Q9ASW3 · IQD21_ARATH

Function

function

May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).
Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).
Involved in abscisic acid (ABA)-mediated signaling pathways leading to the production of hydrogen peroxide H2O2 and the subsequent [Ca2+] cytoplasmic oscillations-dependent regulation of stomatal closure (PubMed:10963598, PubMed:11429606).
Required for [CO2] modulation of the cytosolic Ca2+ transient rate and for high CO2-induced stomatal closing (PubMed:16651523, PubMed:19302418).
Essential for both cold and ABA induction of XERO2 (PubMed:18088305).
May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioncalmodulin binding
Biological Processabscisic acid-activated signaling pathway
Biological Processcalcium ion homeostasis
Biological Processcalcium-mediated signaling
Biological Processcellular response to carbon dioxide
Biological Processregulation of stomatal closure
Biological Processresponse to abscisic acid
Biological Processresponse to cold
Biological Processresponse to hydrogen peroxide

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein IQ-DOMAIN 21
  • Short names
    AtIQD21
  • Alternative names
    • Protein GROWTH CONTROLLED BY ABSCISIC ACID 2
    • Protein GUARD CELL ASSOCIATED 2

Gene names

    • Name
      IQD21
    • Synonyms
      GCA2
    • ORF names
      F2K15.120
    • Ordered locus names
      At3g49260

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9ASW3
  • Secondary accessions
    • Q9M3A6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Insensitivity to abscisic acid (ABA) associated with disrupted activation of Ca2+ channels by hydrogen peroxide H2O2, increased frequencies but reduced transient duration of [Ca2+] cytoplasmic oscillations, and leading to altered ABA- and H2O2-induced stomatal closing (PubMed:10963598, PubMed:11429606).
Abnormal [CO2] modulation of the cytosolic Ca2+ transient rate and strong impairment in high CO2-induced stomatal closing (PubMed:16651523, PubMed:19302418).
Reduced induction of XERO2 in response to cold and ABA (PubMed:18088305).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 49 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004531261-471Protein IQ-DOMAIN 21

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Binds to multiple calmodulin (CaM) in the presence of Ca2+ and CaM-like proteins.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif, compositional bias, domain.

TypeIDPosition(s)Description
Region1-35Disordered
Motif2-9Nuclear localization signal
Region54-76Disordered
Compositional bias62-76Polar residues
Domain119-147IQ 1
Region137-145Calmodulin-binding
Domain148-170IQ 2
Region196-221Disordered
Region295-316Disordered
Compositional bias416-434Polar residues
Region416-471Disordered

Sequence similarities

Belongs to the IQD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    471
  • Mass (Da)
    52,094
  • Last updated
    2001-06-01 v1
  • Checksum
    556415C17392BBCF
MGKKGSGGWFSTVKKKVFKSSPKDSKRENNIGSNNADIWQQQHDTQEVVSFEHFPAESSPEISHDVESTASTPATNVGDRKHAMAVAIATAAAAEAAVAAAQAAAKVVRLAGYNRQTEEDSAAVLIQSHYRGYLARRALRALKGLVRLQALVRGNHVRKQAQMTMKCMQALVRVQGRVRARRLQVAHDRFKKQFEEEEKRSGMEKPNKGFANLKTEREKPKKLHEVNRTSLYQTQGKEKERSEGMMKRERALAYAYTYQRQMQHTNSEEGIGLSSNGPDRNQWAWNWLDHWMSSQPYTGRQTGPGPGPGQYNPPPYPPFPTAAATTTSDDVSEKTVEMDVTTPTSLKGNIIGLIDREYIDLGSYRQGHKQRKSPTHIPSYMAPTASAKAKVRDQGPTVKLQGTSFMPYWNSSTKNGSVNGSGCDSSSSGGAITTGYPGPRSPNPKSDIRRKPVSPSQSPTGFGKRGWRHDH

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4IWT1F4IWT1_ARATHIQD21472

Sequence caution

The sequence CAB66405.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias62-76Polar residues
Compositional bias416-434Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY484700
EMBL· GenBank· DDBJ
AAR32943.1
EMBL· GenBank· DDBJ
mRNA
AL132956
EMBL· GenBank· DDBJ
CAB66405.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE78516.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE78517.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
ANM65033.1
EMBL· GenBank· DDBJ
Genomic DNA
AF361635
EMBL· GenBank· DDBJ
AAK32803.1
EMBL· GenBank· DDBJ
mRNA
BT000602
EMBL· GenBank· DDBJ
AAN18171.1
EMBL· GenBank· DDBJ
mRNA
AY087861
EMBL· GenBank· DDBJ
AAM65413.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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