Q9BPE9 · CTA1_CONPE

Function

function

Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2). Of the 3 native isomers, only the isomer with a ribbon disulfide configuration shows pharmacological activity and 3D structure similar to other chi-conotoxins. This ribbon isomer (disulfide pattern: C1-C4 and C2-C3) inhibits the rat norepinephrine transporter (IC50=10 uM). In contrast, the globular isomer of PnID shows more than ten times less activity against this transporter and the beaded isomer does not display any measurable biological activity.

Miscellaneous

Negative results: the 3 native isomers do not produce effects on the activity of the dopamine transporter (DAT/SLC6A3) and the serotonin transporter (SERT/SLC6A4).

Caution

In contrast to other chi-conotoxins, no proline hydroxylation has been described.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Chi-conotoxin PnID
  • Short names
    PnID A
    ; PnID B
    ; PnID C
  • Alternative names
    • Chi-conotoxin-like PnMRCL-013
    • Conotoxin Pn10.1

Organism names

Accessions

  • Primary accession
    Q9BPE9

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, peptide, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-22
PropeptidePRO_000040497923-51
PeptidePRO_000040498052-63Chi-conotoxin PnID
Disulfide bond54↔55beaded isomer; alternate
Disulfide bond54↔60globular isomer; alternate
Disulfide bond54↔63ribbon isomer; alternate
Disulfide bond55↔60ribbon isomer; alternate
Disulfide bond55↔63globular isomer; alternate
Disulfide bond60↔63beaded isomer; alternate
Modified residue63Cysteine amide

Post-translational modification

Three isomers are found in the venom. The ribbon isomer (C1-C4, C2-C3) is the only one active towards noradrenaline transporters.

Keywords

Expression

Tissue specificity

Expressed by the venom duct.

Family & Domains

Domain

The cysteine framework is I (CC-C-C). Alpha4/2 pattern.

Sequence similarities

Belongs to the conotoxin T superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    64
  • Mass (Da)
    6,928
  • Last updated
    2001-06-01 v1
  • Checksum
    0AB87620FCCC1410
MRCLPVFVILLLLTASGPSVDAKVHLKTKGDGPLSSFRDNAKSTLQRLQDKSTCCGYRMCVPCG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF214980
EMBL· GenBank· DDBJ
AAG60408.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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