Q9C2R2 · CCR4_NEUCR
- ProteinCCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- Geneccr4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids793 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).
Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic activity
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 446 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | CCR4-NOT complex | |
Cellular Component | CCR4-NOT core complex | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | P-body | |
Molecular Function | metal ion binding | |
Molecular Function | poly(A)-specific ribonuclease activity | |
Molecular Function | RNA binding | |
Biological Process | nuclear-transcribed mRNA poly(A) tail shortening |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionQ9C2R2
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000290615 | 1-793 | CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 50-78 | Polar residues | |||
Region | 50-85 | Disordered | |||
Region | 208-239 | Disordered | |||
Compositional bias | 223-239 | Basic and acidic residues | |||
Repeat | 241-264 | LRR 1 | |||
Repeat | 266-287 | LRR 2 | |||
Repeat | 289-310 | LRR 3 | |||
Repeat | 312-334 | LRR 4 | |||
Repeat | 335-354 | LRR 5 | |||
Region | 764-793 | Disordered | |||
Compositional bias | 770-793 | Polar residues | |||
Sequence similarities
Belongs to the CCR4/nocturin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length793
- Mass (Da)88,752
- Last updated2007-12-04 v2
- MD5 Checksum8F8816D21889629CB189772E3CF159E3
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 50-78 | Polar residues | |||
Compositional bias | 223-239 | Basic and acidic residues | |||
Compositional bias | 770-793 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL513410 EMBL· GenBank· DDBJ | CAC28578.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CM002240 EMBL· GenBank· DDBJ | ESA42355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM002240 EMBL· GenBank· DDBJ | ESA42356.1 EMBL· GenBank· DDBJ | Genomic DNA |