Q9AJF7 · MSRA_THEVU
- ProteinPeptide methionine sulfoxide reductase MsrA
- GenemsrA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids123 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + RHEA-COMP:12313 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ RHEA-COMP:12315
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 8 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-methionine-(S)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | cellular response to oxidative stress | |
Biological Process | protein modification process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide methionine sulfoxide reductase MsrA
- EC number
- Short namesProtein-methionine-S-oxide reductase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Thermoactinomycetaceae > Thermoactinomyces
Accessions
- Primary accessionQ9AJF7
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000138605 | 1-123 | Peptide methionine sulfoxide reductase MsrA | |||
Sequence: MATFGAGCFWGVEETFRQVPGVIDTAVGYMGGTTENPTYEEVCTDKTGHAEVVQVEYDPEQVSYEELLNVFWDNHNPTTLNRQGPDVGTNIARLFFTTLKSKEIPQKNPKRKWIKAGVGKIRL |
Structure
Sequence
- Sequence statusComplete
- Length123
- Mass (Da)13,811
- Last updated2001-06-01 v1
- Checksum6625A68D2204255B