Q9B2U6 · Q9B2U6_HUMAN

  • Protein
    Cytochrome c oxidase subunit 3
  • Gene
    COX3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      COX3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MTDNA157
    • Aleut I-1
    • Aleut I-10
    • Aleut I-11
    • Aleut I-12
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9B2U6

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-35Helical
Transmembrane41-58Helical
Transmembrane79-102Helical
Transmembrane159-177Helical
Transmembrane197-220Helical
Transmembrane240-259Helical

Keywords

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-260Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    260
  • Mass (Da)
    29,837
  • Last updated
    2001-06-01 v1
  • Checksum
    D1CCC4E529F63C2A
MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMESNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF347010
EMBL· GenBank· DDBJ
AAK17824.2
EMBL· GenBank· DDBJ
Genomic DNA
AF381997
EMBL· GenBank· DDBJ
AAL54598.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657295
EMBL· GenBank· DDBJ
ABR93809.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660538
EMBL· GenBank· DDBJ
ACC86307.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660539
EMBL· GenBank· DDBJ
ACC86320.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660540
EMBL· GenBank· DDBJ
ACC86333.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660541
EMBL· GenBank· DDBJ
ACC86346.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660542
EMBL· GenBank· DDBJ
ACC86359.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660543
EMBL· GenBank· DDBJ
ACC86372.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660544
EMBL· GenBank· DDBJ
ACC86385.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660545
EMBL· GenBank· DDBJ
ACC86398.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660546
EMBL· GenBank· DDBJ
ACC86411.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660547
EMBL· GenBank· DDBJ
ACC86424.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660553
EMBL· GenBank· DDBJ
ACC86502.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660554
EMBL· GenBank· DDBJ
ACC86515.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660555
EMBL· GenBank· DDBJ
ACC86528.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660556
EMBL· GenBank· DDBJ
ACC86541.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660557
EMBL· GenBank· DDBJ
ACC86554.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660558
EMBL· GenBank· DDBJ
ACC86567.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660559
EMBL· GenBank· DDBJ
ACC86580.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660560
EMBL· GenBank· DDBJ
ACC86593.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660561
EMBL· GenBank· DDBJ
ACC86606.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660562
EMBL· GenBank· DDBJ
ACC86619.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660563
EMBL· GenBank· DDBJ
ACC86632.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660564
EMBL· GenBank· DDBJ
ACC86645.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660565
EMBL· GenBank· DDBJ
ACC86658.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660566
EMBL· GenBank· DDBJ
ACC86671.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660567
EMBL· GenBank· DDBJ
ACC86684.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660568
EMBL· GenBank· DDBJ
ACC86697.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660569
EMBL· GenBank· DDBJ
ACC86710.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660570
EMBL· GenBank· DDBJ
ACC86723.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660571
EMBL· GenBank· DDBJ
ACC86736.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660572
EMBL· GenBank· DDBJ
ACC86749.1
EMBL· GenBank· DDBJ
Genomic DNA
EU660573
EMBL· GenBank· DDBJ
ACC86762.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ337682
EMBL· GenBank· DDBJ
ACU11438.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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