Q9BTX3 · TM208_HUMAN

  • Protein
    Transmembrane protein 208
  • Gene
    TMEM208
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentvacuole
Biological Processautophagy
Biological Processvacuolar protein processing

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 9.B.26.1.1the regulator of er stress and autophagy tmem208 (tmem208) family
Community curation (1)

Involved in protein targeting to the endoplasmic reticulum (ER). Part of the SRP-indepent pathway of protein targeting to the ER.

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane protein 208

Gene names

    • Name
      TMEM208
    • ORF names
      HSPC171
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BTX3
  • Secondary accessions
    • Q05CT0
    • Q96D25
    • Q9NZZ7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-45Helical
Transmembrane51-68Helical
Transmembrane105-129Helical

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_08970927found in a child with developmental delay, skeletal abnormalities, multiple hair whorls, cardiac and neurological issues; uncertain significance; partially rescues the lethality in the fruit fly model; no effect on localization to the endoplasmic reticulum membrane
Natural variantVAR_03995882in dbSNP:rs17851038
Natural variantVAR_053933102in dbSNP:rs11553801

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 196 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00003259671-173Transmembrane protein 208

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region152-173Disordered

Sequence similarities

Belongs to the TMEM208 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9BTX3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    173
  • Mass (Da)
    19,642
  • Last updated
    2001-06-01 v1
  • Checksum
    F6AE0798B79967A6
MAPKGKVGTRGKKQIFEENRETLKFYLRIILGANAIYCLVTLVFFYSSASFWAWLALGFSLAVYGASYHSMSSMARAAFSEDGALMDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYVWSFWLLAPGRALYLLWVNVLGPWFTADSGTPAPEHNEKRQRRQERRQMKRL

Q9BTX3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KRY7J3KRY7_HUMANTMEM208103
H3BMW4H3BMW4_HUMANTMEM208140
J3QRY9J3QRY9_HUMANTMEM20836

Sequence caution

The sequence AAF29134.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict90in Ref. 1; AAF29134
Alternative sequenceVSP_032505101-173in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF161519
EMBL· GenBank· DDBJ
AAF29134.1
EMBL· GenBank· DDBJ
mRNA Frameshift
CH471092
EMBL· GenBank· DDBJ
EAW83106.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471092
EMBL· GenBank· DDBJ
EAW83107.1
EMBL· GenBank· DDBJ
Genomic DNA
BC003080
EMBL· GenBank· DDBJ
AAH03080.1
EMBL· GenBank· DDBJ
mRNA
BC021109
EMBL· GenBank· DDBJ
AAH21109.1
EMBL· GenBank· DDBJ
mRNA
BC013412
EMBL· GenBank· DDBJ
AAH13412.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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