TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82 thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine. MKK6 could also stabilize TRIM9s by promoting the phosphorylation of TRIM9s at Ser76/80 via p38 thereby blocking the ubiquitin-proteasome pathway., Phosphorylation
TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1 leading to the activation of IRF3 signaling.
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