2A
- GeneTOM2A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids280 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Necessary for the efficient intracellular multiplication of tobamoviruses, being a component of the replication complex.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | membrane | |
Cellular Component | nucleus | |
Cellular Component | plant-type vacuole | |
Cellular Component | plant-type vacuole membrane | |
Cellular Component | plasmodesma | |
Biological Process | viral replication complex formation and maintenance |
Names & Taxonomy
Protein names
- Recommended nameTobamovirus multiplication protein 2A
- Short namesAtTOM2A
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9C5W7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Vacuole membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-13 | Cytoplasmic | ||||
Sequence: MACRGCLECLLKL | ||||||
Transmembrane | 14-34 | Helical | ||||
Sequence: LNFLLAVAGLGMIGYGIYLFV | ||||||
Topological domain | 35-78 | Extracellular | ||||
Sequence: EYKRVTDNSVTFDLTNGDQSYVSFGRPILMAVSLSSNIFDNLPK | ||||||
Transmembrane | 79-99 | Helical | ||||
Sequence: AWFIYLFIGIGVALFVISCCG | ||||||
Topological domain | 100-113 | Cytoplasmic | ||||
Sequence: CVGTCSRSVCCLSC | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: YSLLLILLILVELGFAAFIFF | ||||||
Topological domain | 135-162 | Extracellular | ||||
Sequence: DNSWRDELPSDRTGNFDTIYNFLRENWK | ||||||
Transmembrane | 163-183 | Helical | ||||
Sequence: IVRWVALGAVVFEALLFLLAL | ||||||
Topological domain | 184-280 | Cytoplasmic | ||||
Sequence: MVRAANTPAEYDSDDEYLAPRQQIRQPFINRQAAPVTGVPVAPTLDQRPSRSDPWSARMREKYGLDTSEFTYNPSESHRFQQMPAQPNEEKGRCTIM |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Reduced efficiency of intracellular multiplication of tobamoviruses (e.g. crucifer strain TMV-Cg), characterized by a reduced amplification of TMV-related RNAs.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423674 | 1-280 | Tobamovirus multiplication protein 2A | |||
Sequence: MACRGCLECLLKLLNFLLAVAGLGMIGYGIYLFVEYKRVTDNSVTFDLTNGDQSYVSFGRPILMAVSLSSNIFDNLPKAWFIYLFIGIGVALFVISCCGCVGTCSRSVCCLSCYSLLLILLILVELGFAAFIFFDNSWRDELPSDRTGNFDTIYNFLRENWKIVRWVALGAVVFEALLFLLALMVRAANTPAEYDSDDEYLAPRQQIRQPFINRQAAPVTGVPVAPTLDQRPSRSDPWSARMREKYGLDTSEFTYNPSESHRFQQMPAQPNEEKGRCTIM | ||||||
Modified residue | 196 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 233 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 258-280 | Disordered | ||||
Sequence: SESHRFQQMPAQPNEEKGRCTIM |
Sequence similarities
Belongs to the tetraspanin (TM4SF) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length280
- Mass (Da)31,556
- Last updated2001-06-01 v1
- Checksum227C8FE0658A8C0C
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB085684 EMBL· GenBank· DDBJ | BAC24019.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007767 EMBL· GenBank· DDBJ | AAF81337.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE31476.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE31477.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE31478.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF334723 EMBL· GenBank· DDBJ | AAG50101.1 EMBL· GenBank· DDBJ | mRNA | ||
AF385687 EMBL· GenBank· DDBJ | AAK60280.1 EMBL· GenBank· DDBJ | mRNA | ||
AY088560 EMBL· GenBank· DDBJ | AAM66092.1 EMBL· GenBank· DDBJ | mRNA | ||
AK221090 EMBL· GenBank· DDBJ | BAD94952.1 EMBL· GenBank· DDBJ | mRNA |