Q9BVJ7 · DUS23_HUMAN
- ProteinDual specificity protein phosphatase 23
- GeneDUSP23
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids150 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
1.498 mM | p-nitrophenylphosphate |
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 95 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Molecular Function | protein tyrosine/serine/threonine phosphatase activity | |
Biological Process | cilium assembly | |
Biological Process | dephosphorylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity protein phosphatase 23
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BVJ7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Mainly cytosolic. Also nuclear.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_051756 | 124 | in dbSNP:rs11544443 | |||
Sequence: E → V | ||||||
Natural variant | VAR_023199 | 131 | in dbSNP:rs1129923 | |||
Sequence: G → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 229 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000094835 | 2-150 | Dual specificity protein phosphatase 23 | |||
Sequence: GVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK |
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9BVJ7 | ASB6 Q9NWX5 | 3 | EBI-724940, EBI-6425205 | |
BINARY | Q9BVJ7 | BANF2 Q9H503-2 | 3 | EBI-724940, EBI-11977289 | |
BINARY | Q9BVJ7 | DDIT4L Q96D03 | 3 | EBI-724940, EBI-742054 | |
BINARY | Q9BVJ7 | EXOSC8 Q96B26 | 12 | EBI-724940, EBI-371922 | |
BINARY | Q9BVJ7 | MRNIP Q6NTE8 | 3 | EBI-724940, EBI-2857471 | |
BINARY | Q9BVJ7 | NIF3L1 Q9GZT8 | 3 | EBI-724940, EBI-740897 | |
BINARY | Q9BVJ7 | PSMB8 P28062-2 | 5 | EBI-724940, EBI-372312 | |
BINARY | Q9BVJ7 | PSME2 Q9UL46 | 3 | EBI-724940, EBI-741630 | |
BINARY | Q9BVJ7 | TCF4 P15884-3 | 3 | EBI-724940, EBI-13636688 | |
BINARY | Q9BVJ7 | UBA3 Q8TBC4 | 3 | EBI-724940, EBI-717567 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-150 | Tyrosine-protein phosphatase | ||||
Sequence: NFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length150
- Mass (Da)16,588
- Last updated2001-06-01 v1
- Checksum4B72EFA0434B1B5F
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 132 | in Ref. 2; BAA91172 | ||||
Sequence: S → P |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB164404 EMBL· GenBank· DDBJ | BAD12141.1 EMBL· GenBank· DDBJ | mRNA | ||
AK000449 EMBL· GenBank· DDBJ | BAA91172.1 EMBL· GenBank· DDBJ | mRNA | ||
AL590560 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC001140 EMBL· GenBank· DDBJ | AAH01140.1 EMBL· GenBank· DDBJ | mRNA |