Q9AGY7 · GMHA_ANETH
- ProteinPhosphoheptose isomerase
- GenegmhA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids198 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous
The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Catalytic activity
- 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Cell surface structure biogenesis; S-layer biogenesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 51-53 | substrate | ||||
Sequence: NGG | ||||||
Binding site | 60 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 64 | substrate | ||||
Sequence: E | ||||||
Binding site | 64 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 93-94 | substrate | ||||
Sequence: ND | ||||||
Binding site | 119-121 | substrate | ||||
Sequence: STS | ||||||
Binding site | 124 | substrate | ||||
Sequence: S | ||||||
Binding site | 171 | substrate | ||||
Sequence: Q | ||||||
Binding site | 171 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 179 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | D-sedoheptulose 7-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | cell wall organization | |
Biological Process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process | |
Biological Process | S-layer organization |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoheptose isomerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Aneurinibacillus group > Aneurinibacillus
Accessions
- Primary accessionQ9AGY7
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000136516 | 1-198 | Phosphoheptose isomerase | |||
Sequence: MNDYIKSHIQSSINVKEAILADEELLRLIEQVATKAIEVYQNGNKILLAGNGGSAADAQHIAGEFVSRFYFDRPGLPSLALTTDTSILTAIGNDYGYEHLFSRQLQANGMEGDMFIGISTSGNSSNIIKALEMCKEKGIIAVGLTGATGGKMARLCDYCIKVPSKETPRIQESHIVIGHIICALVEEAIFRNKFVSVK |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-195 | SIS | ||||
Sequence: AIEVYQNGNKILLAGNGGSAADAQHIAGEFVSRFYFDRPGLPSLALTTDTSILTAIGNDYGYEHLFSRQLQANGMEGDMFIGISTSGNSSNIIKALEMCKEKGIIAVGLTGATGGKMARLCDYCIKVPSKETPRIQESHIVIGHIICALVEEAIFRNKFV |
Sequence similarities
Belongs to the SIS family. GmhA subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length198
- Mass (Da)21,495
- Last updated2001-06-01 v1
- Checksum165206FC0C8B8B60
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF324836 EMBL· GenBank· DDBJ | AAK27851.1 EMBL· GenBank· DDBJ | Genomic DNA |