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Q9C2R2 · CCR4_NEUCR

Function

function

Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).
Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

1793100200300400500600700
TypeIDPosition(s)Description
Binding site446Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentCCR4-NOT complex
Cellular ComponentCCR4-NOT core complex
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular ComponentP-body
Molecular Functionmetal ion binding
Molecular Functionpoly(A)-specific ribonuclease activity
Molecular FunctionRNA binding
Biological Processnuclear-transcribed mRNA poly(A) tail shortening

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
  • EC number
  • Alternative names
    • Carbon catabolite repressor protein 4
    • Cytoplasmic deadenylase
    • Glucose-repressible alcohol dehydrogenase transcriptional effector

Gene names

    • Name
      ccr4
    • ORF names
      NCU07779

Organism names

Accessions

  • Primary accession
    Q9C2R2
  • Secondary accessions
    • V5ILT7

Proteomes

    • Identifier
    • Component
      Chromosome 2, Linkage Group V

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002906151-793CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, repeat.

Type
IDPosition(s)Description
Compositional bias50-78Polar residues
Region50-85Disordered
Region208-239Disordered
Compositional bias223-239Basic and acidic residues
Repeat241-264LRR 1
Repeat266-287LRR 2
Repeat289-310LRR 3
Repeat312-334LRR 4
Repeat335-354LRR 5
Region764-793Disordered
Compositional bias770-793Polar residues

Sequence similarities

Belongs to the CCR4/nocturin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    793
  • Mass (Da)
    88,752
  • Last updated
    2007-12-04 v2
  • MD5 Checksum
    8F8816D21889629CB189772E3CF159E3
MADGHRYMQQSFSTPLPTQFASNNNLATGLLLNSLLNQFIADPSAAQQQAAAQANPAHSSATQINRGMYGQNHPQGHNPRLNGAAPGRQPNMPMFYNHVPQQGHPHQGHNAHHQVLQAGHSGHGARNDLMSHSTFSSGIMGNASPYTTNNLQNGHSVAARGGPAEQPANEHWQKQMRLKEESDRAHSAMTEQHQPHYYARLKAPENKGIGGSLTAGGANASGDSEEEVRRRPYQVEKRNRRQDWHNLDMSGQGLRALSSALFSYDFLVELYIASNRLTFLPAEIGKLRHLKILEASNNLLSELPPEIGMCTSLEKLLLFDNQIRDLPYELGSLYKLDILGIEGNPINPGLREEIVERGTKSLINSLLEQAPVPLPPSPRKPIVVQEDVSPSLERIKVMTWNILCDKFATTNMYGYTPTGALSWEYRKERILQEIRDRDVDMLCLQEIATDVFRDFFSPELAQNDYKGVHWPRPKAKTMNEKDAAAVDGCAIFYKGSKWILLDKQLIDYANIAINRPDMKNQHDIFNRVMPKDNIGIICFFESRRTGARVIVANTHLAWEPTLADVKLVQTAILMENITKYAEKYVRWQPLKDKRGIQIPQSVSVESDIPKPEMPEPGPSQEYRSNTDIPLIVCGDYNSTQESSVYELLSMGRVTPEQSDFGGHQYGNFTRDGVAHPFSMRSAYVHLNGTPDELSFTNYVPGFQEVIDYIWYSTNTLEVVELLGPPDQNHLKRVPGFPNYHFPADHIQIMAEFVIKQRKGEKVKVIHGSGGGASGQQQQQQQLEGGQDFGSGSK

Sequence caution

The sequence CAC28578.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias50-78Polar residues
Compositional bias223-239Basic and acidic residues
Compositional bias770-793Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL513410
EMBL· GenBank· DDBJ
CAC28578.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CM002240
EMBL· GenBank· DDBJ
ESA42355.1
EMBL· GenBank· DDBJ
Genomic DNA
CM002240
EMBL· GenBank· DDBJ
ESA42356.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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