Q9C019 · TRI15_HUMAN
- ProteinE3 ubiquitin-protein ligase TRIM15
- GeneTRIM15
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids465 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270).
Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368).
Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296).
Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300).
Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740).
Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs)
Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368).
Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296).
Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300).
Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740).
Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs)
Catalytic activity
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | focal adhesion | |
Cellular Component | nucleus | |
Molecular Function | molecular sequestering activity | |
Molecular Function | transcription coactivator activity | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | innate immune response | |
Biological Process | mesodermal cell fate determination | |
Biological Process | negative regulation of intracellular transport of viral material | |
Biological Process | negative regulation of non-canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of DNA-binding transcription factor activity | |
Biological Process | positive regulation of NF-kappaB transcription factor activity | |
Biological Process | positive regulation of RIG-I signaling pathway | |
Biological Process | positive regulation of type I interferon production | |
Biological Process | protein ubiquitination | |
Biological Process | suppression of viral release by host |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase TRIM15
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9C019
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to focal adhesions during the early stage of adhesion biogenesis.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_014228 | 29 | in dbSNP:rs17194460 | |||
Sequence: I → V | ||||||
Natural variant | VAR_052129 | 42 | in dbSNP:rs17194467 | |||
Sequence: A → T | ||||||
Natural variant | VAR_052130 | 84 | in dbSNP:rs17194474 | |||
Sequence: E → Q | ||||||
Natural variant | VAR_052131 | 235 | in dbSNP:rs34823152 | |||
Sequence: L → V | ||||||
Natural variant | VAR_052132 | 324 | in dbSNP:rs929156 | |||
Sequence: S → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,003 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000056218 | 1-465 | E3 ubiquitin-protein ligase TRIM15 | |||
Sequence: MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with paxillin/PXN; this interaction recruits TRIM15 to focal adhesions (PubMed:25015296).
Interacts with TRIM8; this interaction prevents TRIM8 cytoplasmic translocation (PubMed:34871740).
Interacts with TRIM8; this interaction prevents TRIM8 cytoplasmic translocation (PubMed:34871740).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9C019 | AXIN1 O15169 | 3 | EBI-2342111, EBI-710484 | |
BINARY | Q9C019 | CDK6 Q00534 | 3 | EBI-2342111, EBI-295663 | |
BINARY | Q9C019 | FAM151B Q6UXP7 | 3 | EBI-2342111, EBI-8456391 | |
BINARY | Q9C019 | FAM161A Q3B820 | 3 | EBI-2342111, EBI-719941 | |
BINARY | Q9C019 | FAM161B Q96MY7 | 3 | EBI-2342111, EBI-7225287 | |
BINARY | Q9C019 | RABGEF1 Q9UJ41 | 3 | EBI-2342111, EBI-913954 | |
BINARY | Q9C019 | YJU2 Q9BW85 | 3 | EBI-2342111, EBI-10300345 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 16-61 | RING-type | ||||
Sequence: CTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQ | ||||||
Zinc finger | 78-119 | B box-type | ||||
Sequence: LGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFL | ||||||
Coiled coil | 126-229 | |||||
Sequence: YRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQ | ||||||
Domain | 276-465 | B30.2/SPRY | ||||
Sequence: EMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG |
Sequence similarities
Belongs to the TRIM/RBCC family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9C019-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsAlpha
- Length465
- Mass (Da)52,113
- Last updated2001-06-01 v1
- Checksum303B8BF8623CB00A
Q9C019-2
- Name2
- SynonymsBeta
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0Y5R0 | H0Y5R0_HUMAN | TRIM15 | 164 | ||
A0A087X199 | A0A087X199_HUMAN | TRIM15 | 396 | ||
A0A0G2JJP1 | A0A0G2JJP1_HUMAN | TRIM15 | 465 | ||
A0A0G2JL27 | A0A0G2JL27_HUMAN | TRIM15 | 396 |
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF220132 EMBL· GenBank· DDBJ | AAG53505.1 EMBL· GenBank· DDBJ | mRNA | ||
AF220133 EMBL· GenBank· DDBJ | AAG53506.1 EMBL· GenBank· DDBJ | mRNA | ||
U34249 EMBL· GenBank· DDBJ | AAD03787.1 EMBL· GenBank· DDBJ | mRNA | ||
BA000025 EMBL· GenBank· DDBJ | BAB63331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB088089 EMBL· GenBank· DDBJ | BAC54922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX248419 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX005441 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR759838 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC038585 EMBL· GenBank· DDBJ | AAH38585.1 EMBL· GenBank· DDBJ | mRNA |