Q9BYV6 · TRI55_HUMAN
- ProteinTripartite motif-containing protein 55
- GeneTRIM55
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids548 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (By similarity).
Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (PubMed:36737649).
Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (PubMed:36737649).
Catalytic activity
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | microtubule | |
Cellular Component | nucleus | |
Molecular Function | identical protein binding | |
Molecular Function | protein-macromolecule adaptor activity | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | diapedesis | |
Biological Process | leukocyte migration involved in inflammatory response | |
Biological Process | macrophage migration | |
Biological Process | positive regulation of non-canonical NF-kappaB signal transduction | |
Biological Process | protein K48-linked ubiquitination | |
Biological Process | protein ubiquitination | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTripartite motif-containing protein 55
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BYV6
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_074078 | 50 | rare variant; found in a patient with hypertrophic cardiomyopathy; uncertain significance | |||
Sequence: C → Y | ||||||
Natural variant | VAR_074079 | 54 | in dbSNP:rs1320007526 | |||
Sequence: I → V | ||||||
Natural variant | VAR_074080 | 79 | rare variant; found in a patient with hypertrophic cardiomyopathy; uncertain significance; dbSNP:rs769797275 | |||
Sequence: P → A | ||||||
Natural variant | VAR_074081 | 241 | rare variant; found in a patient with hypertrophic cardiomyopathy; uncertain significance | |||
Sequence: L → M | ||||||
Natural variant | VAR_074082 | 252 | ||||
Sequence: S → F | ||||||
Natural variant | VAR_074083 | 257 | in dbSNP:rs61741078 | |||
Sequence: N → K | ||||||
Natural variant | VAR_074084 | 258 | in dbSNP:rs1279027783 | |||
Sequence: V → I | ||||||
Natural variant | VAR_074085 | 336 | in dbSNP:rs770907206 | |||
Sequence: E → Q | ||||||
Natural variant | VAR_052144 | 343 | in dbSNP:rs7843605 | |||
Sequence: K → R | ||||||
Natural variant | VAR_074086 | 392 | rare variant; found in a patient with hypertrophic cardiomyopathy; uncertain significance; dbSNP:rs200545859 | |||
Sequence: P → T | ||||||
Natural variant | VAR_074087 | 418 | ||||
Sequence: T → I | ||||||
Natural variant | VAR_074088 | 452 | rare variant; found in a patient with hypertrophic cardiomyopathy; uncertain significance; dbSNP:rs755876598 | |||
Sequence: K → N | ||||||
Natural variant | VAR_074089 | 458 | ||||
Sequence: P → L | ||||||
Natural variant | VAR_074090 | 488 | in dbSNP:rs770146015 | |||
Sequence: A → T | ||||||
Natural variant | VAR_074091 | 506 | rare variant; found in a patient with hypertrophic cardiomyopathy; uncertain significance; dbSNP:rs781152511 | |||
Sequence: T → S | ||||||
Natural variant | VAR_082913 | 523 | In isoform Q9BYV6-3; | |||
Sequence: H → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 727 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000056286 | 1-548 | Tripartite motif-containing protein 55 | |||
Sequence: MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQGEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE |
Post-translational modification
Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3.
Proteomic databases
PTM databases
Interaction
Subunit
Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9BYV6 | TRIM23 P36406 | 2 | EBI-2341179, EBI-740098 | |
BINARY | Q9BYV6 | TRIM55 Q9BYV6 | 2 | EBI-2341179, EBI-2341179 | |
BINARY | Q9BYV6 | USP13 Q92995 | 2 | EBI-2341179, EBI-714351 | |
BINARY | Q9BYV6-2 | BYSL Q13895 | 3 | EBI-11522718, EBI-358049 | |
BINARY | Q9BYV6-2 | RAD23A P54725 | 3 | EBI-11522718, EBI-746453 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 10-66 | RING-type | ||||
Sequence: FSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRG | ||||||
Zinc finger | 103-145 | B box-type | ||||
Sequence: NIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCS | ||||||
Coiled coil | 168-248 | |||||
Sequence: QKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALI | ||||||
Domain | 269-327 | COS | ||||
Sequence: MDEPEMAVFLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFY | ||||||
Region | 326-532 | Disordered | ||||
Sequence: FYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQGEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQIGFEAPPLQGQAAAPASGSGADSE | ||||||
Compositional bias | 327-343 | Acidic residues | ||||
Sequence: YREDEDEEEEEGGEGEK | ||||||
Compositional bias | 351-367 | Acidic residues | ||||
Sequence: GEAVEVEEVENVQTEFP | ||||||
Compositional bias | 392-406 | Pro residues | ||||
Sequence: PVSSPEPPPALPPAA | ||||||
Compositional bias | 415-430 | Polar residues | ||||
Sequence: VVPTGSEQTTESETPV | ||||||
Compositional bias | 448-462 | Polar residues | ||||
Sequence: GQTRKATTNPPCTPG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q9BYV6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Synonymsp60
- Length548
- Mass (Da)60,466
- Last updated2005-10-25 v2
- Checksum2AA2E4D4F5C3E3A1
Q9BYV6-2
- Name2
- Synonymsp50
- Differences from canonical
- 412-507: Missing
Q9BYV6-3
- Name3
- Synonymsp60B
- Differences from canonical
- 509-548: IGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE → ELVICLALLAFLILHYIWSQIQCLIFTLMDWI
Q9BYV6-4
- Name4
- Synonymsp27
- Differences from canonical
- 202-508: Missing
Sequence caution
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 102 | in Ref. 2; CAC43019/CAC43020 | ||||
Sequence: E → G | ||||||
Alternative sequence | VSP_015996 | 202-508 | in isoform 4 | |||
Sequence: Missing | ||||||
Compositional bias | 327-343 | Acidic residues | ||||
Sequence: YREDEDEEEEEGGEGEK | ||||||
Sequence conflict | 345 | in Ref. 2; CAC43019/CAC43020/CAD24432 | ||||
Sequence: G → E | ||||||
Compositional bias | 351-367 | Acidic residues | ||||
Sequence: GEAVEVEEVENVQTEFP | ||||||
Compositional bias | 392-406 | Pro residues | ||||
Sequence: PVSSPEPPPALPPAA | ||||||
Alternative sequence | VSP_015997 | 412-507 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 415-430 | Polar residues | ||||
Sequence: VVPTGSEQTTESETPV | ||||||
Compositional bias | 448-462 | Polar residues | ||||
Sequence: GQTRKATTNPPCTPG | ||||||
Alternative sequence | VSP_015998 | 509-548 | in isoform 3 | |||
Sequence: IGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE → ELVICLALLAFLILHYIWSQIQCLIFTLMDWI |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ291712 EMBL· GenBank· DDBJ | CAC32839.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AJ291712 EMBL· GenBank· DDBJ | CAC32840.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AJ243488 EMBL· GenBank· DDBJ | CAC43019.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ243489 EMBL· GenBank· DDBJ | CAC43020.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ277493 EMBL· GenBank· DDBJ | CAC81835.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ431704 EMBL· GenBank· DDBJ | CAD24432.1 EMBL· GenBank· DDBJ | mRNA | ||
AK091310 EMBL· GenBank· DDBJ | BAG52332.1 EMBL· GenBank· DDBJ | mRNA | ||
AK091728 EMBL· GenBank· DDBJ | BAG52405.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471068 EMBL· GenBank· DDBJ | EAW86894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471068 EMBL· GenBank· DDBJ | EAW86895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC007750 EMBL· GenBank· DDBJ | AAH07750.2 EMBL· GenBank· DDBJ | mRNA | ||
BT007212 EMBL· GenBank· DDBJ | AAP35876.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |