Q9B2Z1 · Q9B2Z1_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 4L
- GeneND4L
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)This reaction proceeds in the forward direction.
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4L
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9B2Z1
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-22 | Helical | ||||
Sequence: MNIMLAFTISLLGMLVY | ||||||
Transmembrane | 29-49 | Helical | ||||
Sequence: SLLCLEGMMLSLFIMATLTTL | ||||||
Transmembrane | 55-79 | Helical | ||||
Sequence: LANIVPIAMLVFAACEAAVGLALLV |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Sequence
- Sequence statusComplete
- Length98
- Mass (Da)10,711
- Last updated2001-06-01 v1
- Checksum24B91F0E500676D2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF346971 EMBL· GenBank· DDBJ | AAK17319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY063376 EMBL· GenBank· DDBJ | AAL48358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY255164 EMBL· GenBank· DDBJ | AAO67029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195791 EMBL· GenBank· DDBJ | AAO88886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY289099 EMBL· GenBank· DDBJ | AAP48511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY950289 EMBL· GenBank· DDBJ | AAX47805.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY963572 EMBL· GenBank· DDBJ | AAX53680.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ272124 EMBL· GenBank· DDBJ | ABB51471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF114270 EMBL· GenBank· DDBJ | ABO36804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657682 EMBL· GenBank· DDBJ | ABR98832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU007894 EMBL· GenBank· DDBJ | ABS58456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU482358 EMBL· GenBank· DDBJ | ACA22587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ198214 EMBL· GenBank· DDBJ | ACI04272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ748713 EMBL· GenBank· DDBJ | ACN37241.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ770967 EMBL· GenBank· DDBJ | ACN49845.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ119028 EMBL· GenBank· DDBJ | ACS48839.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ301863 EMBL· GenBank· DDBJ | ACT15641.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU377084 EMBL· GenBank· DDBJ | ADB78181.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM357814 EMBL· GenBank· DDBJ | ADI79466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852794 EMBL· GenBank· DDBJ | ADL30396.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM596654 EMBL· GenBank· DDBJ | ADN10975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU392054 EMBL· GenBank· DDBJ | ADN41765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU733782 EMBL· GenBank· DDBJ | ADP23188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM238199 EMBL· GenBank· DDBJ | ADV35182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ700871 EMBL· GenBank· DDBJ | ADV38755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ713444 EMBL· GenBank· DDBJ | ADW26255.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF739536 EMBL· GenBank· DDBJ | AEE60375.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824884 EMBL· GenBank· DDBJ | AEG63048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN133516 EMBL· GenBank· DDBJ | AEK66608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702074 EMBL· GenBank· DDBJ | AFF64928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX024566 EMBL· GenBank· DDBJ | AFK80783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153089 EMBL· GenBank· DDBJ | AFO24338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC505083 EMBL· GenBank· DDBJ | AGI49755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC733252 EMBL· GenBank· DDBJ | AGL11388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC993912 EMBL· GenBank· DDBJ | AGO21849.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911336 EMBL· GenBank· DDBJ | AGO91116.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF056261 EMBL· GenBank· DDBJ | AGT52588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252363 EMBL· GenBank· DDBJ | AGX90104.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540547 EMBL· GenBank· DDBJ | AGZ06411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450880 EMBL· GenBank· DDBJ | AGZ65081.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148087 EMBL· GenBank· DDBJ | AGZ95986.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849920 EMBL· GenBank· DDBJ | AHE78856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101607 EMBL· GenBank· DDBJ | AIU57598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP346026 EMBL· GenBank· DDBJ | AKC00071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP340146 EMBL· GenBank· DDBJ | AKH35522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU521498 EMBL· GenBank· DDBJ | AMK47588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725898 EMBL· GenBank· DDBJ | ANA92486.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX228162 EMBL· GenBank· DDBJ | ANP95058.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456435 EMBL· GenBank· DDBJ | APD52693.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675303 EMBL· GenBank· DDBJ | APZ83643.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF043438 EMBL· GenBank· DDBJ | ATP01695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF695990 EMBL· GenBank· DDBJ | AUT78987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272585 EMBL· GenBank· DDBJ | AVL85033.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH359195 EMBL· GenBank· DDBJ | AWV63671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981651 EMBL· GenBank· DDBJ | AYV90675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH448949 EMBL· GenBank· DDBJ | AYW04057.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008279 EMBL· GenBank· DDBJ | BAE07618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008577 EMBL· GenBank· DDBJ | BAE11494.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010664 EMBL· GenBank· DDBJ | BAG14440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009440 EMBL· GenBank· DDBJ | BAG38988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010837 EMBL· GenBank· DDBJ | BAH11075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP012388 EMBL· GenBank· DDBJ | BAM25624.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128801 EMBL· GenBank· DDBJ | QBB87309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH499873 EMBL· GenBank· DDBJ | QBX96144.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG778671 EMBL· GenBank· DDBJ | QEU53525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT418944 EMBL· GenBank· DDBJ | QMP90801.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT506309 EMBL· GenBank· DDBJ | QPF98784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK795832 EMBL· GenBank· DDBJ | QQP22635.1 EMBL· GenBank· DDBJ | Genomic DNA |