Q9B2U8 · Q9B2U8_HUMAN
- ProteinCytochrome c oxidase subunit 2
- GeneCOX2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Note: Binds a copper A center.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Biological Process | electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 2
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9B2U8
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 27-46 | Helical | |||
Transmembrane | 66-85 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-91 | Cytochrome oxidase subunit II transmembrane region profile | |||
Domain | 92-225 | Cytochrome oxidase subunit II copper A binding | |||
Sequence similarities
Belongs to the cytochrome c oxidase subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)25,551
- Last updated2001-06-01 v1
- Checksum799836363CB4FF7C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF347008 EMBL· GenBank· DDBJ | AAK17795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY714004 EMBL· GenBank· DDBJ | AAU02491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112879 EMBL· GenBank· DDBJ | AAZ02298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ246818 EMBL· GenBank· DDBJ | ABB45497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF093554 EMBL· GenBank· DDBJ | ABL61830.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ119008 EMBL· GenBank· DDBJ | ACS48574.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN655781 EMBL· GenBank· DDBJ | AEQ26493.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702268 EMBL· GenBank· DDBJ | AFF67445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ798080 EMBL· GenBank· DDBJ | AFI53791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC346162 EMBL· GenBank· DDBJ | AGD87064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC733262 EMBL· GenBank· DDBJ | AGL11513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC733263 EMBL· GenBank· DDBJ | AGL11526.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC733264 EMBL· GenBank· DDBJ | AGL11539.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451807 EMBL· GenBank· DDBJ | AGZ77127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898135 EMBL· GenBank· DDBJ | AHI96055.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898137 EMBL· GenBank· DDBJ | AHI96081.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898138 EMBL· GenBank· DDBJ | AHI96094.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898139 EMBL· GenBank· DDBJ | AHI96107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898140 EMBL· GenBank· DDBJ | AHI96120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898142 EMBL· GenBank· DDBJ | AHI96146.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898143 EMBL· GenBank· DDBJ | AHI96159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF898144 EMBL· GenBank· DDBJ | AHI96172.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446608 EMBL· GenBank· DDBJ | AHX53961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ856734 EMBL· GenBank· DDBJ | AIN38038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ856776 EMBL· GenBank· DDBJ | AIN38584.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725882 EMBL· GenBank· DDBJ | ANA92273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725891 EMBL· GenBank· DDBJ | ANA92390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725907 EMBL· GenBank· DDBJ | ANA92598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725908 EMBL· GenBank· DDBJ | ANA92611.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725909 EMBL· GenBank· DDBJ | ANA92624.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725930 EMBL· GenBank· DDBJ | ANA92895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725956 EMBL· GenBank· DDBJ | ANA93231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056584 EMBL· GenBank· DDBJ | ASS04522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272585 EMBL· GenBank· DDBJ | AVL85028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272698 EMBL· GenBank· DDBJ | AVL86497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272699 EMBL· GenBank· DDBJ | AVL86510.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH120553 EMBL· GenBank· DDBJ | AZJ09794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981837 EMBL· GenBank· DDBJ | AZJ13854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008370 EMBL· GenBank· DDBJ | BAE08796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008495 EMBL· GenBank· DDBJ | BAE10421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008623 EMBL· GenBank· DDBJ | BAE12087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008678 EMBL· GenBank· DDBJ | BAE12802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009422 EMBL· GenBank· DDBJ | BAG38749.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013218 EMBL· GenBank· DDBJ | BAN80673.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553792 EMBL· GenBank· DDBJ | QBY38194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437126 EMBL· GenBank· DDBJ | QBZ74875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059598 EMBL· GenBank· DDBJ | QCB17985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN628065 EMBL· GenBank· DDBJ | QXO91410.1 EMBL· GenBank· DDBJ | Genomic DNA |