Q9BE72 · GTR12_MACFA
- ProteinSolute carrier family 2, facilitated glucose transporter member 12
- GeneSLC2A12
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids621 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Insulin-independent facilitative glucose transporter.
Catalytic activity
- D-glucose(out) = D-glucose(in)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endomembrane system | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | glucose transmembrane transporter activity | |
Molecular Function | symporter activity | |
Biological Process | circulatory system development |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 2, facilitated glucose transporter member 12
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionQ9BE72
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endomembrane system ; Multi-pass membrane protein
Note: Localizes primarily perinuclear region in the absence of insulin.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-48 | Cytoplasmic | ||||
Sequence: MVPVENTEGPNLLNQKGTAVETEGSYRASGSRHPPWARGCGMFTFLSS | ||||||
Transmembrane | 49-69 | Helical | ||||
Sequence: VTAAVSGLLVGYELGIISGAL | ||||||
Topological domain | 70-84 | Extracellular | ||||
Sequence: LQIKTLLTLSCHEQE | ||||||
Transmembrane | 85-105 | Helical | ||||
Sequence: MVVSSLLIGALLASLTGGVLI | ||||||
Topological domain | 106-119 | Cytoplasmic | ||||
Sequence: DRYGRRTAIILSSC | ||||||
Transmembrane | 120-140 | Helical | ||||
Sequence: LLGLGSLVLILSLSYTVLIVG | ||||||
Topological domain | 141 | Extracellular | ||||
Sequence: R | ||||||
Transmembrane | 142-162 | Helical | ||||
Sequence: IAIGVSISLSSIATCVYIAEI | ||||||
Topological domain | 163-176 | Cytoplasmic | ||||
Sequence: APQHRRGLLVSLNE | ||||||
Transmembrane | 177-197 | Helical | ||||
Sequence: LMIVIGILSAYISNYAFANVF | ||||||
Topological domain | 198-201 | Extracellular | ||||
Sequence: HGWK | ||||||
Transmembrane | 202-222 | Helical | ||||
Sequence: YMFGLVIPLGILQAIAMYFLP | ||||||
Topological domain | 223-282 | Cytoplasmic | ||||
Sequence: PSPRFLVMKGQEGAASKVLGRLRALSDATEELTVIKSSLKDEYQYSFWDLFRSKDNMRTR | ||||||
Transmembrane | 283-303 | Helical | ||||
Sequence: IMIGLTLVFFVQITGQPNILF | ||||||
Topological domain | 304-321 | Extracellular | ||||
Sequence: YASTVLKSVGFQSNEAAS | ||||||
Transmembrane | 322-342 | Helical | ||||
Sequence: LASTGVGVVKVISTIPATLLV | ||||||
Topological domain | 343-349 | Cytoplasmic | ||||
Sequence: DHVGSKT | ||||||
Transmembrane | 350-370 | Helical | ||||
Sequence: FLCIGSSVMAASLVTMGIVNL | ||||||
Topological domain | 371-470 | Extracellular | ||||
Sequence: NIHMNFTNICRSHNSINQSLDESVIYGPGNLSASNNTLRDHFKGIASHSRSSLMPLRNDVDKRGETTSASLLNAVLSHTEYQIVTDPGDVPAFLKWLSLA | ||||||
Transmembrane | 471-491 | Helical | ||||
Sequence: SLLVYVAAFSIGLGPMPWLVL | ||||||
Topological domain | 492-502 | Cytoplasmic | ||||
Sequence: SEIFPGGIRGR | ||||||
Transmembrane | 503-523 | Helical | ||||
Sequence: AMALTSSMNWGINLLISLTFL | ||||||
Topological domain | 524-532 | Extracellular | ||||
Sequence: TVTDLIGLP | ||||||
Transmembrane | 533-553 | Helical | ||||
Sequence: WVCFIYTIMSLASLLFVVMFI | ||||||
Topological domain | 554-621 | Cytoplasmic | ||||
Sequence: PETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPRQPQKRKPQEQLLECNKLCGRGQSRQLSPEN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000292015 | 1-621 | Solute carrier family 2, facilitated glucose transporter member 12 | |||
Sequence: MVPVENTEGPNLLNQKGTAVETEGSYRASGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLTLSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGILQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDATEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTNICRSHNSINQSLDESVIYGPGNLSASNNTLRDHFKGIASHSRSSLMPLRNDVDKRGETTSASLLNAVLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPRQPQKRKPQEQLLECNKLCGRGQSRQLSPEN | ||||||
Glycosylation | 375 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 387 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 400 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 405 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length621
- Mass (Da)67,486
- Last updated2001-06-01 v1
- Checksum9E9384A2320AC716
Keywords
- Technical term