Q9B518 · Q9B518_AQULA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q9B518

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane50-76Helical
Transmembrane88-115Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_501084764829-134Cytochrome c oxidase subunit 1

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-134Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    134
  • Mass (Da)
    14,326
  • Last updated
    2001-06-01 v1
  • Checksum
    C02FB0662A81C883
RMNNMSFWLLPPSLSLLLMSSLVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSIMGAVNFISTIFNMRPIGMTFDRMPLFVWAVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue134

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF272703
EMBL· GenBank· DDBJ
AAK35005.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360873
EMBL· GenBank· DDBJ
AAL09482.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360874
EMBL· GenBank· DDBJ
AAL09483.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360875
EMBL· GenBank· DDBJ
AAL09484.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360876
EMBL· GenBank· DDBJ
AAL09485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360877
EMBL· GenBank· DDBJ
AAL09486.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360878
EMBL· GenBank· DDBJ
AAL09487.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360879
EMBL· GenBank· DDBJ
AAL09488.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360886
EMBL· GenBank· DDBJ
AAL09495.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360887
EMBL· GenBank· DDBJ
AAL09496.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360888
EMBL· GenBank· DDBJ
AAL09497.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360889
EMBL· GenBank· DDBJ
AAL09498.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360890
EMBL· GenBank· DDBJ
AAL09499.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360891
EMBL· GenBank· DDBJ
AAL09500.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360892
EMBL· GenBank· DDBJ
AAL09501.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360893
EMBL· GenBank· DDBJ
AAL09502.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360894
EMBL· GenBank· DDBJ
AAL09503.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360895
EMBL· GenBank· DDBJ
AAL09504.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360896
EMBL· GenBank· DDBJ
AAL09505.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360897
EMBL· GenBank· DDBJ
AAL09506.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360898
EMBL· GenBank· DDBJ
AAL09507.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360899
EMBL· GenBank· DDBJ
AAL09508.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360900
EMBL· GenBank· DDBJ
AAL09509.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360901
EMBL· GenBank· DDBJ
AAL09510.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360902
EMBL· GenBank· DDBJ
AAL09511.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360903
EMBL· GenBank· DDBJ
AAL09512.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360904
EMBL· GenBank· DDBJ
AAL09513.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360905
EMBL· GenBank· DDBJ
AAL09514.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360906
EMBL· GenBank· DDBJ
AAL09515.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360907
EMBL· GenBank· DDBJ
AAL09516.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360908
EMBL· GenBank· DDBJ
AAL09517.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360909
EMBL· GenBank· DDBJ
AAL09518.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360910
EMBL· GenBank· DDBJ
AAL09519.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360911
EMBL· GenBank· DDBJ
AAL09520.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360912
EMBL· GenBank· DDBJ
AAL09521.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360914
EMBL· GenBank· DDBJ
AAL09523.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360915
EMBL· GenBank· DDBJ
AAL09524.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360916
EMBL· GenBank· DDBJ
AAL09525.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360917
EMBL· GenBank· DDBJ
AAL09526.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360918
EMBL· GenBank· DDBJ
AAL09527.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360919
EMBL· GenBank· DDBJ
AAL09528.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360920
EMBL· GenBank· DDBJ
AAL09529.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360921
EMBL· GenBank· DDBJ
AAL09530.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360922
EMBL· GenBank· DDBJ
AAL09531.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360923
EMBL· GenBank· DDBJ
AAL09532.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360924
EMBL· GenBank· DDBJ
AAL09533.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360925
EMBL· GenBank· DDBJ
AAL09534.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360926
EMBL· GenBank· DDBJ
AAL09535.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360927
EMBL· GenBank· DDBJ
AAL09536.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360928
EMBL· GenBank· DDBJ
AAL09537.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360929
EMBL· GenBank· DDBJ
AAL09538.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360930
EMBL· GenBank· DDBJ
AAL09539.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360931
EMBL· GenBank· DDBJ
AAL09540.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360932
EMBL· GenBank· DDBJ
AAL09541.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360933
EMBL· GenBank· DDBJ
AAL09542.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360934
EMBL· GenBank· DDBJ
AAL09543.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360935
EMBL· GenBank· DDBJ
AAL09544.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360936
EMBL· GenBank· DDBJ
AAL09545.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360937
EMBL· GenBank· DDBJ
AAL09546.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360938
EMBL· GenBank· DDBJ
AAL09547.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360939
EMBL· GenBank· DDBJ
AAL09548.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360940
EMBL· GenBank· DDBJ
AAL09549.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360944
EMBL· GenBank· DDBJ
AAL09553.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360946
EMBL· GenBank· DDBJ
AAL09555.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360947
EMBL· GenBank· DDBJ
AAL09556.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360948
EMBL· GenBank· DDBJ
AAL09557.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360949
EMBL· GenBank· DDBJ
AAL09558.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360950
EMBL· GenBank· DDBJ
AAL09559.1
EMBL· GenBank· DDBJ
Genomic DNA
AF360951
EMBL· GenBank· DDBJ
AAL09560.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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