Q9B1K4 · Q9B1K4_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 6
- GeneND6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids174 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 6
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9B1K4
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-46 | Helical | ||||
Sequence: PIYGGLVLIVSGVVGCVIILNF | ||||||
Transmembrane | 53-75 | Helical | ||||
Sequence: LMVFLIYLGGMMVVFGYTTAMAI | ||||||
Transmembrane | 81-104 | Helical | ||||
Sequence: AWGSGVEVLVSVLVGLAMEVGLVL | ||||||
Transmembrane | 111-128 | Helical | ||||
Sequence: GVVVVVNFSSVGSWMIYE | ||||||
Transmembrane | 148-168 | Helical | ||||
Sequence: YGRWLVVVTGWTLFVGVYIVI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MMYALFLLSVGLVMG | ||||||
Chain | PRO_5015099640 | 16-174 | NADH-ubiquinone oxidoreductase chain 6 | |||
Sequence: FVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFSSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Sequence similarities
Belongs to the complex I subunit 6 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length174
- Mass (Da)18,595
- Last updated2001-06-01 v1
- Checksum380CC4EEFAFC6019
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF346970 EMBL· GenBank· DDBJ | AAK17309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF347013 EMBL· GenBank· DDBJ | AAK17868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF382009 EMBL· GenBank· DDBJ | AAL54759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF465961 EMBL· GenBank· DDBJ | AAN14767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY255174 EMBL· GenBank· DDBJ | AAO67161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195753 EMBL· GenBank· DDBJ | AAO88395.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195759 EMBL· GenBank· DDBJ | AAO88473.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195772 EMBL· GenBank· DDBJ | AAO88642.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY519485 EMBL· GenBank· DDBJ | AAR91230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112787 EMBL· GenBank· DDBJ | AAZ01110.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ272118 EMBL· GenBank· DDBJ | ABB51396.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282447 EMBL· GenBank· DDBJ | ABB78882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF079875 EMBL· GenBank· DDBJ | ABK28828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF153779 EMBL· GenBank· DDBJ | ABL60123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657282 EMBL· GenBank· DDBJ | ABR93645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU007839 EMBL· GenBank· DDBJ | ABS57744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095527 EMBL· GenBank· DDBJ | ABU46753.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095222 EMBL· GenBank· DDBJ | ABU47455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU482304 EMBL· GenBank· DDBJ | ACA21888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383597 EMBL· GenBank· DDBJ | ACM74898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ748711 EMBL· GenBank· DDBJ | ACN37218.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ951438 EMBL· GenBank· DDBJ | ACQ73916.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU123047 EMBL· GenBank· DDBJ | ACY56022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU215076 EMBL· GenBank· DDBJ | ADA63662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM107306 EMBL· GenBank· DDBJ | ADG46072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852809 EMBL· GenBank· DDBJ | ADL30594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012186 EMBL· GenBank· DDBJ | ADM60370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU392063 EMBL· GenBank· DDBJ | ADN41885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824852 EMBL· GenBank· DDBJ | AEG62635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF896797 EMBL· GenBank· DDBJ | AEG80066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701741 EMBL· GenBank· DDBJ | AFE62024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701820 EMBL· GenBank· DDBJ | AFF61629.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX266268 EMBL· GenBank· DDBJ | AFP91172.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX413040 EMBL· GenBank· DDBJ | AFQ98825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911332 EMBL· GenBank· DDBJ | AGO91067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF056247 EMBL· GenBank· DDBJ | AGT52409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252466 EMBL· GenBank· DDBJ | AGX91446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540681 EMBL· GenBank· DDBJ | AGZ08156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451226 EMBL· GenBank· DDBJ | AGZ69582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148083 EMBL· GenBank· DDBJ | AGZ95937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF672804 EMBL· GenBank· DDBJ | AHA47495.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849915 EMBL· GenBank· DDBJ | AHE78794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF874360 EMBL· GenBank· DDBJ | AHH00423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ923842 EMBL· GenBank· DDBJ | AIJ18885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101746 EMBL· GenBank· DDBJ | AIU59408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP017258 EMBL· GenBank· DDBJ | AJD85411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM656461 EMBL· GenBank· DDBJ | AJO61505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR153486 EMBL· GenBank· DDBJ | AKV16285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT891989 EMBL· GenBank· DDBJ | ALM03197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT213745 EMBL· GenBank· DDBJ | ALQ78943.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725861 EMBL· GenBank· DDBJ | ANA92009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX358473 EMBL· GenBank· DDBJ | ANY28041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456437 EMBL· GenBank· DDBJ | APD52722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675272 EMBL· GenBank· DDBJ | APZ83243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY409447 EMBL· GenBank· DDBJ | AQU32232.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782186 EMBL· GenBank· DDBJ | ASC43548.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645513 EMBL· GenBank· DDBJ | ASR12457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680949 EMBL· GenBank· DDBJ | ASZ82437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF588808 EMBL· GenBank· DDBJ | ATI23915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF043426 EMBL· GenBank· DDBJ | ATP01542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272652 EMBL· GenBank· DDBJ | AVL85907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH359196 EMBL· GenBank· DDBJ | AWV63690.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG952858 EMBL· GenBank· DDBJ | AWX65143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH448954 EMBL· GenBank· DDBJ | AYW04125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981823 EMBL· GenBank· DDBJ | AZJ13680.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008311 EMBL· GenBank· DDBJ | BAE08037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG652750 EMBL· GenBank· DDBJ | QAT98032.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH499878 EMBL· GenBank· DDBJ | QBX96212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059556 EMBL· GenBank· DDBJ | QCB17447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG778654 EMBL· GenBank· DDBJ | QEU53307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540560 EMBL· GenBank· DDBJ | QGL54506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT418991 EMBL· GenBank· DDBJ | QMP91415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT742580 EMBL· GenBank· DDBJ | QOH99753.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857257 EMBL· GenBank· DDBJ | QTK13907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW467813 EMBL· GenBank· DDBJ | QTK29487.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW886111 EMBL· GenBank· DDBJ | QUL59017.1 EMBL· GenBank· DDBJ | Genomic DNA |