Q9BXU9 · CABP8_HUMAN
- ProteinCalcium-binding protein 8
- GeneCALN1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids261 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 91 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 93 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 95 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 102 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 127 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 129 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 131 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 133 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 138 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | trans-Golgi network membrane | |
Molecular Function | calcium ion binding |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-binding protein 8
- Short namesCaBP8
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BXU9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein
Cell membrane ; Single-pass type IV membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-234 | Cytoplasmic | ||||
Sequence: MRLPEQPGEGKPENEKKGDGGALGGGEEPPRSQAPDFPTWEKMPFHHVTAGLLYKGNYLNRSLSAGSDSEQLANISVEELDEIREAFRVLDRDGNGFISKQELGMAMRSLGYMPSEVELAIIMQRLDMDGDGQVDFDEFMTILGPKLVSSEGRDGFLGNTIDSIFWQFDMQRITLEELKHILYHAFRDHLTMKDIENIIINEEESLNETSGNCQTEFEGVHSQKQNRQTCVRKS | ||||||
Transmembrane | 235-255 | Helical; Anchor for type IV membrane protein | ||||
Sequence: LICAFAMAFIISVMLIAANQI | ||||||
Topological domain | 256-261 | Extracellular | ||||
Sequence: LRSGME |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 263 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000073529 | 1-261 | Calcium-binding protein 8 | |||
Sequence: MRLPEQPGEGKPENEKKGDGGALGGGEEPPRSQAPDFPTWEKMPFHHVTAGLLYKGNYLNRSLSAGSDSEQLANISVEELDEIREAFRVLDRDGNGFISKQELGMAMRSLGYMPSEVELAIIMQRLDMDGDGQVDFDEFMTILGPKLVSSEGRDGFLGNTIDSIFWQFDMQRITLEELKHILYHAFRDHLTMKDIENIIINEEESLNETSGNCQTEFEGVHSQKQNRQTCVRKSLICAFAMAFIISVMLIAANQILRSGME |
Proteomic databases
PTM databases
Expression
Tissue specificity
Brain specific.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9BXU9 | DNAJC30 Q96LL9 | 3 | EBI-12187137, EBI-8639143 | |
BINARY | Q9BXU9 | FATE1 Q969F0 | 3 | EBI-12187137, EBI-743099 | |
BINARY | Q9BXU9 | LIME1 Q9H400 | 3 | EBI-12187137, EBI-2830566 | |
BINARY | Q9BXU9 | MAL P21145 | 3 | EBI-12187137, EBI-3932027 | |
BINARY | Q9BXU9 | PLP1 P60201-2 | 3 | EBI-12187137, EBI-12188331 | |
BINARY | Q9BXU9 | SEC22A Q96IW7 | 3 | EBI-12187137, EBI-8652744 | |
BINARY | Q9BXU9 | SLPI P03973 | 3 | EBI-12187137, EBI-355293 | |
BINARY | Q9BXU9 | USE1 Q9NZ43 | 3 | EBI-12187137, EBI-742842 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-22 | Basic and acidic residues | ||||
Sequence: MRLPEQPGEGKPENEKKGDGGA | ||||||
Region | 1-39 | Disordered | ||||
Sequence: MRLPEQPGEGKPENEKKGDGGALGGGEEPPRSQAPDFPT | ||||||
Domain | 78-113 | EF-hand 1 | ||||
Sequence: EELDEIREAFRVLDRDGNGFISKQELGMAMRSLGYM | ||||||
Domain | 114-149 | EF-hand 2 | ||||
Sequence: PSEVELAIIMQRLDMDGDGQVDFDEFMTILGPKLVS |
Domain
The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9BXU9-2
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length261
- Mass (Da)29,324
- Last updated2021-02-10 v2
- Checksum8276320AD714FACD
Q9BXU9-1
- Name2
- Differences from canonical
- 1-42: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9PFU3 | E9PFU3_HUMAN | CALN1 | 125 |
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-22 | Basic and acidic residues | ||||
Sequence: MRLPEQPGEGKPENEKKGDGGA | ||||||
Alternative sequence | VSP_060873 | 1-42 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF282250 EMBL· GenBank· DDBJ | AAK15155.1 EMBL· GenBank· DDBJ | mRNA | ||
AY007302 EMBL· GenBank· DDBJ | AAG09620.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC020200 EMBL· GenBank· DDBJ | AAH20200.1 EMBL· GenBank· DDBJ | mRNA | ||
AC004845 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC004905 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005011 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC006334 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC067941 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092424 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092785 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471140 EMBL· GenBank· DDBJ | EAX07902.1 EMBL· GenBank· DDBJ | Genomic DNA |