INVOLVEMENT IN SPGFX6, VARIANTS SPGFX6 SER-799 AND GLY-825, CHARACTERIZATION OF VARIANTS SPGFX6 SER-799 AND GLY-825, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY
The interaction between USP26 and Mdm2 and the subsequent deubiquitination of Mdm2 serves most probably to regulate Mdm2. Future therapeutic modalities that interfere with the association between USP26 and Mdm2 will be used to destabilize the ligase in malignancies where it is upregulated.
identification in a normozoospermic man of a nonsense mutation (c.882C>A) which causes the production of a truncated protein suggests a marginal role of USP26 in male spermatogenesis
there is a significant difference in USP26 gene expression between the obstructive azoospermia complete maturation arrest samples and Sertoli Cell-Only Syndrome samples
The nucleotide polymorphisms of the Usp26 gene might be closely related with idiopathic male infertility and exert a negative effect on the testis function.
results indicated the variation of USP26 was not directly associated with human sperm count but suggested it might be a potential role in sperm motility
Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan; Observational study of gene-disease association. (HuGE Navigator)
Observational study of gene-disease association. (HuGE Navigator); The USP26 gene might be of importance in male reproduction. Mutations in this gene might be associated with male infertility and might negatively affect testicular function.
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