Q9B0M9 · Q9B0M9_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 6
- GeneND6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids174 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 6
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9B0M9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-46 | Helical | ||||
Sequence: PIYGGLVLIVSGVVGCVIILNF | ||||||
Transmembrane | 53-75 | Helical | ||||
Sequence: LMVFLIYLGGMMVVFGYTTAMAI | ||||||
Transmembrane | 81-104 | Helical | ||||
Sequence: AWGSGVEVLVSVLVGLAMEVGLVL | ||||||
Transmembrane | 111-128 | Helical | ||||
Sequence: GVVVVVNFNSVGSWMIYE | ||||||
Transmembrane | 148-168 | Helical | ||||
Sequence: YGRWLVVVTGWTLFVGVYVVI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MMYALFLLSVGLVMG | ||||||
Chain | PRO_5015099637 | 16-174 | NADH-ubiquinone oxidoreductase chain 6 | |||
Sequence: FVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYVVIEIARGN |
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Sequence similarities
Belongs to the complex I subunit 6 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length174
- Mass (Da)18,608
- Last updated2001-06-01 v1
- ChecksumFDAFD9F3FAFC600D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF346968 EMBL· GenBank· DDBJ | AAK17283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF346997 EMBL· GenBank· DDBJ | AAK17660.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF381992 EMBL· GenBank· DDBJ | AAL54538.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF465956 EMBL· GenBank· DDBJ | AAN14712.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY255138 EMBL· GenBank· DDBJ | AAO66694.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY195783 EMBL· GenBank· DDBJ | AAO88785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY495309 EMBL· GenBank· DDBJ | AAR95354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112690 EMBL· GenBank· DDBJ | AAY99849.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ272121 EMBL· GenBank· DDBJ | ABB51435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282436 EMBL· GenBank· DDBJ | ABB78739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ341059 EMBL· GenBank· DDBJ | ABC60547.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF153798 EMBL· GenBank· DDBJ | ABL60370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF184612 EMBL· GenBank· DDBJ | ABO39643.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657296 EMBL· GenBank· DDBJ | ABR93826.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU007848 EMBL· GenBank· DDBJ | ABS57861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095204 EMBL· GenBank· DDBJ | ABU47221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU092667 EMBL· GenBank· DDBJ | ABU64107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU200764 EMBL· GenBank· DDBJ | ABW72962.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU273476 EMBL· GenBank· DDBJ | ABX40052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ460522 EMBL· GenBank· DDBJ | ACJ47271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ119013 EMBL· GenBank· DDBJ | ACS48647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ301865 EMBL· GenBank· DDBJ | ACT15670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU123044 EMBL· GenBank· DDBJ | ACY55983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM030510 EMBL· GenBank· DDBJ | ADE33219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM771113 EMBL· GenBank· DDBJ | ADL14839.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM776710 EMBL· GenBank· DDBJ | ADL31842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012175 EMBL· GenBank· DDBJ | ADM60227.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM596648 EMBL· GenBank· DDBJ | ADN10900.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU733733 EMBL· GenBank· DDBJ | ADP22554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824838 EMBL· GenBank· DDBJ | AEG62453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN225465 EMBL· GenBank· DDBJ | AEM23616.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ044792 EMBL· GenBank· DDBJ | AEV46874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ245739 EMBL· GenBank· DDBJ | AEY71059.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701823 EMBL· GenBank· DDBJ | AFF61668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153016 EMBL· GenBank· DDBJ | AFO23392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX266263 EMBL· GenBank· DDBJ | AFP91107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC257337 EMBL· GenBank· DDBJ | AGE01752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC622060 EMBL· GenBank· DDBJ | AGJ95263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC533467 EMBL· GenBank· DDBJ | AGK64320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC993980 EMBL· GenBank· DDBJ | AGO22736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF055291 EMBL· GenBank· DDBJ | AGS17285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540577 EMBL· GenBank· DDBJ | AGZ06804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450887 EMBL· GenBank· DDBJ | AGZ65175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148108 EMBL· GenBank· DDBJ | AGZ96262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185420 EMBL· GenBank· DDBJ | AID07880.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ801483 EMBL· GenBank· DDBJ | AIL92148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101569 EMBL· GenBank· DDBJ | AIU57107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP635237 EMBL· GenBank· DDBJ | AKK32041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819251 EMBL· GenBank· DDBJ | ALM03821.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU521441 EMBL· GenBank· DDBJ | AMK46850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725903 EMBL· GenBank· DDBJ | ANA92554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457286 EMBL· GenBank· DDBJ | APD63758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675285 EMBL· GenBank· DDBJ | APZ83412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595549 EMBL· GenBank· DDBJ | ARD71772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY824986 EMBL· GenBank· DDBJ | ARK17208.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645905 EMBL· GenBank· DDBJ | ASR17553.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF055749 EMBL· GenBank· DDBJ | ASR93673.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF043501 EMBL· GenBank· DDBJ | ATP02517.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF621062 EMBL· GenBank· DDBJ | ATP04810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF381347 EMBL· GenBank· DDBJ | AUR40662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF695872 EMBL· GenBank· DDBJ | AUT77456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981607 EMBL· GenBank· DDBJ | AYV90106.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449251 EMBL· GenBank· DDBJ | AYW07983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981836 EMBL· GenBank· DDBJ | AZJ13849.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK165675 EMBL· GenBank· DDBJ | AZP39874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008534 EMBL· GenBank· DDBJ | BAE10938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008764 EMBL· GenBank· DDBJ | BAE13928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010675 EMBL· GenBank· DDBJ | BAG14586.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009439 EMBL· GenBank· DDBJ | BAG38978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128884 EMBL· GenBank· DDBJ | QBB88391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553736 EMBL· GenBank· DDBJ | QBY37513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK860638 EMBL· GenBank· DDBJ | QEG54295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG778656 EMBL· GenBank· DDBJ | QEU53333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK248307 EMBL· GenBank· DDBJ | QFV14783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG660751 EMBL· GenBank· DDBJ | QKJ84068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419312 EMBL· GenBank· DDBJ | QMP95588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK795838 EMBL· GenBank· DDBJ | QQP22716.1 EMBL· GenBank· DDBJ | Genomic DNA |