Q9BIS2 · HSP73_DROME

Function

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionheat shock protein binding
Molecular Functionprotein folding chaperone
Biological Processchaperone cofactor-dependent protein refolding
Biological Processheat shock-mediated polytene chromosome puffing
Biological Processprotein refolding
Biological Processresponse to heat
Biological Processresponse to hypoxia
Biological Processresponse to unfolded protein

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Major heat shock 70 kDa protein Bb
  • Short names
    Heat shock protein 70Bb
  • Alternative names
    • HSP70-87C1

Gene names

    • Name
      Hsp70Bb
    • ORF names
      CG31359

Organism names

  • Taxonomic identifier
  • Strains
    • 3CPA126
    • 3CPA2
    • 3CPA35
    • 3CPA43
    • 3CPA47
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9BIS2
  • Secondary accessions
    • B0BNN7
    • P02824
    • Q53XF0
    • Q5I7H2
    • Q5I7H4

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant43in strain: 3CPA86
Natural variant60in strain: FrV3-1
Natural variant67in Z(S)29
Natural variant71in Z(S)2
Natural variant187in strain: IS2, IS3, IS4, IS5, IS25 and QD18
Natural variant195in strain: ZZ30
Natural variant241in strain: Z(H)1
Natural variant350in strain: Z(H)1
Natural variant430in strain: Z(H)1
Natural variant437in strain: IS4 and IS5
Natural variant516in strain: B28
Natural variant524in strain: B28
Natural variant544in strain: Z(S)24 and Z(S)49
Natural variant606in strain: 3CPA126
Natural variant607in strain: Z(S)30A

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 15 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000783331-641Major heat shock 70 kDa protein Bb

Expression

Induction

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region609-641Disordered

Sequence similarities

Belongs to the heat shock protein 70 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    641
  • Mass (Da)
    70,195
  • Last updated
    2004-04-13 v2
  • Checksum
    F2C9C204F67EBB59
MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict26-28in Ref. 1; AAD15226
Sequence conflict48-50in Ref. 1; AAD15226
Sequence conflict306in Ref. 1; AAD15226

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J01104
EMBL· GenBank· DDBJ
AAD15226.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295951
EMBL· GenBank· DDBJ
AAG26905.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295952
EMBL· GenBank· DDBJ
AAG26906.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295953
EMBL· GenBank· DDBJ
AAG26907.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295954
EMBL· GenBank· DDBJ
AAG26908.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295955
EMBL· GenBank· DDBJ
AAG26909.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295956
EMBL· GenBank· DDBJ
AAG26910.1
EMBL· GenBank· DDBJ
Genomic DNA
AF295957
EMBL· GenBank· DDBJ
AAG26911.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350476
EMBL· GenBank· DDBJ
AAK30233.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350477
EMBL· GenBank· DDBJ
AAK30234.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350478
EMBL· GenBank· DDBJ
AAK30235.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350479
EMBL· GenBank· DDBJ
AAK30236.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350480
EMBL· GenBank· DDBJ
AAK30237.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350481
EMBL· GenBank· DDBJ
AAK30238.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350482
EMBL· GenBank· DDBJ
AAK30239.1
EMBL· GenBank· DDBJ
Genomic DNA
AF350483
EMBL· GenBank· DDBJ
AAK30240.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAN13546.1
EMBL· GenBank· DDBJ
Genomic DNA
BT011058
EMBL· GenBank· DDBJ
AAR31129.1
EMBL· GenBank· DDBJ
mRNA
BT011379
EMBL· GenBank· DDBJ
AAR96171.1
EMBL· GenBank· DDBJ
mRNA
BT031349
EMBL· GenBank· DDBJ
ABY76186.1
EMBL· GenBank· DDBJ
mRNA
AY846848
EMBL· GenBank· DDBJ
AAW34339.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846849
EMBL· GenBank· DDBJ
AAW34340.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846850
EMBL· GenBank· DDBJ
AAW34341.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846851
EMBL· GenBank· DDBJ
AAW34342.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846852
EMBL· GenBank· DDBJ
AAW34343.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846853
EMBL· GenBank· DDBJ
AAW34344.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846854
EMBL· GenBank· DDBJ
AAW34345.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846855
EMBL· GenBank· DDBJ
AAW34346.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846856
EMBL· GenBank· DDBJ
AAW34347.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846857
EMBL· GenBank· DDBJ
AAW34348.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846858
EMBL· GenBank· DDBJ
AAW34349.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846859
EMBL· GenBank· DDBJ
AAW34350.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846860
EMBL· GenBank· DDBJ
AAW34351.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846861
EMBL· GenBank· DDBJ
AAW34352.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846862
EMBL· GenBank· DDBJ
AAW34353.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846863
EMBL· GenBank· DDBJ
AAW34354.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846864
EMBL· GenBank· DDBJ
AAW34355.1
EMBL· GenBank· DDBJ
Genomic DNA
AY846865
EMBL· GenBank· DDBJ
AAW34356.1
EMBL· GenBank· DDBJ
Genomic DNA
AY370940
EMBL· GenBank· DDBJ
AAQ75092.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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