Q9BKQ5 · REP1_CAEEL
- ProteinRab proteins geranylgeranyltransferase component A 1
- Generep-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids510 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex (By similarity).
Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B and remains bound to it after the geranylgeranyl transfer reaction (By similarity).
The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane (By similarity).
Plays a role in neurotransmitter release from presynaptic terminals at neuromuscular junctions (PubMed:19090809).
Positively regulates the function of rab-27 in synaptic transmission most likely through mediating rab-27 prenylation (PubMed:19090809).
Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B and remains bound to it after the geranylgeranyl transfer reaction (By similarity).
The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane (By similarity).
Plays a role in neurotransmitter release from presynaptic terminals at neuromuscular junctions (PubMed:19090809).
Positively regulates the function of rab-27 in synaptic transmission most likely through mediating rab-27 prenylation (PubMed:19090809).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | Rab-protein geranylgeranyltransferase complex | |
Molecular Function | GTPase activator activity | |
Molecular Function | Rab GDP-dissociation inhibitor activity | |
Biological Process | intracellular protein transport | |
Biological Process | protein geranylgeranylation | |
Biological Process | small GTPase-mediated signal transduction | |
Biological Process | vesicle-mediated transport |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRab proteins geranylgeranyltransferase component A 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ9BKQ5
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown results in mild defecation defects (PubMed:19090809).
RNAi-mediated knockdown increases the levels of unprenylated rab-27 (PubMed:19090809).
RNAi-mediated knockdown disrupts the localization of rab-5 and rab-7 (PubMed:19090809).
RNAi-mediated knockdown increases the levels of unprenylated rab-27 (PubMed:19090809).
RNAi-mediated knockdown disrupts the localization of rab-5 and rab-7 (PubMed:19090809).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 107 | In ta208; embryonic lethality in some animals and reduces brood size. Some animals have abnormal germ-line development and gonad morphology. In severely affected animals, either gonads fail to develop or small traces of gonads are located around the vulva. Mild defecation defects. Disrupts the localization of rab-5, rab-7 and rab-27. Reduces the number of body bends in response to exogenous melatonin. Mild resistance to the acetylcholinesterase inhibitor aldicarb. However, induces paralysis in response to aldicarb in some animals. | ||||
Sequence: E → K |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454726 | 1-510 | Rab proteins geranylgeranyltransferase component A 1 | |||
Sequence: MDEKLPESVDVVVLGTGLPEAILASACARAGLSVLHLDRNEYYGGDWSSFTMSMVHEVTENQVKKLDSSEISKLSELLTENEQLIELGNREIVENIEMTWIPRGKDEEKPMKTQLEEASQMRRFSIDLVPKILLSKGAMVQTLCDSQVSHYAEFKLVNRQLCPTETPEAGITLNPVPCSKGEIFQSNALSILEKRALMKFITFCTQWSTKDTEEGRKLLAEHADRPFSEFLEQMGVGKTLQSFIINTIGILQQRPTAMTGMLASCQFMDSVGHFGPSPFLFPLYGCGELSQCFCRLAAVFGSLYCLGRPVQAIVKKDGKITAVIANGDRVNCRYIVMSPRFVPETVPASSTLKIERIVYATDKSIKEAEKEQLTLLNLASLRPDAAVSRLVEVGFEACTAPKGHFLVHATGTQEGETSVKTIAEKIFEKNEVEPYWKMSFTANSMKFDTAGAENVVVAPPVDANLHYASVVEECRQLFCTTWPELDFLPRAMKKEEEEEEEPETEEIAEN |
Proteomic databases
Expression
Tissue specificity
Expressed in several neurons including head neurons, motor neurons located in the ventral nerve cord, HSN and CAN neurons, and tail neurons, and in muscles such as body-wall, pharyngeal, intestinal and anal sphincter (PubMed:19090809).
Also expressed in seam cells, the hypodermis and the intestine (PubMed:19090809).
Also expressed in seam cells, the hypodermis and the intestine (PubMed:19090809).
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length510
- Mass (Da)56,838
- Last updated2001-06-01 v1
- Checksum5037C7772C618620
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284603 EMBL· GenBank· DDBJ | CCD73025.1 EMBL· GenBank· DDBJ | Genomic DNA |