Q9BPX5 · ARP5L_HUMAN

  • Protein
    Actin-related protein 2/3 complex subunit 5-like protein
  • Gene
    ARPC5L
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentArp2/3 protein complex
Cellular Componentcytoplasm
Cellular Componentextracellular exosome
Cellular Componentfocal adhesion
Cellular Componentglutamatergic synapse
Molecular Functionactin filament binding
Biological ProcessArp2/3 complex-mediated actin nucleation
Biological Processcell migration
Biological Processregulation of actin filament polymerization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Actin-related protein 2/3 complex subunit 5-like protein
  • Alternative names
    • Arp2/3 complex 16 kDa subunit 2 (ARC16-2)

Gene names

    • Name
      ARPC5L

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BPX5
  • Secondary accessions
    • Q7Z523

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 158 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002794801-153UniProt
Modified residue64UniProtPhosphoserine
Modified residue (large scale data)64PRIDEPhosphoserine
Modified residue (large scale data)68PRIDEPhosphothreonine
Modified residue (large scale data)142PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

May be a component of the Arp2/3 complex in which it may replace ARPC5.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9BPX5ARPC4 P599988EBI-711189, EBI-351872
BINARY Q9BPX5GADD45G O952574EBI-711189, EBI-448202
BINARY Q9BPX5NSMF Q6X4W1-23EBI-711189, EBI-12028784
View interactors in UniProtKB
View CPX-2580 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the ARPC5 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    16,941
  • Last updated
    2001-06-01 v1
  • Checksum
    D8E4772404300560
MARNTLSSRFRRVDIDEFDENKFVDEQEEAAAAAAEPGPDPSEVDGLLRQGDMLRAFHAALRNSPVNTKNQAVKERAQGVVLKVLTNFKSSEIEQAVQSLDRNGVDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict30in Ref. 1; AAP97155
Sequence conflict36-37in Ref. 1; AAP97155

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF087842
EMBL· GenBank· DDBJ
AAP97155.1
EMBL· GenBank· DDBJ
mRNA
AL354928
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC000018
EMBL· GenBank· DDBJ
AAH00018.1
EMBL· GenBank· DDBJ
mRNA
BC000798
EMBL· GenBank· DDBJ
AAH00798.1
EMBL· GenBank· DDBJ
mRNA
BC002418
EMBL· GenBank· DDBJ
AAH02418.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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