Q9B2Z3 · Q9B2Z3_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 2
- GeneND2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids347 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 2
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9B2Z3
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 56-76 | Helical | ||||
Sequence: AIKYFLTQATASMILLMAILF | ||||||
Transmembrane | 96-115 | Helical | ||||
Sequence: LMIMMAMAMKLGMAPFHFWV | ||||||
Transmembrane | 151-171 | Helical | ||||
Sequence: VSLLLTLSILSIMAGSWGGLN | ||||||
Transmembrane | 178-196 | Helical | ||||
Sequence: ILAYSSITHMGWMMAVLPY | ||||||
Transmembrane | 202-219 | Helical | ||||
Sequence: ILNLTIYIILTTTAFLLL | ||||||
Transmembrane | 239-257 | Helical | ||||
Sequence: WLTPLIPSTLLSLGGLPPL | ||||||
Transmembrane | 277-305 | Helical | ||||
Sequence: IIPTIMATITLLNLYFYLRLIYSTSITLL | ||||||
Transmembrane | 325-346 | Helical | ||||
Sequence: FLPTLIALTTLLLPISPFMLMI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-284 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: SSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVAQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMAT | ||||||
Domain | 290-344 | NADH dehydrogenase subunit 2 C-terminal | ||||
Sequence: LYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFML |
Sequence similarities
Belongs to the complex I subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)38,931
- Last updated2001-06-01 v1
- Checksum2AC573289CD74F30
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF346971 EMBL· GenBank· DDBJ | AAK17312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF382010 EMBL· GenBank· DDBJ | AAL54762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY255144 EMBL· GenBank· DDBJ | AAO66762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195760 EMBL· GenBank· DDBJ | AAO88476.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195771 EMBL· GenBank· DDBJ | AAO88619.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY519486 EMBL· GenBank· DDBJ | AAR91233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY963575 EMBL· GenBank· DDBJ | AAX53712.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112695 EMBL· GenBank· DDBJ | AAY99904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ272123 EMBL· GenBank· DDBJ | ABB51451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282387 EMBL· GenBank· DDBJ | ABB78092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF079873 EMBL· GenBank· DDBJ | ABK28792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF153771 EMBL· GenBank· DDBJ | ABL60021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF114279 EMBL· GenBank· DDBJ | ABO36914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657246 EMBL· GenBank· DDBJ | ABR93167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU007836 EMBL· GenBank· DDBJ | ABS57695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095526 EMBL· GenBank· DDBJ | ABU46730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095194 EMBL· GenBank· DDBJ | ABU47081.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU273499 EMBL· GenBank· DDBJ | ABX40341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU482338 EMBL· GenBank· DDBJ | ACA22320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU725607 EMBL· GenBank· DDBJ | ACD76447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ544232 EMBL· GenBank· DDBJ | ACK76893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ748705 EMBL· GenBank· DDBJ | ACN37130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ129164 EMBL· GenBank· DDBJ | ACR09075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398480 EMBL· GenBank· DDBJ | ACT88835.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398481 EMBL· GenBank· DDBJ | ACT88848.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ999962 EMBL· GenBank· DDBJ | ACX49192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU122995 EMBL· GenBank· DDBJ | ACY55336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU377085 EMBL· GenBank· DDBJ | ADB78187.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM771125 EMBL· GenBank· DDBJ | ADL14985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852848 EMBL· GenBank· DDBJ | ADL31091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012049 EMBL· GenBank· DDBJ | ADM58579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU392057 EMBL· GenBank· DDBJ | ADN41797.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ287872 EMBL· GenBank· DDBJ | ADO50682.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ713443 EMBL· GenBank· DDBJ | ADW26235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824891 EMBL· GenBank· DDBJ | AEG63132.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN580301 EMBL· GenBank· DDBJ | AEO89795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701855 EMBL· GenBank· DDBJ | AFF62074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ965970 EMBL· GenBank· DDBJ | AFK75534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX266267 EMBL· GenBank· DDBJ | AFP91149.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC257400 EMBL· GenBank· DDBJ | AGE02561.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC503930 EMBL· GenBank· DDBJ | AGH18635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC711008 EMBL· GenBank· DDBJ | AGL44579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC994087 EMBL· GenBank· DDBJ | AGO24117.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911275 EMBL· GenBank· DDBJ | AGO90316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC998702 EMBL· GenBank· DDBJ | AGQ46070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF056302 EMBL· GenBank· DDBJ | AGT53114.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252459 EMBL· GenBank· DDBJ | AGX91345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540613 EMBL· GenBank· DDBJ | AGZ07262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451225 EMBL· GenBank· DDBJ | AGZ69559.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148096 EMBL· GenBank· DDBJ | AGZ96096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849904 EMBL· GenBank· DDBJ | AHE78641.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF874330 EMBL· GenBank· DDBJ | AHH00023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ735671 EMBL· GenBank· DDBJ | AIH01035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ923807 EMBL· GenBank· DDBJ | AIJ18420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ801465 EMBL· GenBank· DDBJ | AIL91904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM051467 EMBL· GenBank· DDBJ | AIS38022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101623 EMBL· GenBank· DDBJ | AIU57799.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM656458 EMBL· GenBank· DDBJ | AJO61456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP300790 EMBL· GenBank· DDBJ | AKG64505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT213744 EMBL· GenBank· DDBJ | ALQ78920.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU521437 EMBL· GenBank· DDBJ | AMK46788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725873 EMBL· GenBank· DDBJ | ANA92155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX228170 EMBL· GenBank· DDBJ | ANP95155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456444 EMBL· GenBank· DDBJ | APD52803.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675310 EMBL· GenBank· DDBJ | APZ83727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY399179 EMBL· GenBank· DDBJ | AQU13545.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX977308 EMBL· GenBank· DDBJ | AQZ25268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY083705 EMBL· GenBank· DDBJ | ARB48917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782204 EMBL· GenBank· DDBJ | ASC43772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645512 EMBL· GenBank· DDBJ | ASR12434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056689 EMBL· GenBank· DDBJ | ASS05885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680794 EMBL· GenBank· DDBJ | ASZ80412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF588800 EMBL· GenBank· DDBJ | ATI23801.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF043437 EMBL· GenBank· DDBJ | ATP01675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY797225 EMBL· GenBank· DDBJ | AUG83062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272631 EMBL· GenBank· DDBJ | AVL85624.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH448948 EMBL· GenBank· DDBJ | AYW04037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981825 EMBL· GenBank· DDBJ | AZJ13696.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008265 EMBL· GenBank· DDBJ | BAE07429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008538 EMBL· GenBank· DDBJ | BAE10980.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010675 EMBL· GenBank· DDBJ | BAG14576.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009429 EMBL· GenBank· DDBJ | BAG38838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010832 EMBL· GenBank· DDBJ | BAH11003.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC198226 EMBL· GenBank· DDBJ | BAX73911.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH499869 EMBL· GenBank· DDBJ | QBX96085.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG778662 EMBL· GenBank· DDBJ | QEU53401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419078 EMBL· GenBank· DDBJ | QMP92536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT742581 EMBL· GenBank· DDBJ | QOH99756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK795840 EMBL· GenBank· DDBJ | QQP22732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857261 EMBL· GenBank· DDBJ | QTK13949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW467806 EMBL· GenBank· DDBJ | QTK29386.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW886121 EMBL· GenBank· DDBJ | QUL59137.1 EMBL· GenBank· DDBJ | Genomic DNA |