Q9BWT7 · CAR10_HUMAN

  • Protein
    Caspase recruitment domain-containing protein 10
  • Gene
    CARD10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.

Caution

Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCBM complex
Cellular Componentcytoplasm
Molecular FunctionCARD domain binding
Molecular Functionsignaling receptor complex adaptor activity
Biological Processactivation of NF-kappaB-inducing kinase activity
Biological Processnegative regulation of cell migration involved in sprouting angiogenesis
Biological Processpositive regulation of protein localization to nucleus
Biological Processprotein-containing complex assembly
Biological Processregulation of apoptotic process

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Caspase recruitment domain-containing protein 10
  • Alternative names
    • CARD-containing MAGUK protein 3 (Carma 3)

Gene names

    • Name
      CARD10
    • Synonyms
      CARMA3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BWT7
  • Secondary accessions
    • Q14CQ8
    • Q5TFG6
    • Q8NC81
    • Q9UGR5
    • Q9UGR6
    • Q9Y3H0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Involvement in disease

Immunodeficiency 89 and autoimmunity (IMD89)

  • Note
    • The disease may be caused by variants affecting the gene represented in this entry
  • Description
    An autosomal recessive disorder characterized by adult onset of recurrent infections, allergies, microcytic anemia, and Crohn disease.
  • See also
    MIM:619632
Natural variants in IMD89
Variant IDPosition(s)ChangeDescription
VAR_086467420R>Cin IMD89; uncertain significance; decreased protein expression compared to wild type when transfected in HEK293T cells

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_028116289in dbSNP:rs9610775
Natural variantVAR_086467420in IMD89; uncertain significance; decreased protein expression compared to wild type when transfected in HEK293T cells

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,271 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00001440841-1032UniProtCaspase recruitment domain-containing protein 10
Modified residue18UniProtPhosphoserine
Modified residue (large scale data)18PRIDEPhosphoserine
Modified residue (large scale data)551PRIDEPhosphoserine
Modified residue (large scale data)571PRIDEPhosphoserine
Modified residue (large scale data)606PRIDEPhosphoserine
Modified residue (large scale data)638PRIDEPhosphoserine
Modified residue (large scale data)815PRIDEPhosphoserine
Modified residue (large scale data)901PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Gene expression databases

Organism-specific databases

Interaction

Subunit

CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).
Interacts with TMEM43; this interaction is essential for EGFR-mediated NF-kappa-B activation (PubMed:27991920).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9BWT7BAHD1 Q8TBE03EBI-3866279, EBI-742750
BINARY Q9BWT7BCL6B A8KA133EBI-3866279, EBI-10174813
BINARY Q9BWT7C8orf48 Q96LL43EBI-3866279, EBI-751596
BINARY Q9BWT7CARD9 Q9H257-23EBI-3866279, EBI-11530605
BINARY Q9BWT7CATSPER1 Q8NEC53EBI-3866279, EBI-744545
BINARY Q9BWT7CBX8 Q9HC523EBI-3866279, EBI-712912
BINARY Q9BWT7CCDC116 Q8IYX33EBI-3866279, EBI-744311
BINARY Q9BWT7CDC37 Q165433EBI-3866279, EBI-295634
BINARY Q9BWT7CEP95 Q96GE43EBI-3866279, EBI-372775
BINARY Q9BWT7CHIC2 Q9UKJ53EBI-3866279, EBI-741528
BINARY Q9BWT7CNNM3 Q8NE013EBI-3866279, EBI-741032
BINARY Q9BWT7CWF19L2 Q2TBE03EBI-3866279, EBI-5453285
BINARY Q9BWT7CYSRT1 A8MQ033EBI-3866279, EBI-3867333
BINARY Q9BWT7DHX57 Q6P1583EBI-3866279, EBI-1051531
BINARY Q9BWT7DOCK2 Q926083EBI-3866279, EBI-448771
BINARY Q9BWT7DUSP26 Q9BV473EBI-3866279, EBI-2924519
BINARY Q9BWT7FAM47B Q8NA703EBI-3866279, EBI-9247344
BINARY Q9BWT7FOXD4L3 Q6VB843EBI-3866279, EBI-11961494
BINARY Q9BWT7GADD45GIP1 Q8TAE83EBI-3866279, EBI-372506
BINARY Q9BWT7GAS8 O959953EBI-3866279, EBI-1052570
BINARY Q9BWT7GFAP P141363EBI-3866279, EBI-744302
BINARY Q9BWT7GPATCH2L Q9NWQ4-13EBI-3866279, EBI-11959863
BINARY Q9BWT7GSE1 Q146873EBI-3866279, EBI-372619
BINARY Q9BWT7GSTP1 P092113EBI-3866279, EBI-353467
BINARY Q9BWT7HBZ P020083EBI-3866279, EBI-719843
BINARY Q9BWT7HOXB9 P174823EBI-3866279, EBI-745290
BINARY Q9BWT7IL16 Q14005-23EBI-3866279, EBI-17178971
BINARY Q9BWT7JOSD1 Q150403EBI-3866279, EBI-2510602
BINARY Q9BWT7KANK2 Q63ZY33EBI-3866279, EBI-2556193
BINARY Q9BWT7KDM1A O603413EBI-3866279, EBI-710124
BINARY Q9BWT7KEAP1 Q141453EBI-3866279, EBI-751001
BINARY Q9BWT7KRT75 O956783EBI-3866279, EBI-2949715
BINARY Q9BWT7KRTAP10-8 P604103EBI-3866279, EBI-10171774
BINARY Q9BWT7KRTAP12-3 P603283EBI-3866279, EBI-11953334
BINARY Q9BWT7KRTAP26-1 Q6PEX33EBI-3866279, EBI-3957672
BINARY Q9BWT7KRTAP9-2 Q9BYQ43EBI-3866279, EBI-1044640
BINARY Q9BWT7KRTAP9-3 Q9BYQ33EBI-3866279, EBI-1043191
BINARY Q9BWT7LENG1 Q96BZ83EBI-3866279, EBI-726510
BINARY Q9BWT7MAGOHB Q96A723EBI-3866279, EBI-746778
BINARY Q9BWT7METTL17 Q9H7H0-23EBI-3866279, EBI-11098807
BINARY Q9BWT7MGC50722 Q8IVT43EBI-3866279, EBI-14086479
BINARY Q9BWT7MITD1 Q8WV923EBI-3866279, EBI-2691489
BINARY Q9BWT7MYPOP Q86VE03EBI-3866279, EBI-2858213
BINARY Q9BWT7NME7 Q9Y5B83EBI-3866279, EBI-744782
BINARY Q9BWT7OLIG3 Q7RTU33EBI-3866279, EBI-10225049
BINARY Q9BWT7PIBF1 Q4G0R13EBI-3866279, EBI-14066006
BINARY Q9BWT7PKP1 Q13835-23EBI-3866279, EBI-9087684
BINARY Q9BWT7PNKP Q96T603EBI-3866279, EBI-1045072
BINARY Q9BWT7PRDM14 Q9GZV83EBI-3866279, EBI-3957793
BINARY Q9BWT7PRPF18 Q996333EBI-3866279, EBI-2798416
BINARY Q9BWT7PRPF3 O433953EBI-3866279, EBI-744322
BINARY Q9BWT7PRR35 P0CG203EBI-3866279, EBI-11986293
BINARY Q9BWT7PTCD1 O751273EBI-3866279, EBI-2560233
BINARY Q9BWT7PTGDS P412223EBI-3866279, EBI-948821
BINARY Q9BWT7RIN1 Q136713EBI-3866279, EBI-366017
BINARY Q9BWT7SCNM1 Q9BWG63EBI-3866279, EBI-748391
BINARY Q9BWT7SEMA3B Q13214-23EBI-3866279, EBI-11017428
BINARY Q9BWT7SPATA18 Q8TC713EBI-3866279, EBI-11334239
BINARY Q9BWT7SPMIP2 Q96LM53EBI-3866279, EBI-12020542
BINARY Q9BWT7TBC1D22B Q9NU193EBI-3866279, EBI-8787464
BINARY Q9BWT7TFAP2D Q7Z6R93EBI-3866279, EBI-11952651
BINARY Q9BWT7TRIM27 P143733EBI-3866279, EBI-719493
BINARY Q9BWT7TRIM41 Q8WV443EBI-3866279, EBI-725997
BINARY Q9BWT7USP54 Q70EL1-93EBI-3866279, EBI-11975223
BINARY Q9BWT7UTP14C Q5TAP63EBI-3866279, EBI-11737646
BINARY Q9BWT7ZBTB26 Q9HCK03EBI-3866279, EBI-3918996
BINARY Q9BWT7ZFP1 Q6P2D03EBI-3866279, EBI-2555749
BINARY Q9BWT7ZNF10 P215063EBI-3866279, EBI-1105324
BINARY Q9BWT7ZNF12 P170143EBI-3866279, EBI-11278550
BINARY Q9BWT7ZNF165 P499103EBI-3866279, EBI-741694
BINARY Q9BWT7ZNF180 Q9UJW8-43EBI-3866279, EBI-12055755
BINARY Q9BWT7ZNF202 O951253EBI-3866279, EBI-751960
BINARY Q9BWT7ZNF223 Q9UK113EBI-3866279, EBI-10322867
BINARY Q9BWT7ZNF239 Q166003EBI-3866279, EBI-8787052
BINARY Q9BWT7ZNF250 P15622-33EBI-3866279, EBI-10177272
BINARY Q9BWT7ZNF285 Q96NJ33EBI-3866279, EBI-18064466
BINARY Q9BWT7ZNF286A Q9HBT83EBI-3866279, EBI-10754950
BINARY Q9BWT7ZNF32 P170413EBI-3866279, EBI-1965483
BINARY Q9BWT7ZNF329 Q86UD43EBI-3866279, EBI-7233259
BINARY Q9BWT7ZNF366 Q8N8953EBI-3866279, EBI-2813661
BINARY Q9BWT7ZNF414 Q96IQ93EBI-3866279, EBI-744257
BINARY Q9BWT7ZNF415 Q09FC8-43EBI-3866279, EBI-12273744
BINARY Q9BWT7ZNF439 Q8NDP43EBI-3866279, EBI-747580
BINARY Q9BWT7ZNF440 Q8IYI83EBI-3866279, EBI-726439
BINARY Q9BWT7ZNF524 Q96C553EBI-3866279, EBI-10283126
BINARY Q9BWT7ZNF552 Q9H7073EBI-3866279, EBI-2555731
BINARY Q9BWT7ZNF559 Q9BR843EBI-3866279, EBI-746605
BINARY Q9BWT7ZNF564 Q8TBZ83EBI-3866279, EBI-10273713
BINARY Q9BWT7ZNF575 Q86XF73EBI-3866279, EBI-14069183
BINARY Q9BWT7ZNF581 Q9P0T43EBI-3866279, EBI-745520
BINARY Q9BWT7ZNF587 Q96SQ53EBI-3866279, EBI-6427977
BINARY Q9BWT7ZNF613 Q6PF043EBI-3866279, EBI-12062855
BINARY Q9BWT7ZNF670 Q9BS343EBI-3866279, EBI-745276
BINARY Q9BWT7ZNF775 Q96BV03EBI-3866279, EBI-7149881
BINARY Q9BWT7ZNF80 P515043EBI-3866279, EBI-12013828
BINARY Q9BWT7ZNF837 Q96EG33EBI-3866279, EBI-11962574
BINARY Q9BWT7ZSCAN25 Q6NSZ9-23EBI-3866279, EBI-14650477
View interactors in UniProtKB
View CPX-8902 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain, coiled coil.

TypeIDPosition(s)Description
Region1-23Disordered
Domain23-115CARD
Coiled coil138-456
Region253-276Disordered
Region481-553Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9BWT7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,032
  • Mass (Da)
    115,931
  • Last updated
    2006-10-17 v2
  • Checksum
    298AAC132778376A
MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA

Q9BWT7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-17: MPGRAEAGEAEEEAGAG → MGVGVGLGNGLRLLPWM
    • 18-303: Missing

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B0QYC3B0QYC3_HUMANCARD10192
B0QYC4B0QYC4_HUMANCARD10480

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0555231-17in isoform 2
Alternative sequenceVSP_05552418-303in isoform 2
Sequence conflict932in Ref. 1; AAK26165 and 2; AAK54454

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY028896
EMBL· GenBank· DDBJ
AAK26165.1
EMBL· GenBank· DDBJ
mRNA
AY032928
EMBL· GenBank· DDBJ
AAK54454.1
EMBL· GenBank· DDBJ
mRNA
AK074906
EMBL· GenBank· DDBJ
BAC11282.1
EMBL· GenBank· DDBJ
mRNA
AL022315
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
FP325335
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC113659
EMBL· GenBank· DDBJ
AAI13660.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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