Q9B2Z5 · Q9B2Z5_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9B2Z5
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 84-105 | Helical | ||||
Sequence: YFSMMFIPVALFVTWSIMEFSL | ||||||
Transmembrane | 117-134 | Helical | ||||
Sequence: FFKYLLIFLITMLILVTA | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLISWWYA | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: ILYNRIGDIGFILALAWFIL | ||||||
Transmembrane | 211-233 | Helical | ||||
Sequence: TPLLGLLLAAAGKSAQLGLHPWL | ||||||
Transmembrane | 245-266 | Helical | ||||
Sequence: ALLHSSTMVVAGIFLLIRFHPL | ||||||
Transmembrane | 272-294 | Helical | ||||
Sequence: LIQTLTLCLGAITTLFAAVCALT | ||||||
Transmembrane | 301-319 | Helical | ||||
Sequence: IVAFSTSSQLGLMMVTIGI | ||||||
Transmembrane | 325-347 | Helical | ||||
Sequence: AFLHICTHAFFKAMLFMCSGSII | ||||||
Transmembrane | 368-386 | Helical | ||||
Sequence: LTSTSLTIGSLALAGMPFL | ||||||
Transmembrane | 406-433 | Helical | ||||
Sequence: AWALSITLIATSLTSAYSTRMILLTLTG | ||||||
Transmembrane | 454-472 | Helical | ||||
Sequence: IKRLAAGSLFAGFLITNNI | ||||||
Transmembrane | 484-507 | Helical | ||||
Sequence: LYLKLTALAVTFLGLLTALDLNYL | ||||||
Transmembrane | 584-602 | Helical | ||||
Sequence: IKLYFLSFFFPLILTLLLI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MTMHTTMTTLTLTSLIPPILT | ||||||
Chain | PRO_5015099644 | 22-603 | NADH-ubiquinone oxidoreductase chain 5 | |||
Sequence: TLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPALTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 68-118 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFF | ||||||
Domain | 134-419 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLT | ||||||
Domain | 422-602 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSTRMILLTLTGQPRFPALTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLI |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)66,996
- Last updated2001-06-01 v1
- ChecksumB8B17327A76ED0FD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF346967 EMBL· GenBank· DDBJ | AAK17269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY289052 EMBL· GenBank· DDBJ | AAP47903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY922291 EMBL· GenBank· DDBJ | AAX15456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112731 EMBL· GenBank· DDBJ | AAZ00381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ305010 EMBL· GenBank· DDBJ | ABB99034.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ523636 EMBL· GenBank· DDBJ | ABF48961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF222233 EMBL· GenBank· DDBJ | ABM68672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657390 EMBL· GenBank· DDBJ | ABR95043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095530 EMBL· GenBank· DDBJ | ABU46791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU092895 EMBL· GenBank· DDBJ | ABU67056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU482318 EMBL· GenBank· DDBJ | ACA22069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ147309 EMBL· GenBank· DDBJ | ACH55924.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383760 EMBL· GenBank· DDBJ | ACM77016.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ951570 EMBL· GenBank· DDBJ | ACQ75631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ119030 EMBL· GenBank· DDBJ | ACS48867.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ337562 EMBL· GenBank· DDBJ | ACU09882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ983073 EMBL· GenBank· DDBJ | ACX80676.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM030520 EMBL· GenBank· DDBJ | ADE33348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM185239 EMBL· GenBank· DDBJ | ADK61661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM771231 EMBL· GenBank· DDBJ | ADL16372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012251 EMBL· GenBank· DDBJ | ADM61214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF717355 EMBL· GenBank· DDBJ | AEB98671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824843 EMBL· GenBank· DDBJ | AEG62517.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN655796 EMBL· GenBank· DDBJ | AEQ26695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ044835 EMBL· GenBank· DDBJ | AEV47432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702179 EMBL· GenBank· DDBJ | AFF66295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152785 EMBL· GenBank· DDBJ | AFO20388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX273277 EMBL· GenBank· DDBJ | AFP91646.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX289111 EMBL· GenBank· DDBJ | AFP96195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC505089 EMBL· GenBank· DDBJ | AGI49835.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC622132 EMBL· GenBank· DDBJ | AGJ96198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC533463 EMBL· GenBank· DDBJ | AGK64267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC993929 EMBL· GenBank· DDBJ | AGO22072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF055300 EMBL· GenBank· DDBJ | AGS17401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450846 EMBL· GenBank· DDBJ | AGZ64641.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148278 EMBL· GenBank· DDBJ | AGZ98471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185456 EMBL· GenBank· DDBJ | AID08347.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101608 EMBL· GenBank· DDBJ | AIU57613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457338 EMBL· GenBank· DDBJ | APD64433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408940 EMBL· GenBank· DDBJ | AQU25640.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY083721 EMBL· GenBank· DDBJ | ARB49134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595563 EMBL· GenBank· DDBJ | ARD71953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY671028 EMBL· GenBank· DDBJ | ASC47023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362849 EMBL· GenBank· DDBJ | ASF85741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645581 EMBL· GenBank· DDBJ | ASR13340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF055747 EMBL· GenBank· DDBJ | ASR93646.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680830 EMBL· GenBank· DDBJ | ASZ80889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF621085 EMBL· GenBank· DDBJ | ATP05108.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF696124 EMBL· GenBank· DDBJ | AUT80731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272577 EMBL· GenBank· DDBJ | AVL84931.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG773617 EMBL· GenBank· DDBJ | AWM97050.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008255 EMBL· GenBank· DDBJ | BAE07308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008776 EMBL· GenBank· DDBJ | BAE14083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010707 EMBL· GenBank· DDBJ | BAG15001.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009428 EMBL· GenBank· DDBJ | BAG38834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687241 EMBL· GenBank· DDBJ | QLH91971.1 EMBL· GenBank· DDBJ | Genomic DNA |