Q9B1K4 · Q9B1K4_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 6
  • Gene
    ND6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 6
  • EC number

Gene names

    • Name
      ND6
    • Synonyms
      NADH6

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 132
    • MTDNA145
    • XJ8435
    • TCsq0052
    • YK03
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9B1K4
  • Secondary accessions
    • Q85KV0
    • Q85KZ7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-46Helical
Transmembrane53-75Helical
Transmembrane81-104Helical
Transmembrane111-128Helical
Transmembrane148-168Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_501509964016-174NADH-ubiquinone oxidoreductase chain 6

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Sequence similarities

Belongs to the complex I subunit 6 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    174
  • Mass (Da)
    18,595
  • Last updated
    2001-06-01 v1
  • Checksum
    380CC4EEFAFC6019
MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFSSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF346970
EMBL· GenBank· DDBJ
AAK17309.1
EMBL· GenBank· DDBJ
Genomic DNA
AF347013
EMBL· GenBank· DDBJ
AAK17868.1
EMBL· GenBank· DDBJ
Genomic DNA
AF382009
EMBL· GenBank· DDBJ
AAL54759.1
EMBL· GenBank· DDBJ
Genomic DNA
AF465961
EMBL· GenBank· DDBJ
AAN14767.1
EMBL· GenBank· DDBJ
Genomic DNA
AY255174
EMBL· GenBank· DDBJ
AAO67161.1
EMBL· GenBank· DDBJ
Genomic DNA
AY195753
EMBL· GenBank· DDBJ
AAO88395.2
EMBL· GenBank· DDBJ
Genomic DNA
AY195759
EMBL· GenBank· DDBJ
AAO88473.1
EMBL· GenBank· DDBJ
Genomic DNA
AY195772
EMBL· GenBank· DDBJ
AAO88642.2
EMBL· GenBank· DDBJ
Genomic DNA
AY519485
EMBL· GenBank· DDBJ
AAR91230.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112787
EMBL· GenBank· DDBJ
AAZ01110.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ272118
EMBL· GenBank· DDBJ
ABB51396.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ282447
EMBL· GenBank· DDBJ
ABB78882.1
EMBL· GenBank· DDBJ
Genomic DNA
EF079875
EMBL· GenBank· DDBJ
ABK28828.1
EMBL· GenBank· DDBJ
Genomic DNA
EF153779
EMBL· GenBank· DDBJ
ABL60123.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657282
EMBL· GenBank· DDBJ
ABR93645.1
EMBL· GenBank· DDBJ
Genomic DNA
EU007839
EMBL· GenBank· DDBJ
ABS57744.1
EMBL· GenBank· DDBJ
Genomic DNA
EU095527
EMBL· GenBank· DDBJ
ABU46753.1
EMBL· GenBank· DDBJ
Genomic DNA
EU095222
EMBL· GenBank· DDBJ
ABU47455.1
EMBL· GenBank· DDBJ
Genomic DNA
EU482304
EMBL· GenBank· DDBJ
ACA21888.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383597
EMBL· GenBank· DDBJ
ACM74898.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ748711
EMBL· GenBank· DDBJ
ACN37218.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ951438
EMBL· GenBank· DDBJ
ACQ73916.1
EMBL· GenBank· DDBJ
Genomic DNA
GU123047
EMBL· GenBank· DDBJ
ACY56022.1
EMBL· GenBank· DDBJ
Genomic DNA
GU215076
EMBL· GenBank· DDBJ
ADA63662.1
EMBL· GenBank· DDBJ
Genomic DNA
HM107306
EMBL· GenBank· DDBJ
ADG46072.1
EMBL· GenBank· DDBJ
Genomic DNA
HM852809
EMBL· GenBank· DDBJ
ADL30594.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012186
EMBL· GenBank· DDBJ
ADM60370.1
EMBL· GenBank· DDBJ
Genomic DNA
GU392063
EMBL· GenBank· DDBJ
ADN41885.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824852
EMBL· GenBank· DDBJ
AEG62635.1
EMBL· GenBank· DDBJ
Genomic DNA
JF896797
EMBL· GenBank· DDBJ
AEG80066.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701741
EMBL· GenBank· DDBJ
AFE62024.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701820
EMBL· GenBank· DDBJ
AFF61629.1
EMBL· GenBank· DDBJ
Genomic DNA
JX266268
EMBL· GenBank· DDBJ
AFP91172.1
EMBL· GenBank· DDBJ
Genomic DNA
JX413040
EMBL· GenBank· DDBJ
AFQ98825.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911332
EMBL· GenBank· DDBJ
AGO91067.1
EMBL· GenBank· DDBJ
Genomic DNA
KF056247
EMBL· GenBank· DDBJ
AGT52409.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252466
EMBL· GenBank· DDBJ
AGX91446.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540681
EMBL· GenBank· DDBJ
AGZ08156.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451226
EMBL· GenBank· DDBJ
AGZ69582.1
EMBL· GenBank· DDBJ
Genomic DNA
KF148083
EMBL· GenBank· DDBJ
AGZ95937.1
EMBL· GenBank· DDBJ
Genomic DNA
KF672804
EMBL· GenBank· DDBJ
AHA47495.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849915
EMBL· GenBank· DDBJ
AHE78794.1
EMBL· GenBank· DDBJ
Genomic DNA
KF874360
EMBL· GenBank· DDBJ
AHH00423.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ923842
EMBL· GenBank· DDBJ
AIJ18885.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101746
EMBL· GenBank· DDBJ
AIU59408.1
EMBL· GenBank· DDBJ
Genomic DNA
KP017258
EMBL· GenBank· DDBJ
AJD85411.1
EMBL· GenBank· DDBJ
Genomic DNA
KM656461
EMBL· GenBank· DDBJ
AJO61505.1
EMBL· GenBank· DDBJ
Genomic DNA
KR153486
EMBL· GenBank· DDBJ
AKV16285.1
EMBL· GenBank· DDBJ
Genomic DNA
KT891989
EMBL· GenBank· DDBJ
ALM03197.1
EMBL· GenBank· DDBJ
Genomic DNA
KT213745
EMBL· GenBank· DDBJ
ALQ78943.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725861
EMBL· GenBank· DDBJ
ANA92009.1
EMBL· GenBank· DDBJ
Genomic DNA
KX358473
EMBL· GenBank· DDBJ
ANY28041.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456437
EMBL· GenBank· DDBJ
APD52722.1
EMBL· GenBank· DDBJ
Genomic DNA
KX675272
EMBL· GenBank· DDBJ
APZ83243.1
EMBL· GenBank· DDBJ
Genomic DNA
KY409447
EMBL· GenBank· DDBJ
AQU32232.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782186
EMBL· GenBank· DDBJ
ASC43548.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645513
EMBL· GenBank· DDBJ
ASR12457.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680949
EMBL· GenBank· DDBJ
ASZ82437.1
EMBL· GenBank· DDBJ
Genomic DNA
MF588808
EMBL· GenBank· DDBJ
ATI23915.1
EMBL· GenBank· DDBJ
Genomic DNA
MF043426
EMBL· GenBank· DDBJ
ATP01542.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272652
EMBL· GenBank· DDBJ
AVL85907.1
EMBL· GenBank· DDBJ
Genomic DNA
MH359196
EMBL· GenBank· DDBJ
AWV63690.1
EMBL· GenBank· DDBJ
Genomic DNA
MG952858
EMBL· GenBank· DDBJ
AWX65143.1
EMBL· GenBank· DDBJ
Genomic DNA
MH448954
EMBL· GenBank· DDBJ
AYW04125.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981823
EMBL· GenBank· DDBJ
AZJ13680.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008311
EMBL· GenBank· DDBJ
BAE08037.1
EMBL· GenBank· DDBJ
Genomic DNA
MG652750
EMBL· GenBank· DDBJ
QAT98032.1
EMBL· GenBank· DDBJ
Genomic DNA
MH499878
EMBL· GenBank· DDBJ
QBX96212.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059556
EMBL· GenBank· DDBJ
QCB17447.1
EMBL· GenBank· DDBJ
Genomic DNA
MG778654
EMBL· GenBank· DDBJ
QEU53307.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540560
EMBL· GenBank· DDBJ
QGL54506.1
EMBL· GenBank· DDBJ
Genomic DNA
MT418991
EMBL· GenBank· DDBJ
QMP91415.1
EMBL· GenBank· DDBJ
Genomic DNA
MT742580
EMBL· GenBank· DDBJ
QOH99753.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857257
EMBL· GenBank· DDBJ
QTK13907.1
EMBL· GenBank· DDBJ
Genomic DNA
MW467813
EMBL· GenBank· DDBJ
QTK29487.1
EMBL· GenBank· DDBJ
Genomic DNA
MW886111
EMBL· GenBank· DDBJ
QUL59017.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp