Q9BKJ1 · SCN2_MESMA
- ProteinAnti-neuroexcitation peptide 2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Binds to sodium channels (Nav) and inhibits them (By similarity).
Recombinant ANEP delays the convulsion seizure of insect models by 18% and shows anti-neuroexcitatory activity
Recombinant ANEP delays the convulsion seizure of insect models by 18% and shows anti-neuroexcitatory activity
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 55 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: Y | ||||||
Site | 57 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: W | ||||||
Site | 60 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: G | ||||||
Site | 61 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: L | ||||||
Site | 74 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: W | ||||||
Site | 79 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: N | ||||||
Site | 82 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: G | ||||||
Site | 83 | Binds the drosophila sodium channel DmNav1 | ||||
Sequence: G |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | sodium channel inhibitor activity | |
Molecular Function | toxin activity | |
Biological Process | defense response |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameAnti-neuroexcitation peptide 2
- Short namesBmKANEP2
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Scorpiones > Buthida > Buthoidea > Buthidae > Mesobuthus
Accessions
- Primary accessionQ9BKJ1
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MKLSLLLVISASMLIDGLVNA | ||||||
Chain | PRO_0000035264 | 22-85 | Anti-neuroexcitation peptide 2 | |||
Sequence: DGYIRGSNGCKVSCLWGNDGCNKECRAYGASYGYCWTWGLACWCEGLPDDKTWKSESNTCGGKK | ||||||
Disulfide bond | 31↔81 | |||||
Sequence: CKVSCLWGNDGCNKECRAYGASYGYCWTWGLACWCEGLPDDKTWKSESNTC | ||||||
Disulfide bond | 35↔56 | |||||
Sequence: CLWGNDGCNKECRAYGASYGYC | ||||||
Disulfide bond | 42↔63 | |||||
Sequence: CNKECRAYGASYGYCWTWGLAC | ||||||
Disulfide bond | 46↔65 | |||||
Sequence: CRAYGASYGYCWTWGLACWC |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-82 | LCN-type CS-alpha/beta | ||||
Sequence: DGYIRGSNGCKVSCLWGNDGCNKECRAYGASYGYCWTWGLACWCEGLPDDKTWKSESNTCG |
Domain
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence similarities
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length85
- Mass (Da)9,225
- Last updated2001-06-01 v1
- ChecksumC045C7DACB3513AB