Q9BKJ1 · SCN2_MESMA

Function

function

Binds to sodium channels (Nav) and inhibits them (By similarity).
Recombinant ANEP delays the convulsion seizure of insect models by 18% and shows anti-neuroexcitatory activity

Features

Showing features for site.

1851020304050607080
MKLSLLLVISASMLIDGLVNADGYIRGSNGCKVSCLWGNDGCNKECRAYGASYGYCWTWGLACWCEGLPDDKTWKSESNTCGGKK
TypeIDPosition(s)Description
Site55Binds the drosophila sodium channel DmNav1
Site57Binds the drosophila sodium channel DmNav1
Site60Binds the drosophila sodium channel DmNav1
Site61Binds the drosophila sodium channel DmNav1
Site74Binds the drosophila sodium channel DmNav1
Site79Binds the drosophila sodium channel DmNav1
Site82Binds the drosophila sodium channel DmNav1
Site83Binds the drosophila sodium channel DmNav1

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionsodium channel inhibitor activity
Molecular Functiontoxin activity
Biological Processdefense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Anti-neuroexcitation peptide 2
  • Short names
    BmKANEP2
  • Alternative names
    • Anti-neuroexcitation peptide II (ANEPII)

Organism names

Accessions

  • Primary accession
    Q9BKJ1

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000003526422-85Anti-neuroexcitation peptide 2
Disulfide bond31↔81
Disulfide bond35↔56
Disulfide bond42↔63
Disulfide bond46↔65

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-82LCN-type CS-alpha/beta

Domain

Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    85
  • Mass (Da)
    9,225
  • Last updated
    2001-06-01 v1
  • Checksum
    C045C7DACB3513AB
MKLSLLLVISASMLIDGLVNADGYIRGSNGCKVSCLWGNDGCNKECRAYGASYGYCWTWGLACWCEGLPDDKTWKSESNTCGGKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF242736
EMBL· GenBank· DDBJ
AAK28341.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp