Q9BY07 · S4A5_HUMAN

  • Protein
    Electrogenic sodium bicarbonate cotransporter 4
  • Gene
    SLC4A5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3.

Catalytic activity

Activity regulation

Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

Isoform 3

Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

Isoform 8

Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionmonoatomic anion transmembrane transporter activity
Molecular Functionsodium:bicarbonate symporter activity
Molecular Functionsolute:inorganic anion antiporter activity
Biological Processbicarbonate transport
Biological Processcerebrospinal fluid secretion
Biological Processepithelial cell development
Biological Processmitochondrion distribution
Biological Processregulation of gene expression
Biological Processregulation of intracellular pH
Biological Processregulation of systemic arterial blood pressure
Biological Processrenal system process
Biological Processretina development in camera-type eye
Biological Processtransmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Electrogenic sodium bicarbonate cotransporter 4
  • Alternative names
    • NBCe2
    • Solute carrier family 4 member 5

Gene names

    • Name
      SLC4A5
    • Synonyms
      NBC4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BY07
  • Secondary accessions
    • Q32MA7
    • Q59EQ9
    • Q8WXD3
    • Q8WXD7
    • Q96DS7

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein
Note: Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-521Cytoplasmic
Transmembrane522-544Helical
Topological domain545-555Extracellular
Transmembrane556-587Helical
Topological domain588-606Cytoplasmic
Transmembrane607-628Helical
Topological domain629-742Extracellular
Transmembrane743-762Helical
Topological domain763-773Cytoplasmic
Transmembrane774-795Helical
Topological domain796-828Extracellular
Transmembrane829-847Helical
Topological domain848-866Cytoplasmic
Transmembrane867-883Helical
Topological domain884-888Extracellular
Transmembrane889-908Helical
Topological domain909-928Cytoplasmic
Transmembrane929-948Helical
Topological domain949-953Extracellular
Transmembrane954-971Helical
Topological domain972-1016Cytoplasmic
Transmembrane1017-1034Helical
Topological domain1035-1039Extracellular
Transmembrane1040-1057Helical
Topological domain1058-1137Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_048350251in dbSNP:rs17009792
Natural variantVAR_061032253in dbSNP:rs55651232

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,377 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003289201-1137Electrogenic sodium bicarbonate cotransporter 4

Proteomic databases

PTM databases

Expression

Tissue specificity

Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.

Isoform 3

Expressed in the brain, heart, kidney, testis, pancreas, muscle and peripheral blood leukocytes.

Gene expression databases

Organism-specific databases

    • ENSG00000188687Group enriched (choroid plexus, parathyroid gland, retina, testis, thyroid gland)

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-27Basic and acidic residues
Region1-52Disordered
Region64-94Disordered
Compositional bias68-94Polar residues
Region221-255Disordered
Compositional bias231-245Polar residues
Region438-478Disordered
Compositional bias1079-1099Basic and acidic residues
Region1079-1137Disordered
Compositional bias1112-1137Polar residues

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (8)
  • Sequence status
    Complete

This entry describes 8 isoforms produced by Alternative splicing.

Q9BY07-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    NBC4a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,137
  • Mass (Da)
    126,255
  • Last updated
    2008-04-08 v2
  • Checksum
    ED4E4A4DC2CA17F1
MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL

Q9BY07-2

  • Name
    2
  • Synonyms
    NBC4b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9BY07-3

  • Name
    3
  • Synonyms
    NBC4c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9BY07-4

  • Name
    4
  • Synonyms
    NBC4d
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9BY07-5

  • Name
    5
  • Synonyms
    isoform d variant
  • Note
    Incomplete sequence.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 88-91: SRTR → EHKG
    • 866-993: KAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERC → GTESNRHHRLHPDGNLCLPGSHPKVYPPAGAVRSLPLHGRGLPEWHPVLGTLQALPDASQAPAGPCLPAARAAAPDPPLHPGADPLPGGALDPQIHGGCHHLPGHDPGPHHRSKASGFHLFPARPGLD
    • 994-1137: Missing

Q9BY07-6

Q9BY07-7

  • Name
    7
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 27-91: ECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTR → G
    • 774-811: Missing
    • 973-988: Missing

Q9BY07-8

  • Name
    8
  • Synonyms
    NBC4e
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E7EQT3E7EQT3_HUMANSLC4A5998
C9JU12C9JU12_HUMANSLC4A5144
C9JW32C9JW32_HUMANSLC4A5129
C9JNL6C9JNL6_HUMANSLC4A5122
A0A1B0GUV9A0A1B0GUV9_HUMANSLC4A571
A0A1B0GVY3A0A1B0GVY3_HUMANSLC4A5210

Sequence caution

The sequence AAG18492.1 differs from that shown. Reason: Frameshift
The sequence AAL50802.1 differs from that shown. Reason: Frameshift
The sequence EAW99691.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-27Basic and acidic residues
Alternative sequenceVSP_05277027-91in isoform 7
Compositional bias68-94Polar residues
Alternative sequenceVSP_05277188-91in isoform 5
Compositional bias231-245Polar residues
Sequence conflict612in Ref. 6; AAL48291/AAL50802
Sequence conflict699in Ref. 6; AAL48291
Sequence conflict759in Ref. 6; AAL50802
Alternative sequenceVSP_052772774-811in isoform 6 and isoform 7
Sequence conflict813in Ref. 2; AAK26741
Alternative sequenceVSP_052774866-924in isoform 6
Alternative sequenceVSP_052773866-993in isoform 5
Sequence conflict896in Ref. 6; AAL48291
Sequence conflict923in Ref. 6; AAL48291
Alternative sequenceVSP_052775950-1046in isoform 4
Alternative sequenceVSP_052776973-988in isoform 3, isoform 6 and isoform 7
Alternative sequenceVSP_052777994-1137in isoform 5
Alternative sequenceVSP_0527781046in isoform 2 and isoform 6
Alternative sequenceVSP_0527791068-1137in isoform 8
Alternative sequenceVSP_0527801071-1075in isoform 6
Alternative sequenceVSP_0527811076-1137in isoform 6
Compositional bias1079-1099Basic and acidic residues
Compositional bias1112-1137Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF207661
EMBL· GenBank· DDBJ
AAG18492.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AF243499
EMBL· GenBank· DDBJ
AAK26741.1
EMBL· GenBank· DDBJ
mRNA
AF293338
EMBL· GenBank· DDBJ
AAK97073.1
EMBL· GenBank· DDBJ
mRNA
AF293337
EMBL· GenBank· DDBJ
AAK97072.1
EMBL· GenBank· DDBJ
mRNA
AF452248
EMBL· GenBank· DDBJ
AAL48291.1
EMBL· GenBank· DDBJ
mRNA
AF453528
EMBL· GenBank· DDBJ
AAL50802.1
EMBL· GenBank· DDBJ
mRNA Frameshift
CH471053
EMBL· GenBank· DDBJ
EAW99690.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471053
EMBL· GenBank· DDBJ
EAW99691.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
CH471053
EMBL· GenBank· DDBJ
EAW99693.1
EMBL· GenBank· DDBJ
Genomic DNA
BC109221
EMBL· GenBank· DDBJ
AAI09222.1
EMBL· GenBank· DDBJ
mRNA
AB209752
EMBL· GenBank· DDBJ
BAD92989.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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