Q9BIS2 · HSP73_DROME
- ProteinMajor heat shock 70 kDa protein Bb
- GeneHsp70Bb
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids641 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Miscellaneous
Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent protein folding chaperone | |
Molecular Function | heat shock protein binding | |
Molecular Function | protein folding chaperone | |
Biological Process | chaperone cofactor-dependent protein refolding | |
Biological Process | heat shock-mediated polytene chromosome puffing | |
Biological Process | protein refolding | |
Biological Process | response to heat | |
Biological Process | response to hypoxia | |
Biological Process | response to unfolded protein |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMajor heat shock 70 kDa protein Bb
- Short namesHeat shock protein 70Bb
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9BIS2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 43 | in strain: 3CPA86 | ||||
Sequence: D → E | ||||||
Natural variant | 60 | in strain: FrV3-1 | ||||
Sequence: P → S | ||||||
Natural variant | 67 | in Z(S)29 | ||||
Sequence: A → P | ||||||
Natural variant | 71 | in Z(S)2 | ||||
Sequence: I → T | ||||||
Natural variant | 187 | in strain: IS2, IS3, IS4, IS5, IS25 and QD18 | ||||
Sequence: K → N | ||||||
Natural variant | 195 | in strain: ZZ30 | ||||
Sequence: F → L | ||||||
Natural variant | 241 | in strain: Z(H)1 | ||||
Sequence: E → D | ||||||
Natural variant | 350 | in strain: Z(H)1 | ||||
Sequence: E → D | ||||||
Natural variant | 430 | in strain: Z(H)1 | ||||
Sequence: S → A | ||||||
Natural variant | 437 | in strain: IS4 and IS5 | ||||
Sequence: S → P | ||||||
Natural variant | 516 | in strain: B28 | ||||
Sequence: M → I | ||||||
Natural variant | 524 | in strain: B28 | ||||
Sequence: A → V | ||||||
Natural variant | 544 | in strain: Z(S)24 and Z(S)49 | ||||
Sequence: V → I | ||||||
Natural variant | 606 | in strain: 3CPA126 | ||||
Sequence: K → T | ||||||
Natural variant | 607 | in strain: Z(S)30A | ||||
Sequence: M → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 15 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000078333 | 1-641 | Major heat shock 70 kDa protein Bb | |||
Sequence: MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD |
Expression
Induction
Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 609-641 | Disordered | ||||
Sequence: QQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD |
Sequence similarities
Belongs to the heat shock protein 70 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length641
- Mass (Da)70,195
- Last updated2004-04-13 v2
- ChecksumF2C9C204F67EBB59
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 26-28 | in Ref. 1; AAD15226 | ||||
Sequence: IAN → NAY | ||||||
Sequence conflict | 48-50 | in Ref. 1; AAD15226 | ||||
Sequence: IGD → NGE | ||||||
Sequence conflict | 306 | in Ref. 1; AAD15226 | ||||
Sequence: D → N |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J01104 EMBL· GenBank· DDBJ | AAD15226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295951 EMBL· GenBank· DDBJ | AAG26905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295952 EMBL· GenBank· DDBJ | AAG26906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295953 EMBL· GenBank· DDBJ | AAG26907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295954 EMBL· GenBank· DDBJ | AAG26908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295955 EMBL· GenBank· DDBJ | AAG26909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295956 EMBL· GenBank· DDBJ | AAG26910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF295957 EMBL· GenBank· DDBJ | AAG26911.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350476 EMBL· GenBank· DDBJ | AAK30233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350477 EMBL· GenBank· DDBJ | AAK30234.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350478 EMBL· GenBank· DDBJ | AAK30235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350479 EMBL· GenBank· DDBJ | AAK30236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350480 EMBL· GenBank· DDBJ | AAK30237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350481 EMBL· GenBank· DDBJ | AAK30238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350482 EMBL· GenBank· DDBJ | AAK30239.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF350483 EMBL· GenBank· DDBJ | AAK30240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAN13546.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT011058 EMBL· GenBank· DDBJ | AAR31129.1 EMBL· GenBank· DDBJ | mRNA | ||
BT011379 EMBL· GenBank· DDBJ | AAR96171.1 EMBL· GenBank· DDBJ | mRNA | ||
BT031349 EMBL· GenBank· DDBJ | ABY76186.1 EMBL· GenBank· DDBJ | mRNA | ||
AY846848 EMBL· GenBank· DDBJ | AAW34339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846849 EMBL· GenBank· DDBJ | AAW34340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846850 EMBL· GenBank· DDBJ | AAW34341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846851 EMBL· GenBank· DDBJ | AAW34342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846852 EMBL· GenBank· DDBJ | AAW34343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846853 EMBL· GenBank· DDBJ | AAW34344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846854 EMBL· GenBank· DDBJ | AAW34345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846855 EMBL· GenBank· DDBJ | AAW34346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846856 EMBL· GenBank· DDBJ | AAW34347.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846857 EMBL· GenBank· DDBJ | AAW34348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846858 EMBL· GenBank· DDBJ | AAW34349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846859 EMBL· GenBank· DDBJ | AAW34350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846860 EMBL· GenBank· DDBJ | AAW34351.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846861 EMBL· GenBank· DDBJ | AAW34352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846862 EMBL· GenBank· DDBJ | AAW34353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846863 EMBL· GenBank· DDBJ | AAW34354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846864 EMBL· GenBank· DDBJ | AAW34355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY846865 EMBL· GenBank· DDBJ | AAW34356.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY370940 EMBL· GenBank· DDBJ | AAQ75092.1 EMBL· GenBank· DDBJ | Genomic DNA |