Q9BXC0 · HCAR1_HUMAN

  • Protein
    Hydroxycarboxylic acid receptor 1
  • Gene
    HCAR1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processnegative regulation of lipid catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxycarboxylic acid receptor 1
  • Alternative names
    • G-protein coupled receptor 104
    • G-protein coupled receptor 81

Gene names

    • Name
      HCAR1
    • Synonyms
      GPR104, GPR81, HCA1
    • ORF names
      FKSG80

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BXC0
  • Secondary accessions
    • B2R9X4
    • Q3Y5J3
    • Q4VBN1
    • Q6NXU5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-21Extracellular
Transmembrane22-42Helical; Name=1
Topological domain43-49Cytoplasmic
Transmembrane50-70Helical; Name=2
Topological domain71-89Extracellular
Transmembrane90-110Helical; Name=3
Topological domain111-130Cytoplasmic
Transmembrane131-151Helical; Name=4
Topological domain152-182Extracellular
Transmembrane183-203Helical; Name=5
Topological domain204-220Cytoplasmic
Transmembrane221-241Helical; Name=6
Topological domain242-261Extracellular
Transmembrane262-281Helical; Name=7
Topological domain282-346Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_02515143in dbSNP:rs35292336
Mutagenesis99Diminishes the response to L-lactate.
Mutagenesis233Diminishes the response to L-lactate.
Mutagenesis240Diminishes the response to L-lactate.
Natural variantVAR_025152253
Natural variantVAR_061218253in dbSNP:rs36124671
Mutagenesis267Diminishes the response to L-lactate.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 461 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000695861-346Hydroxycarboxylic acid receptor 1
Glycosylation3N-linked (GlcNAc...) asparagine
Disulfide bond88↔165

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    39,295
  • Last updated
    2001-06-01 v1
  • Checksum
    E0DB114EEB3A47A5
MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict38in Ref. 11; AAH95506
Sequence conflict113in Ref. 11; AAH66883
Sequence conflict187in Ref. 11; AAH95506
Sequence conflict213in Ref. 11; AAH95506
Sequence conflict222in Ref. 11; AAH95506

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF411110
EMBL· GenBank· DDBJ
AAL26481.1
EMBL· GenBank· DDBJ
Genomic DNA
EU809458
EMBL· GenBank· DDBJ
ACJ03844.1
EMBL· GenBank· DDBJ
mRNA
AF345568
EMBL· GenBank· DDBJ
AAK29071.1
EMBL· GenBank· DDBJ
mRNA
AB065866
EMBL· GenBank· DDBJ
BAC06084.1
EMBL· GenBank· DDBJ
Genomic DNA
AY507143
EMBL· GenBank· DDBJ
AAR92485.1
EMBL· GenBank· DDBJ
mRNA
AK313955
EMBL· GenBank· DDBJ
BAG36671.1
EMBL· GenBank· DDBJ
mRNA
AB083631
EMBL· GenBank· DDBJ
BAB89344.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ157221
EMBL· GenBank· DDBJ
AAZ67915.1
EMBL· GenBank· DDBJ
Genomic DNA
AC026333
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471054
EMBL· GenBank· DDBJ
EAW98337.1
EMBL· GenBank· DDBJ
Genomic DNA
BC066881
EMBL· GenBank· DDBJ
AAH66881.1
EMBL· GenBank· DDBJ
mRNA
BC066882
EMBL· GenBank· DDBJ
AAH66882.1
EMBL· GenBank· DDBJ
mRNA
BC066883
EMBL· GenBank· DDBJ
AAH66883.1
EMBL· GenBank· DDBJ
mRNA
BC067484
EMBL· GenBank· DDBJ
AAH67484.1
EMBL· GenBank· DDBJ
mRNA
BC095506
EMBL· GenBank· DDBJ
AAH95506.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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