Q9BXC0 · HCAR1_HUMAN
- ProteinHydroxycarboxylic acid receptor 1
- GeneHCAR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids346 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | negative regulation of lipid catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHydroxycarboxylic acid receptor 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BXC0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-21 | Extracellular | ||||
Sequence: MYNGSCCRIEGDTISQVMPPL | ||||||
Transmembrane | 22-42 | Helical; Name=1 | ||||
Sequence: LIVAFVLGALGNGVALCGFCF | ||||||
Topological domain | 43-49 | Cytoplasmic | ||||
Sequence: HMKTWKP | ||||||
Transmembrane | 50-70 | Helical; Name=2 | ||||
Sequence: STVYLFNLAVADFLLMICLPF | ||||||
Topological domain | 71-89 | Extracellular | ||||
Sequence: RTDYYLRRRHWAFGDIPCR | ||||||
Transmembrane | 90-110 | Helical; Name=3 | ||||
Sequence: VGLFTLAMNRAGSIVFLTVVA | ||||||
Topological domain | 111-130 | Cytoplasmic | ||||
Sequence: ADRYFKVVHPHHAVNTISTR | ||||||
Transmembrane | 131-151 | Helical; Name=4 | ||||
Sequence: VAAGIVCTLWALVILGTVYLL | ||||||
Topological domain | 152-182 | Extracellular | ||||
Sequence: LENHLCVQETAVSCESFIMESANGWHDIMFQ | ||||||
Transmembrane | 183-203 | Helical; Name=5 | ||||
Sequence: LEFFMPLGIILFCSFKIVWSL | ||||||
Topological domain | 204-220 | Cytoplasmic | ||||
Sequence: RRRQQLARQARMKKATR | ||||||
Transmembrane | 221-241 | Helical; Name=6 | ||||
Sequence: FIMVVAIVFITCYLPSVSARL | ||||||
Topological domain | 242-261 | Extracellular | ||||
Sequence: YFLWTVPSSACDPSVHGALH | ||||||
Transmembrane | 262-281 | Helical; Name=7 | ||||
Sequence: ITLSFTYMNSMLDPLVYYFS | ||||||
Topological domain | 282-346 | Cytoplasmic | ||||
Sequence: SPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_025151 | 43 | in dbSNP:rs35292336 | |||
Sequence: H → Q | ||||||
Mutagenesis | 99 | Diminishes the response to L-lactate. | ||||
Sequence: R → A | ||||||
Mutagenesis | 233 | Diminishes the response to L-lactate. | ||||
Sequence: Y → A | ||||||
Mutagenesis | 240 | Diminishes the response to L-lactate. | ||||
Sequence: R → A | ||||||
Natural variant | VAR_025152 | 253 | ||||
Sequence: D → E | ||||||
Natural variant | VAR_061218 | 253 | in dbSNP:rs36124671 | |||
Sequence: D → H | ||||||
Mutagenesis | 267 | Diminishes the response to L-lactate. | ||||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 461 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069586 | 1-346 | Hydroxycarboxylic acid receptor 1 | |||
Sequence: MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH | ||||||
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 88↔165 | |||||
Sequence: CRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.
Gene expression databases
Organism-specific databases
Structure
Sequence
- Sequence statusComplete
- Length346
- Mass (Da)39,295
- Last updated2001-06-01 v1
- ChecksumE0DB114EEB3A47A5
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 38 | in Ref. 11; AAH95506 | ||||
Sequence: C → Y | ||||||
Sequence conflict | 113 | in Ref. 11; AAH66883 | ||||
Sequence: R → K | ||||||
Sequence conflict | 187 | in Ref. 11; AAH95506 | ||||
Sequence: M → I | ||||||
Sequence conflict | 213 | in Ref. 11; AAH95506 | ||||
Sequence: A → T | ||||||
Sequence conflict | 222 | in Ref. 11; AAH95506 | ||||
Sequence: I → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF411110 EMBL· GenBank· DDBJ | AAL26481.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU809458 EMBL· GenBank· DDBJ | ACJ03844.1 EMBL· GenBank· DDBJ | mRNA | ||
AF345568 EMBL· GenBank· DDBJ | AAK29071.1 EMBL· GenBank· DDBJ | mRNA | ||
AB065866 EMBL· GenBank· DDBJ | BAC06084.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY507143 EMBL· GenBank· DDBJ | AAR92485.1 EMBL· GenBank· DDBJ | mRNA | ||
AK313955 EMBL· GenBank· DDBJ | BAG36671.1 EMBL· GenBank· DDBJ | mRNA | ||
AB083631 EMBL· GenBank· DDBJ | BAB89344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ157221 EMBL· GenBank· DDBJ | AAZ67915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC026333 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471054 EMBL· GenBank· DDBJ | EAW98337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC066881 EMBL· GenBank· DDBJ | AAH66881.1 EMBL· GenBank· DDBJ | mRNA | ||
BC066882 EMBL· GenBank· DDBJ | AAH66882.1 EMBL· GenBank· DDBJ | mRNA | ||
BC066883 EMBL· GenBank· DDBJ | AAH66883.1 EMBL· GenBank· DDBJ | mRNA | ||
BC067484 EMBL· GenBank· DDBJ | AAH67484.1 EMBL· GenBank· DDBJ | mRNA | ||
BC095506 EMBL· GenBank· DDBJ | AAH95506.1 EMBL· GenBank· DDBJ | mRNA |