Q9ASW3 · IQD21_ARATH
- ProteinProtein IQ-DOMAIN 21
- GeneIQD21
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids471 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).
Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).
Involved in abscisic acid (ABA)-mediated signaling pathways leading to the production of hydrogen peroxide H2O2 and the subsequent [Ca2+] cytoplasmic oscillations-dependent regulation of stomatal closure (PubMed:10963598, PubMed:11429606).
Required for [CO2] modulation of the cytosolic Ca2+ transient rate and for high CO2-induced stomatal closing (PubMed:16651523, PubMed:19302418).
Essential for both cold and ABA induction of XERO2 (PubMed:18088305).
May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).
Involved in abscisic acid (ABA)-mediated signaling pathways leading to the production of hydrogen peroxide H2O2 and the subsequent [Ca2+] cytoplasmic oscillations-dependent regulation of stomatal closure (PubMed:10963598, PubMed:11429606).
Required for [CO2] modulation of the cytosolic Ca2+ transient rate and for high CO2-induced stomatal closing (PubMed:16651523, PubMed:19302418).
Essential for both cold and ABA induction of XERO2 (PubMed:18088305).
May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | calmodulin binding | |
Biological Process | abscisic acid-activated signaling pathway | |
Biological Process | calcium ion homeostasis | |
Biological Process | calcium-mediated signaling | |
Biological Process | cellular response to carbon dioxide | |
Biological Process | regulation of stomatal closure | |
Biological Process | response to abscisic acid | |
Biological Process | response to cold | |
Biological Process | response to hydrogen peroxide |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein IQ-DOMAIN 21
- Short namesAtIQD21
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9ASW3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Insensitivity to abscisic acid (ABA) associated with disrupted activation of Ca2+ channels by hydrogen peroxide H2O2, increased frequencies but reduced transient duration of [Ca2+] cytoplasmic oscillations, and leading to altered ABA- and H2O2-induced stomatal closing (PubMed:10963598, PubMed:11429606).
Abnormal [CO2] modulation of the cytosolic Ca2+ transient rate and strong impairment in high CO2-induced stomatal closing (PubMed:16651523, PubMed:19302418).
Reduced induction of XERO2 in response to cold and ABA (PubMed:18088305).
Abnormal [CO2] modulation of the cytosolic Ca2+ transient rate and strong impairment in high CO2-induced stomatal closing (PubMed:16651523, PubMed:19302418).
Reduced induction of XERO2 in response to cold and ABA (PubMed:18088305).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 49 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000453126 | 1-471 | Protein IQ-DOMAIN 21 | |||
Sequence: MGKKGSGGWFSTVKKKVFKSSPKDSKRENNIGSNNADIWQQQHDTQEVVSFEHFPAESSPEISHDVESTASTPATNVGDRKHAMAVAIATAAAAEAAVAAAQAAAKVVRLAGYNRQTEEDSAAVLIQSHYRGYLARRALRALKGLVRLQALVRGNHVRKQAQMTMKCMQALVRVQGRVRARRLQVAHDRFKKQFEEEEKRSGMEKPNKGFANLKTEREKPKKLHEVNRTSLYQTQGKEKERSEGMMKRERALAYAYTYQRQMQHTNSEEGIGLSSNGPDRNQWAWNWLDHWMSSQPYTGRQTGPGPGPGQYNPPPYPPFPTAAATTTSDDVSEKTVEMDVTTPTSLKGNIIGLIDREYIDLGSYRQGHKQRKSPTHIPSYMAPTASAKAKVRDQGPTVKLQGTSFMPYWNSSTKNGSVNGSGCDSSSSGGAITTGYPGPRSPNPKSDIRRKPVSPSQSPTGFGKRGWRHDH |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Binds to multiple calmodulin (CaM) in the presence of Ca2+ and CaM-like proteins.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, motif, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-35 | Disordered | ||||
Sequence: MGKKGSGGWFSTVKKKVFKSSPKDSKRENNIGSNN | ||||||
Motif | 2-9 | Nuclear localization signal | ||||
Sequence: GKKGSGGW | ||||||
Region | 54-76 | Disordered | ||||
Sequence: FPAESSPEISHDVESTASTPATN | ||||||
Compositional bias | 62-76 | Polar residues | ||||
Sequence: ISHDVESTASTPATN | ||||||
Domain | 119-147 | IQ 1 | ||||
Sequence: EDSAAVLIQSHYRGYLARRALRALKGLVR | ||||||
Region | 137-145 | Calmodulin-binding | ||||
Sequence: RALRALKGL | ||||||
Domain | 148-170 | IQ 2 | ||||
Sequence: LQALVRGNHVRKQAQMTMKCMQA | ||||||
Region | 196-221 | Disordered | ||||
Sequence: EEEKRSGMEKPNKGFANLKTEREKPK | ||||||
Region | 295-316 | Disordered | ||||
Sequence: QPYTGRQTGPGPGPGQYNPPPY | ||||||
Compositional bias | 416-434 | Polar residues | ||||
Sequence: GSVNGSGCDSSSSGGAITT | ||||||
Region | 416-471 | Disordered | ||||
Sequence: GSVNGSGCDSSSSGGAITTGYPGPRSPNPKSDIRRKPVSPSQSPTGFGKRGWRHDH |
Sequence similarities
Belongs to the IQD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length471
- Mass (Da)52,094
- Last updated2001-06-01 v1
- Checksum556415C17392BBCF
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4IWT1 | F4IWT1_ARATH | IQD21 | 472 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 62-76 | Polar residues | ||||
Sequence: ISHDVESTASTPATN | ||||||
Compositional bias | 416-434 | Polar residues | ||||
Sequence: GSVNGSGCDSSSSGGAITT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY484700 EMBL· GenBank· DDBJ | AAR32943.1 EMBL· GenBank· DDBJ | mRNA | ||
AL132956 EMBL· GenBank· DDBJ | CAB66405.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002686 EMBL· GenBank· DDBJ | AEE78516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE78517.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | ANM65033.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF361635 EMBL· GenBank· DDBJ | AAK32803.1 EMBL· GenBank· DDBJ | mRNA | ||
BT000602 EMBL· GenBank· DDBJ | AAN18171.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087861 EMBL· GenBank· DDBJ | AAM65413.1 EMBL· GenBank· DDBJ | mRNA |