Q9AGY7 · GMHA_ANETH

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Cell surface structure biogenesis; S-layer biogenesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site51-53substrate
Binding site60Zn2+ (UniProtKB | ChEBI)
Binding site64substrate
Binding site64Zn2+ (UniProtKB | ChEBI)
Binding site93-94substrate
Binding site119-121substrate
Binding site124substrate
Binding site171substrate
Binding site171Zn2+ (UniProtKB | ChEBI)
Binding site179Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological Processcell wall organization
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process
Biological ProcessS-layer organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 12990 / DSM 10155 / LMG 17166
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Aneurinibacillus group > Aneurinibacillus

Accessions

  • Primary accession
    Q9AGY7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001365161-198Phosphoheptose isomerase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-195SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,495
  • Last updated
    2001-06-01 v1
  • Checksum
    165206FC0C8B8B60
MNDYIKSHIQSSINVKEAILADEELLRLIEQVATKAIEVYQNGNKILLAGNGGSAADAQHIAGEFVSRFYFDRPGLPSLALTTDTSILTAIGNDYGYEHLFSRQLQANGMEGDMFIGISTSGNSSNIIKALEMCKEKGIIAVGLTGATGGKMARLCDYCIKVPSKETPRIQESHIVIGHIICALVEEAIFRNKFVSVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF324836
EMBL· GenBank· DDBJ
AAK27851.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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