Q9B2Z5 · Q9B2Z5_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    ND5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5
    • Synonyms
      NADH5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MTDNA242
    • Aus14
    • GCsq0019
    • NDsq0116
    • Mdmd10
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9B2Z5

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane211-233Helical
Transmembrane245-266Helical
Transmembrane272-294Helical
Transmembrane301-319Helical
Transmembrane325-347Helical
Transmembrane368-386Helical
Transmembrane406-433Helical
Transmembrane454-472Helical
Transmembrane484-507Helical
Transmembrane584-602Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_501509964422-603NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-602NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    66,996
  • Last updated
    2001-06-01 v1
  • Checksum
    B8B17327A76ED0FD
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPALTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF346967
EMBL· GenBank· DDBJ
AAK17269.1
EMBL· GenBank· DDBJ
Genomic DNA
AY289052
EMBL· GenBank· DDBJ
AAP47903.1
EMBL· GenBank· DDBJ
Genomic DNA
AY922291
EMBL· GenBank· DDBJ
AAX15456.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112731
EMBL· GenBank· DDBJ
AAZ00381.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ305010
EMBL· GenBank· DDBJ
ABB99034.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ523636
EMBL· GenBank· DDBJ
ABF48961.1
EMBL· GenBank· DDBJ
Genomic DNA
EF222233
EMBL· GenBank· DDBJ
ABM68672.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657390
EMBL· GenBank· DDBJ
ABR95043.1
EMBL· GenBank· DDBJ
Genomic DNA
EU095530
EMBL· GenBank· DDBJ
ABU46791.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092895
EMBL· GenBank· DDBJ
ABU67056.1
EMBL· GenBank· DDBJ
Genomic DNA
EU482318
EMBL· GenBank· DDBJ
ACA22069.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ147309
EMBL· GenBank· DDBJ
ACH55924.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383760
EMBL· GenBank· DDBJ
ACM77016.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ951570
EMBL· GenBank· DDBJ
ACQ75631.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ119030
EMBL· GenBank· DDBJ
ACS48867.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ337562
EMBL· GenBank· DDBJ
ACU09882.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ983073
EMBL· GenBank· DDBJ
ACX80676.1
EMBL· GenBank· DDBJ
Genomic DNA
HM030520
EMBL· GenBank· DDBJ
ADE33348.1
EMBL· GenBank· DDBJ
Genomic DNA
HM185239
EMBL· GenBank· DDBJ
ADK61661.1
EMBL· GenBank· DDBJ
Genomic DNA
HM771231
EMBL· GenBank· DDBJ
ADL16372.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012251
EMBL· GenBank· DDBJ
ADM61214.1
EMBL· GenBank· DDBJ
Genomic DNA
JF717355
EMBL· GenBank· DDBJ
AEB98671.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824843
EMBL· GenBank· DDBJ
AEG62517.1
EMBL· GenBank· DDBJ
Genomic DNA
JN655796
EMBL· GenBank· DDBJ
AEQ26695.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ044835
EMBL· GenBank· DDBJ
AEV47432.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702179
EMBL· GenBank· DDBJ
AFF66295.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152785
EMBL· GenBank· DDBJ
AFO20388.1
EMBL· GenBank· DDBJ
Genomic DNA
JX273277
EMBL· GenBank· DDBJ
AFP91646.1
EMBL· GenBank· DDBJ
Genomic DNA
JX289111
EMBL· GenBank· DDBJ
AFP96195.1
EMBL· GenBank· DDBJ
Genomic DNA
KC505089
EMBL· GenBank· DDBJ
AGI49835.1
EMBL· GenBank· DDBJ
Genomic DNA
KC622132
EMBL· GenBank· DDBJ
AGJ96198.1
EMBL· GenBank· DDBJ
Genomic DNA
KC533463
EMBL· GenBank· DDBJ
AGK64267.1
EMBL· GenBank· DDBJ
Genomic DNA
KC993929
EMBL· GenBank· DDBJ
AGO22072.1
EMBL· GenBank· DDBJ
Genomic DNA
KF055300
EMBL· GenBank· DDBJ
AGS17401.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450846
EMBL· GenBank· DDBJ
AGZ64641.1
EMBL· GenBank· DDBJ
Genomic DNA
KF148278
EMBL· GenBank· DDBJ
AGZ98471.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185456
EMBL· GenBank· DDBJ
AID08347.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101608
EMBL· GenBank· DDBJ
AIU57613.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457338
EMBL· GenBank· DDBJ
APD64433.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408940
EMBL· GenBank· DDBJ
AQU25640.1
EMBL· GenBank· DDBJ
Genomic DNA
KY083721
EMBL· GenBank· DDBJ
ARB49134.1
EMBL· GenBank· DDBJ
Genomic DNA
KY595563
EMBL· GenBank· DDBJ
ARD71953.1
EMBL· GenBank· DDBJ
Genomic DNA
KY671028
EMBL· GenBank· DDBJ
ASC47023.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362849
EMBL· GenBank· DDBJ
ASF85741.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645581
EMBL· GenBank· DDBJ
ASR13340.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055747
EMBL· GenBank· DDBJ
ASR93646.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680830
EMBL· GenBank· DDBJ
ASZ80889.1
EMBL· GenBank· DDBJ
Genomic DNA
MF621085
EMBL· GenBank· DDBJ
ATP05108.1
EMBL· GenBank· DDBJ
Genomic DNA
MF696124
EMBL· GenBank· DDBJ
AUT80731.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272577
EMBL· GenBank· DDBJ
AVL84931.1
EMBL· GenBank· DDBJ
Genomic DNA
MG773617
EMBL· GenBank· DDBJ
AWM97050.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008255
EMBL· GenBank· DDBJ
BAE07308.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008776
EMBL· GenBank· DDBJ
BAE14083.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010707
EMBL· GenBank· DDBJ
BAG15001.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009428
EMBL· GenBank· DDBJ
BAG38834.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687241
EMBL· GenBank· DDBJ
QLH91971.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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