Q9BXT5 · TEX15_HUMAN
- ProteinTestis-expressed protein 15
- GeneTEX15
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2789 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By similarity).
Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity).
PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity).
Not required for piRNA biosynthesis (By similarity).
Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity).
PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity).
Not required for piRNA biosynthesis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | cell differentiation | |
Biological Process | DNA methylation-dependent heterochromatin formation | |
Biological Process | DNA repair | |
Biological Process | male meiotic nuclear division | |
Biological Process | regulation of double-strand break repair via homologous recombination | |
Biological Process | regulatory ncRNA-mediated gene silencing | |
Biological Process | retrotransposon silencing | |
Biological Process | spermatogenesis | |
Biological Process | synaptonemal complex assembly |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTestis-expressed protein 15
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BXT5
Proteomes
Organism-specific databases
Disease & Variants
Involvement in disease
Spermatogenic failure 25 (SPGF25)
- Note
- DescriptionAn autosomal recessive infertility disorder caused by spermatogenesis defects that result in severe oligozoospermia or azoospermia.
- See alsoMIM:617960
Natural variants in SPGF25
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_080904 | 710-2789 | missing | in SPGF25; dbSNP:rs864309485 | |
VAR_080905 | 807-2789 | missing | in SPGF25 | |
VAR_080906 | 2312-2789 | missing | in SPGF25; uncertain significance; dbSNP:rs763654373 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_060394 | 104 | in dbSNP:rs323347 | |||
Sequence: C → R | ||||||
Natural variant | VAR_060395 | 383 | in dbSNP:rs9297162 | |||
Sequence: P → L | ||||||
Natural variant | VAR_080904 | 710-2789 | in SPGF25; dbSNP:rs864309485 | |||
Sequence: Missing | ||||||
Natural variant | VAR_080905 | 807-2789 | in SPGF25 | |||
Sequence: Missing | ||||||
Natural variant | VAR_060396 | 1035 | in dbSNP:rs323346 | |||
Sequence: I → V | ||||||
Natural variant | VAR_060397 | 1311 | in dbSNP:rs323345 | |||
Sequence: N → S | ||||||
Natural variant | VAR_060398 | 1337 | in dbSNP:rs323344 | |||
Sequence: L → V | ||||||
Natural variant | VAR_060399 | 1439 | in dbSNP:rs323343 | |||
Sequence: K → R | ||||||
Natural variant | VAR_061711 | 2138 | in dbSNP:rs60474250 | |||
Sequence: D → N | ||||||
Natural variant | VAR_080906 | 2312-2789 | in SPGF25; uncertain significance; dbSNP:rs763654373 | |||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3,803 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000244483 | 1-2789 | Testis-expressed protein 15 | |||
Sequence: MPSDAKDSVNGDLLLNWTSLKNILSGLNASFPLHNNTGSSTVTTSKSIKDPRLMRREESMGEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEVVPGDCAVLTNGLDTPCFKTSVNDSQSWAHNMGSEDYDCIPPNKVTMAGQCKDQGNFSFPISVSNVVSEVENQNHSEEKAQRAQQESGNAYTKEYSSHIFQDSQSSDLKTIYQTGCQTSTVFPLKKKVSIDEYLQNTGKMKNFADLEDSSKHEEKQTSWKEIDNDFTNETKISPIDNYIVLHQEYKESESHNSFGKSCDKILITQELEITKSSTSTIKDKDELDHLALEWQITPSFESLSQKHPQHSVEYEGNIHTSLAIAQKLMELKLGKINQNYASIITEAFPKPKDIPQAKEMFIDTVISSYNIETAHDSSNCSITREHICVHRKNENEPVSLENIQRDYKETAYVEDRGQDHNLFCNSQLSNDIWLNVNFKKQTDRENQNEAKENSASCVENNIENIYGDKKQDSHTNENFSNIDEKEDKNYHNIEILSSEEFSTKFNLICREDNAVSAATALLESEEDTISAVKQKDTENTGRSVEHLASTTFPKTASSSVCVASNAAIQIASATMPALSLNNDDHQIYQFKETCSSESPDFGLLVKHRVSDCEIDTDKNKSQESFHQSINENLVLQSIELESEIEIELEDCDDAFIFQQDTHSHENMLCEEFVTSYKALKSRISWEGLLALDNGEMEVLESTTGRENSDQHYSKESNYFYSSTQNNETELTSPILLPDLQIKITNIFRPGFSPTADSLALKDSFCTHVTEATKPEINKEDGEILGFDIYSQPFGENADYPCEDKVDNIRQESGPVSNSEISLSFDLSRNTDVNHTSENQNSESLFTEPSNVTTIDDGSRCFFTKSKTDYNDTKNKKEVESRISKRKLHISSRDQNIPHKDLRRHKIYGRKRRLTSQDSSECFSSLSQGRIKTFSQSEKHIKSVLNILSDEASLCKSKCLSRKLDKAVVHLKKAHRRVHTSLQLITKVGEERKGPLPKSYAIICNNFWESCDLQGYSSVSQRKYYSTKHFSSKRKYDKRRKKRAPKADISKSLTHVSKHKSYKTSGEKKCLSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQPFSGKTAYLFSPDHSDEKLIEKENQIDTAFLSSTSKYEKLEKHSANHNVKDATKENSCDANEVINESNSVSLSCIKENINSSTGNDCDATCIGHTKAKTDVLISVLDSNVKHFLNDLYQQGNLILSDCKRNLEVKWTDPIERPKQNIITGNFLMGPLNLTLIASKKYSIPQLSAAAVTDSEGESSKSYLDKQRILTVDSFAASSTVPHCEQSCREKELLKTEQCSSGNCLHTDGNETNVTENYELDVASGTEEDKSYGENIVELSSSDSSLLLKDNVKGSSSETCIVKKDTEDRITWKVKQAEKAKDSVYKRSMTEGSTVNTEYKNQKNQISEESCLNEKIITTNLIDSHLSTKNTTTESVPLKNTVSNPLNKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIANLSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMMMETIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELLEETKREKNSYYVFLKYKRQVNECEAIMEHCSDCFDFSLSVPFTCGVNFGDSLEDLEILRKSTLKLINVCGDSPKVHSYPGKQDHLWIIIEMISSKVNFIKNNEAVRVKISLYGLEHIFFDAAKNLVWKERTQSFSKKYSQKKDEERLLRVNKCAFSKLQKIYDTLSKDLNNEPISPIGLEEDTIIASRKSDHPINEATISIENSKFNSNLLAHPDICCISEILDQAEFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENVLDVVINHSHEAIILKPEAIEMYIEIVMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELVQCQEKMASFSFLKDNSTDVCLWKVIETAVSELKKDLDIICKYNEAVNCSYAIHLLSRELQELSEIKKLLKKSKYFISTYIDFVPYIASINYGSTVTELEYNYNQFSTLLKNVMSAPRKDLGKMAHIRKVMKTIEHMKMICTKNAELTISFFLCQMLYNRRKILQLKRKEKMNIHIVKPGENNNKFSISTMLPPVSECINKNISNSSKKRPSTVDKCEDSQEQQQDTTVSSCKKLKVDMKDVTKINREKATFKHPRTTGSHPKSENKIVPSSCDSLKRNHLTPKKVEMQRSLPGSLLPLENPKDTCASKSESKIDLTVSSDHFSGQQENLNSMKKRNVNFSAAETKSDKKDCAAFAICDQKSVHGTFSPDHGTLLQKFLKNSPDPTQKSCLSDINPETDVSLVPDASVLSKPIFCFVKDVHPDLEMNDTVFELQDNDIVNSSIKNSSCMTSPEPICIQNKIPTLQINKLQPTETESEDKYMKDTLNPNTVHTFGASGHITLNVNQGAEYSLSEQQNDKNSKVLMQNAATYWNELPQSACNPTYNSSEHLFGTSYPYSAWCVYQYSNSNGNAITQTYQGITSYEVQPSPSGLLTTVASTAQGTHSNLLYSQYFTYFAGEPQANGFVPVNGYFQSQIPASNFRQPIFSQYASHQPLPQATYPYLPNRFVPPEVPWVYAPWHQESFHPGH |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-48 | Polar residues | ||||
Sequence: HNNTGSSTVTTSKSI | ||||||
Region | 34-99 | Disordered | ||||
Sequence: HNNTGSSTVTTSKSIKDPRLMRREESMGEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEV | ||||||
Compositional bias | 60-99 | Polar residues | ||||
Sequence: MGEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEV | ||||||
Region | 169-191 | Disordered | ||||
Sequence: ENQNHSEEKAQRAQQESGNAYTK | ||||||
Compositional bias | 1063-1079 | Basic residues | ||||
Sequence: FSSKRKYDKRRKKRAPK | ||||||
Region | 1063-1166 | Disordered | ||||
Sequence: FSSKRKYDKRRKKRAPKADISKSLTHVSKHKSYKTSGEKKCLSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQP | ||||||
Compositional bias | 1080-1103 | Basic and acidic residues | ||||
Sequence: ADISKSLTHVSKHKSYKTSGEKKC | ||||||
Compositional bias | 1104-1166 | Polar residues | ||||
Sequence: LSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQP | ||||||
Region | 2303-2331 | Disordered | ||||
Sequence: KNISNSSKKRPSTVDKCEDSQEQQQDTTV | ||||||
Region | 2351-2379 | Disordered | ||||
Sequence: KATFKHPRTTGSHPKSENKIVPSSCDSLK | ||||||
Compositional bias | 2364-2379 | Polar residues | ||||
Sequence: PKSENKIVPSSCDSLK |
Sequence similarities
Belongs to the TEX15 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,789
- Mass (Da)315,336
- Last updated2010-10-05 v2
- Checksum1065EDD045C67BF6
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y358 | A0A2R8Y358_HUMAN | TEX15 | 3172 | ||
A0A1W2PS94 | A0A1W2PS94_HUMAN | TEX15 | 3176 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-48 | Polar residues | ||||
Sequence: HNNTGSSTVTTSKSI | ||||||
Compositional bias | 60-99 | Polar residues | ||||
Sequence: MGEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEV | ||||||
Compositional bias | 1063-1079 | Basic residues | ||||
Sequence: FSSKRKYDKRRKKRAPK | ||||||
Compositional bias | 1080-1103 | Basic and acidic residues | ||||
Sequence: ADISKSLTHVSKHKSYKTSGEKKC | ||||||
Compositional bias | 1104-1166 | Polar residues | ||||
Sequence: LSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQP | ||||||
Compositional bias | 2364-2379 | Polar residues | ||||
Sequence: PKSENKIVPSSCDSLK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF285605 EMBL· GenBank· DDBJ | AAK31984.1 EMBL· GenBank· DDBJ | mRNA | ||
AC009314 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC090281 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |