Q9BSF0 · SMAKA_HUMAN

  • Protein
    Small membrane A-kinase anchor protein
  • Gene
    C2orf88
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionprotein kinase A regulatory subunit binding

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Small membrane A-kinase anchor protein
  • Short names
    Small membrane AKAP; smAKAP

Gene names

    • Name
      C2orf88

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BSF0
  • Secondary accessions
    • D3DPI3
    • P0C876
    • Q53TC7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
Note: The GFP-tagged protein has been detected at the plasma membrane, enriched in filopodia and cell-cell junctions.

Keywords

Disease & Variants

Features

Showing features for mutagenesis, natural variant.

TypeIDPosition(s)Description
Mutagenesis2Loss of plasma membrane localization.
Mutagenesis3Loss of plasma membrane localization.
Natural variantVAR_04615156in dbSNP:rs6753459

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 135 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Lipidation2UniProtN-myristoyl glycine
ChainPRO_00003484302-95UniProtSmall membrane A-kinase anchor protein
Lipidation3UniProtS-palmitoyl cysteine
Modified residue40UniProtPhosphoserine
Modified residue (large scale data)40PRIDEPhosphoserine
Modified residue (large scale data)66PRIDEPhosphoserine
Modified residue92UniProtPhosphoserine

Post-translational modification

May be palmitoylated at Cys-3.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in heart (at protein level).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with PRKAR1A and PRKAR1B.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region56-74PKA-RI-binding

Sequence similarities

Belongs to the small membrane AKAP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    95
  • Mass (Da)
    10,970
  • Last updated
    2008-09-02 v2
  • Checksum
    9E6DDFAF29F29551
MGCMKSKQTFPFPTIYEGEKQHESEEPFMPEERCLPRMASPVNVKEEVKEPPGTNTVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEGP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
C9JS57C9JS57_HUMANC2orf8830
H7BZ15H7BZ15_HUMANC2orf8867

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict26in Ref. 2; AK075168

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK313395
EMBL· GenBank· DDBJ
BAG36193.1
EMBL· GenBank· DDBJ
mRNA
AK075168
EMBL· GenBank· DDBJ
-mRNA No translation available.
AC010679
EMBL· GenBank· DDBJ
AAX93233.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471058
EMBL· GenBank· DDBJ
EAX10878.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471058
EMBL· GenBank· DDBJ
EAX10879.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005083
EMBL· GenBank· DDBJ
AAH05083.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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