Q9B2Z3 · Q9B2Z3_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 2
  • Gene
    ND2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number

Gene names

    • Name
      ND2
    • Synonyms
      NADH2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 129
    • MTDNA112
    • WH6954
    • ONsq0002
    • TCsq0006
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9B2Z3
  • Secondary accessions
    • D2ITP2
    • Q85KY7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane56-76Helical
Transmembrane96-115Helical
Transmembrane151-171Helical
Transmembrane178-196Helical
Transmembrane202-219Helical
Transmembrane239-257Helical
Transmembrane277-305Helical
Transmembrane325-346Helical

Keywords

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-284NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain290-344NADH dehydrogenase subunit 2 C-terminal

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    38,931
  • Last updated
    2001-06-01 v1
  • Checksum
    2AC573289CD74F30
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVAQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF346971
EMBL· GenBank· DDBJ
AAK17312.1
EMBL· GenBank· DDBJ
Genomic DNA
AF382010
EMBL· GenBank· DDBJ
AAL54762.1
EMBL· GenBank· DDBJ
Genomic DNA
AY255144
EMBL· GenBank· DDBJ
AAO66762.1
EMBL· GenBank· DDBJ
Genomic DNA
AY195760
EMBL· GenBank· DDBJ
AAO88476.2
EMBL· GenBank· DDBJ
Genomic DNA
AY195771
EMBL· GenBank· DDBJ
AAO88619.1
EMBL· GenBank· DDBJ
Genomic DNA
AY519486
EMBL· GenBank· DDBJ
AAR91233.1
EMBL· GenBank· DDBJ
Genomic DNA
AY963575
EMBL· GenBank· DDBJ
AAX53712.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112695
EMBL· GenBank· DDBJ
AAY99904.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ272123
EMBL· GenBank· DDBJ
ABB51451.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ282387
EMBL· GenBank· DDBJ
ABB78092.1
EMBL· GenBank· DDBJ
Genomic DNA
EF079873
EMBL· GenBank· DDBJ
ABK28792.1
EMBL· GenBank· DDBJ
Genomic DNA
EF153771
EMBL· GenBank· DDBJ
ABL60021.1
EMBL· GenBank· DDBJ
Genomic DNA
EF114279
EMBL· GenBank· DDBJ
ABO36914.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657246
EMBL· GenBank· DDBJ
ABR93167.1
EMBL· GenBank· DDBJ
Genomic DNA
EU007836
EMBL· GenBank· DDBJ
ABS57695.1
EMBL· GenBank· DDBJ
Genomic DNA
EU095526
EMBL· GenBank· DDBJ
ABU46730.1
EMBL· GenBank· DDBJ
Genomic DNA
EU095194
EMBL· GenBank· DDBJ
ABU47081.1
EMBL· GenBank· DDBJ
Genomic DNA
EU273499
EMBL· GenBank· DDBJ
ABX40341.1
EMBL· GenBank· DDBJ
Genomic DNA
EU482338
EMBL· GenBank· DDBJ
ACA22320.1
EMBL· GenBank· DDBJ
Genomic DNA
EU725607
EMBL· GenBank· DDBJ
ACD76447.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ544232
EMBL· GenBank· DDBJ
ACK76893.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ748705
EMBL· GenBank· DDBJ
ACN37130.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ129164
EMBL· GenBank· DDBJ
ACR09075.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398480
EMBL· GenBank· DDBJ
ACT88835.2
EMBL· GenBank· DDBJ
Genomic DNA
GQ398481
EMBL· GenBank· DDBJ
ACT88848.2
EMBL· GenBank· DDBJ
Genomic DNA
GQ999962
EMBL· GenBank· DDBJ
ACX49192.1
EMBL· GenBank· DDBJ
Genomic DNA
GU122995
EMBL· GenBank· DDBJ
ACY55336.1
EMBL· GenBank· DDBJ
Genomic DNA
GU377085
EMBL· GenBank· DDBJ
ADB78187.1
EMBL· GenBank· DDBJ
Genomic DNA
HM771125
EMBL· GenBank· DDBJ
ADL14985.1
EMBL· GenBank· DDBJ
Genomic DNA
HM852848
EMBL· GenBank· DDBJ
ADL31091.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012049
EMBL· GenBank· DDBJ
ADM58579.1
EMBL· GenBank· DDBJ
Genomic DNA
GU392057
EMBL· GenBank· DDBJ
ADN41797.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ287872
EMBL· GenBank· DDBJ
ADO50682.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ713443
EMBL· GenBank· DDBJ
ADW26235.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824891
EMBL· GenBank· DDBJ
AEG63132.1
EMBL· GenBank· DDBJ
Genomic DNA
JN580301
EMBL· GenBank· DDBJ
AEO89795.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701855
EMBL· GenBank· DDBJ
AFF62074.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ965970
EMBL· GenBank· DDBJ
AFK75534.1
EMBL· GenBank· DDBJ
Genomic DNA
JX266267
EMBL· GenBank· DDBJ
AFP91149.1
EMBL· GenBank· DDBJ
Genomic DNA
KC257400
EMBL· GenBank· DDBJ
AGE02561.1
EMBL· GenBank· DDBJ
Genomic DNA
KC503930
EMBL· GenBank· DDBJ
AGH18635.1
EMBL· GenBank· DDBJ
Genomic DNA
KC711008
EMBL· GenBank· DDBJ
AGL44579.1
EMBL· GenBank· DDBJ
Genomic DNA
KC994087
EMBL· GenBank· DDBJ
AGO24117.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911275
EMBL· GenBank· DDBJ
AGO90316.1
EMBL· GenBank· DDBJ
Genomic DNA
KC998702
EMBL· GenBank· DDBJ
AGQ46070.1
EMBL· GenBank· DDBJ
Genomic DNA
KF056302
EMBL· GenBank· DDBJ
AGT53114.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252459
EMBL· GenBank· DDBJ
AGX91345.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540613
EMBL· GenBank· DDBJ
AGZ07262.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451225
EMBL· GenBank· DDBJ
AGZ69559.1
EMBL· GenBank· DDBJ
Genomic DNA
KF148096
EMBL· GenBank· DDBJ
AGZ96096.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849904
EMBL· GenBank· DDBJ
AHE78641.1
EMBL· GenBank· DDBJ
Genomic DNA
KF874330
EMBL· GenBank· DDBJ
AHH00023.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ735671
EMBL· GenBank· DDBJ
AIH01035.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ923807
EMBL· GenBank· DDBJ
AIJ18420.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ801465
EMBL· GenBank· DDBJ
AIL91904.1
EMBL· GenBank· DDBJ
Genomic DNA
KM051467
EMBL· GenBank· DDBJ
AIS38022.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101623
EMBL· GenBank· DDBJ
AIU57799.1
EMBL· GenBank· DDBJ
Genomic DNA
KM656458
EMBL· GenBank· DDBJ
AJO61456.1
EMBL· GenBank· DDBJ
Genomic DNA
KP300790
EMBL· GenBank· DDBJ
AKG64505.1
EMBL· GenBank· DDBJ
Genomic DNA
KT213744
EMBL· GenBank· DDBJ
ALQ78920.1
EMBL· GenBank· DDBJ
Genomic DNA
KU521437
EMBL· GenBank· DDBJ
AMK46788.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725873
EMBL· GenBank· DDBJ
ANA92155.1
EMBL· GenBank· DDBJ
Genomic DNA
KX228170
EMBL· GenBank· DDBJ
ANP95155.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456444
EMBL· GenBank· DDBJ
APD52803.1
EMBL· GenBank· DDBJ
Genomic DNA
KX675310
EMBL· GenBank· DDBJ
APZ83727.1
EMBL· GenBank· DDBJ
Genomic DNA
KY399179
EMBL· GenBank· DDBJ
AQU13545.1
EMBL· GenBank· DDBJ
Genomic DNA
KX977308
EMBL· GenBank· DDBJ
AQZ25268.1
EMBL· GenBank· DDBJ
Genomic DNA
KY083705
EMBL· GenBank· DDBJ
ARB48917.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782204
EMBL· GenBank· DDBJ
ASC43772.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645512
EMBL· GenBank· DDBJ
ASR12434.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056689
EMBL· GenBank· DDBJ
ASS05885.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680794
EMBL· GenBank· DDBJ
ASZ80412.1
EMBL· GenBank· DDBJ
Genomic DNA
MF588800
EMBL· GenBank· DDBJ
ATI23801.1
EMBL· GenBank· DDBJ
Genomic DNA
MF043437
EMBL· GenBank· DDBJ
ATP01675.1
EMBL· GenBank· DDBJ
Genomic DNA
KY797225
EMBL· GenBank· DDBJ
AUG83062.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272631
EMBL· GenBank· DDBJ
AVL85624.1
EMBL· GenBank· DDBJ
Genomic DNA
MH448948
EMBL· GenBank· DDBJ
AYW04037.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981825
EMBL· GenBank· DDBJ
AZJ13696.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008265
EMBL· GenBank· DDBJ
BAE07429.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008538
EMBL· GenBank· DDBJ
BAE10980.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010675
EMBL· GenBank· DDBJ
BAG14576.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009429
EMBL· GenBank· DDBJ
BAG38838.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010832
EMBL· GenBank· DDBJ
BAH11003.1
EMBL· GenBank· DDBJ
Genomic DNA
LC198226
EMBL· GenBank· DDBJ
BAX73911.1
EMBL· GenBank· DDBJ
Genomic DNA
MH499869
EMBL· GenBank· DDBJ
QBX96085.1
EMBL· GenBank· DDBJ
Genomic DNA
MG778662
EMBL· GenBank· DDBJ
QEU53401.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419078
EMBL· GenBank· DDBJ
QMP92536.1
EMBL· GenBank· DDBJ
Genomic DNA
MT742581
EMBL· GenBank· DDBJ
QOH99756.1
EMBL· GenBank· DDBJ
Genomic DNA
MK795840
EMBL· GenBank· DDBJ
QQP22732.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857261
EMBL· GenBank· DDBJ
QTK13949.1
EMBL· GenBank· DDBJ
Genomic DNA
MW467806
EMBL· GenBank· DDBJ
QTK29386.1
EMBL· GenBank· DDBJ
Genomic DNA
MW886121
EMBL· GenBank· DDBJ
QUL59137.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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