Q9B518 · Q9B518_AQULA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids134 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Elateriformia > Elateroidea > Lampyridae > Luciolinae > Aquatica
Accessions
- Primary accessionQ9B518
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 50-76 | Helical | ||||
Sequence: LAIFSLHLAGISSIMGAVNFISTIFNM | ||||||
Transmembrane | 88-115 | Helical | ||||
Sequence: LFVWAVLITAILLLLSLPVLAGAITMLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-28 | |||||
Sequence: RMNNMSFWLLPPSLSLLLMSSLVENGAG | ||||||
Chain | PRO_5010847648 | 29-134 | Cytochrome c oxidase subunit 1 | |||
Sequence: TGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSIMGAVNFISTIFNMRPIGMTFDRMPLFVWAVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPI |
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-134 | Cytochrome oxidase subunit I profile | ||||
Sequence: RMNNMSFWLLPPSLSLLLMSSLVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSIMGAVNFISTIFNMRPIGMTFDRMPLFVWAVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPI |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length134
- Mass (Da)14,326
- Last updated2001-06-01 v1
- ChecksumC02FB0662A81C883
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: R | ||||||
Non-terminal residue | 134 | |||||
Sequence: I |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF272703 EMBL· GenBank· DDBJ | AAK35005.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360873 EMBL· GenBank· DDBJ | AAL09482.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360874 EMBL· GenBank· DDBJ | AAL09483.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360875 EMBL· GenBank· DDBJ | AAL09484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360876 EMBL· GenBank· DDBJ | AAL09485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360877 EMBL· GenBank· DDBJ | AAL09486.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360878 EMBL· GenBank· DDBJ | AAL09487.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360879 EMBL· GenBank· DDBJ | AAL09488.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360886 EMBL· GenBank· DDBJ | AAL09495.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360887 EMBL· GenBank· DDBJ | AAL09496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360888 EMBL· GenBank· DDBJ | AAL09497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360889 EMBL· GenBank· DDBJ | AAL09498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360890 EMBL· GenBank· DDBJ | AAL09499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360891 EMBL· GenBank· DDBJ | AAL09500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360892 EMBL· GenBank· DDBJ | AAL09501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360893 EMBL· GenBank· DDBJ | AAL09502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360894 EMBL· GenBank· DDBJ | AAL09503.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360895 EMBL· GenBank· DDBJ | AAL09504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360896 EMBL· GenBank· DDBJ | AAL09505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360897 EMBL· GenBank· DDBJ | AAL09506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360898 EMBL· GenBank· DDBJ | AAL09507.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360899 EMBL· GenBank· DDBJ | AAL09508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360900 EMBL· GenBank· DDBJ | AAL09509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360901 EMBL· GenBank· DDBJ | AAL09510.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360902 EMBL· GenBank· DDBJ | AAL09511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360903 EMBL· GenBank· DDBJ | AAL09512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360904 EMBL· GenBank· DDBJ | AAL09513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360905 EMBL· GenBank· DDBJ | AAL09514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360906 EMBL· GenBank· DDBJ | AAL09515.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360907 EMBL· GenBank· DDBJ | AAL09516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360908 EMBL· GenBank· DDBJ | AAL09517.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360909 EMBL· GenBank· DDBJ | AAL09518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360910 EMBL· GenBank· DDBJ | AAL09519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360911 EMBL· GenBank· DDBJ | AAL09520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360912 EMBL· GenBank· DDBJ | AAL09521.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360914 EMBL· GenBank· DDBJ | AAL09523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360915 EMBL· GenBank· DDBJ | AAL09524.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360916 EMBL· GenBank· DDBJ | AAL09525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360917 EMBL· GenBank· DDBJ | AAL09526.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360918 EMBL· GenBank· DDBJ | AAL09527.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360919 EMBL· GenBank· DDBJ | AAL09528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360920 EMBL· GenBank· DDBJ | AAL09529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360921 EMBL· GenBank· DDBJ | AAL09530.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360922 EMBL· GenBank· DDBJ | AAL09531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360923 EMBL· GenBank· DDBJ | AAL09532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360924 EMBL· GenBank· DDBJ | AAL09533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360925 EMBL· GenBank· DDBJ | AAL09534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360926 EMBL· GenBank· DDBJ | AAL09535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360927 EMBL· GenBank· DDBJ | AAL09536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360928 EMBL· GenBank· DDBJ | AAL09537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360929 EMBL· GenBank· DDBJ | AAL09538.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360930 EMBL· GenBank· DDBJ | AAL09539.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360931 EMBL· GenBank· DDBJ | AAL09540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360932 EMBL· GenBank· DDBJ | AAL09541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360933 EMBL· GenBank· DDBJ | AAL09542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360934 EMBL· GenBank· DDBJ | AAL09543.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360935 EMBL· GenBank· DDBJ | AAL09544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360936 EMBL· GenBank· DDBJ | AAL09545.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360937 EMBL· GenBank· DDBJ | AAL09546.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360938 EMBL· GenBank· DDBJ | AAL09547.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360939 EMBL· GenBank· DDBJ | AAL09548.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360940 EMBL· GenBank· DDBJ | AAL09549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360944 EMBL· GenBank· DDBJ | AAL09553.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360946 EMBL· GenBank· DDBJ | AAL09555.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360947 EMBL· GenBank· DDBJ | AAL09556.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360948 EMBL· GenBank· DDBJ | AAL09557.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360949 EMBL· GenBank· DDBJ | AAL09558.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360950 EMBL· GenBank· DDBJ | AAL09559.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360951 EMBL· GenBank· DDBJ | AAL09560.1 EMBL· GenBank· DDBJ | Genomic DNA |