Q9BXJ4 · C1QT3_HUMAN

  • Protein
    Complement C1q tumor necrosis factor-related protein 3
  • Gene
    C1QTNF3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen trimer
Cellular Componentextracellular exosome
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functionidentical protein binding
Biological Processfat cell differentiation
Biological Processintracellular triglyceride homeostasis
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of gluconeogenesis
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of monocyte chemotactic protein-1 production
Biological Processnegative regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of adiponectin secretion
Biological Processpositive regulation of cytokine production

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Complement C1q tumor necrosis factor-related protein 3
  • Alternative names
    • Collagenous repeat-containing sequence 26 kDa protein (CORS26)
    • Secretory protein CORS26

Gene names

    • Name
      C1QTNF3
    • Synonyms
      CTRP3
    • ORF names
      UNQ753/PRO1484

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BXJ4
  • Secondary accessions
    • Q0VAN4
    • Q542Y2
    • Q6MZN1
    • Q96KY1

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 282 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_000000353123-246
Glycosylation70In isoform Q9BXJ4-3; N-linked (GlcNAc...) asparagine

Post-translational modification

Isoform 3

Glycosylated on Asn-70.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in colon and small intestine.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9BXJ4COLGALT2 Q8IYK42EBI-10697546, EBI-10263496
BINARY Q9BXJ4HTT P428583EBI-10697546, EBI-466029

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain51-113Collagen-like
Region53-110Disordered
Compositional bias81-104Basic and acidic residues
Domain113-246C1q

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q9BXJ4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    246
  • Mass (Da)
    26,994
  • Last updated
    2001-06-01 v1
  • Checksum
    C589B6C3A73E5D29
MLWRQLIYWQLLALFFLPFCLCQDEYMESPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

Q9BXJ4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9BXJ4-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 28-28: E → EVSGRTNKVVARIVQSHQQTGRSGSRREKVRERSHPKTGTVDNNTSTDLKSLRPDELPHPEVDDLAQITTFWGQ

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04315728in isoform 3
Alternative sequenceVSP_01162446-69in isoform 2
Compositional bias81-104Basic and acidic residues
Alternative sequenceVSP_01162582-105in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF329837
EMBL· GenBank· DDBJ
AAK17961.1
EMBL· GenBank· DDBJ
mRNA
AF326976
EMBL· GenBank· DDBJ
AAK70344.1
EMBL· GenBank· DDBJ
mRNA
EU399231
EMBL· GenBank· DDBJ
ABY86416.1
EMBL· GenBank· DDBJ
mRNA
EU399232
EMBL· GenBank· DDBJ
ABY86417.1
EMBL· GenBank· DDBJ
mRNA
AY358388
EMBL· GenBank· DDBJ
AAQ88754.1
EMBL· GenBank· DDBJ
mRNA
AK295968
EMBL· GenBank· DDBJ
BAG58744.1
EMBL· GenBank· DDBJ
mRNA
AK315921
EMBL· GenBank· DDBJ
BAH14292.1
EMBL· GenBank· DDBJ
mRNA
AK075533
EMBL· GenBank· DDBJ
BAC11676.1
EMBL· GenBank· DDBJ
mRNA
BX640995
EMBL· GenBank· DDBJ
CAE45998.1
EMBL· GenBank· DDBJ
mRNA
AC139783
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC139792
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471118
EMBL· GenBank· DDBJ
EAX10820.1
EMBL· GenBank· DDBJ
Genomic DNA
BC112925
EMBL· GenBank· DDBJ
AAI12926.1
EMBL· GenBank· DDBJ
mRNA
BC120990
EMBL· GenBank· DDBJ
AAI20991.1
EMBL· GenBank· DDBJ
mRNA
AF173888
EMBL· GenBank· DDBJ
AAQ13635.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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