Q9B2U8 · Q9B2U8_HUMAN

  • Protein
    Cytochrome c oxidase subunit 2
  • Gene
    COX2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological Processelectron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COX2
    • Synonyms
      COII
      , coxII

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C22
    • HNsq0191
    • KAsq0057
    • ONsq0136
    • PDsq0032
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9B2U8

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-46Helical
Transmembrane66-85Helical

Keywords

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-91Cytochrome oxidase subunit II transmembrane region profile
Domain92-225Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    25,551
  • Last updated
    2001-06-01 v1
  • Checksum
    799836363CB4FF7C
MAHAAQVGLQDATSPIMEELITFHDHALMVIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF347008
EMBL· GenBank· DDBJ
AAK17795.1
EMBL· GenBank· DDBJ
Genomic DNA
AY714004
EMBL· GenBank· DDBJ
AAU02491.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112879
EMBL· GenBank· DDBJ
AAZ02298.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ246818
EMBL· GenBank· DDBJ
ABB45497.1
EMBL· GenBank· DDBJ
Genomic DNA
EF093554
EMBL· GenBank· DDBJ
ABL61830.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ119008
EMBL· GenBank· DDBJ
ACS48574.1
EMBL· GenBank· DDBJ
Genomic DNA
JN655781
EMBL· GenBank· DDBJ
AEQ26493.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702268
EMBL· GenBank· DDBJ
AFF67445.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ798080
EMBL· GenBank· DDBJ
AFI53791.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346162
EMBL· GenBank· DDBJ
AGD87064.1
EMBL· GenBank· DDBJ
Genomic DNA
KC733262
EMBL· GenBank· DDBJ
AGL11513.1
EMBL· GenBank· DDBJ
Genomic DNA
KC733263
EMBL· GenBank· DDBJ
AGL11526.2
EMBL· GenBank· DDBJ
Genomic DNA
KC733264
EMBL· GenBank· DDBJ
AGL11539.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451807
EMBL· GenBank· DDBJ
AGZ77127.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898135
EMBL· GenBank· DDBJ
AHI96055.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898137
EMBL· GenBank· DDBJ
AHI96081.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898138
EMBL· GenBank· DDBJ
AHI96094.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898139
EMBL· GenBank· DDBJ
AHI96107.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898140
EMBL· GenBank· DDBJ
AHI96120.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898142
EMBL· GenBank· DDBJ
AHI96146.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898143
EMBL· GenBank· DDBJ
AHI96159.1
EMBL· GenBank· DDBJ
Genomic DNA
KF898144
EMBL· GenBank· DDBJ
AHI96172.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446608
EMBL· GenBank· DDBJ
AHX53961.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ856734
EMBL· GenBank· DDBJ
AIN38038.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ856776
EMBL· GenBank· DDBJ
AIN38584.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725882
EMBL· GenBank· DDBJ
ANA92273.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725891
EMBL· GenBank· DDBJ
ANA92390.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725907
EMBL· GenBank· DDBJ
ANA92598.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725908
EMBL· GenBank· DDBJ
ANA92611.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725909
EMBL· GenBank· DDBJ
ANA92624.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725930
EMBL· GenBank· DDBJ
ANA92895.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725956
EMBL· GenBank· DDBJ
ANA93231.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056584
EMBL· GenBank· DDBJ
ASS04522.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272585
EMBL· GenBank· DDBJ
AVL85028.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272698
EMBL· GenBank· DDBJ
AVL86497.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272699
EMBL· GenBank· DDBJ
AVL86510.1
EMBL· GenBank· DDBJ
Genomic DNA
MH120553
EMBL· GenBank· DDBJ
AZJ09794.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981837
EMBL· GenBank· DDBJ
AZJ13854.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008370
EMBL· GenBank· DDBJ
BAE08796.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008495
EMBL· GenBank· DDBJ
BAE10421.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008623
EMBL· GenBank· DDBJ
BAE12087.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008678
EMBL· GenBank· DDBJ
BAE12802.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009422
EMBL· GenBank· DDBJ
BAG38749.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013218
EMBL· GenBank· DDBJ
BAN80673.1
EMBL· GenBank· DDBJ
Genomic DNA
MH553792
EMBL· GenBank· DDBJ
QBY38194.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437126
EMBL· GenBank· DDBJ
QBZ74875.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059598
EMBL· GenBank· DDBJ
QCB17985.1
EMBL· GenBank· DDBJ
Genomic DNA
MN628065
EMBL· GenBank· DDBJ
QXO91410.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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